TABLE 2.   HBV serologic markers in different stages of infection and convalescence (201a)a


Stage of infection HBsAg Anti-HBs Anti-HBc
HBeAg Anti-HBe
Totalb IgM

Late incubation period +  -  -  - + or -  -
Acute hepatitis B +  - + +++ +  -
HBsAg carrier +  - (+ rarely) +  - + or - + or -
Recent (<6 months; resolved infectionc)  - ++ ++ +  - + or -
Distant (>6 months; resolved infectionc)  - ++ ++  -  - + or -
Vaccinated  - ++  -  -  -  -

a +, positive; ++, strongly positive; +++, very strongly positive; + or -, variable reaction; -, negative.
b The total anti-HBc assay detects both IgM and IgG antibody.
c Resolved, the patient no longer has the disease.