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Clinical Microbiology Reviews, Apr 1997, 358-367, Vol 10, No. 2
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Role of dendritic cells in immunopathogenesis of human immunodeficiency virus infection

D Weissman and AS Fauci
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1576, USA. dweissman@nih.gov

The role of dendritic cells (DC) in the pathogenesis of human immunodeficiency virus (HIV) disease has been a subject of considerable interest for several years. Initial studies focused on the infection, dysfunction, and depletion of DC in HIV-infected individuals. More recent studies have begun to identify the functional role of DC in the initiation and propagation of viral replication in T cells in HIV- infected individuals. This review discusses recent data regarding the role of DC in HIV disease with the aim of delineating basic immunopathogenic principles of infection and the development of therapeutic strategies.


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