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Clinical Microbiology Reviews, October 1998, p. 614-627, Vol. 11, No. 4
0893-8512/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Protease Inhibitors as Antiviral Agents

A. K. Patick* and K. E. Potts

Agouron Pharmaceuticals, Inc., San Diego, California 92121

Currently, there are a number of approved antiviral agents for use in the treatment of viral infections. However, many instances exist in which the use of a second antiviral agent would be beneficial because it would allow the option of either an alternative or a combination therapeutic approach. Accordingly, virus-encoded proteases have emerged as new targets for antiviral intervention. Molecular studies have indicated that viral proteases play a critical role in the life cycle of many viruses by effecting the cleavage of high-molecular-weight viral polyprotein precursors to yield functional products or by catalyzing the processing of the structural proteins necessary for assembly and morphogenesis of virus particles. This review summarizes some of the important general features of virus-encoded proteases and highlights new advances and/or specific challenges that are associated with the research and development of viral protease inhibitors. Specifically, the viral proteases encoded by the herpesvirus, retrovirus, hepatitis C virus, and human rhinovirus families are discussed.

* Corresponding author. Mailing address: Department of Virology, Agouron Pharmaceuticals, Inc., 4245 Sorrento Valley Blvd., San Diego, CA 92121. Phone: (619) 622-3117. Fax: (619) 622-5999. E-mail: patick{at}agouron.com.

Clinical Microbiology Reviews, October 1998, p. 614-627, Vol. 11, No. 4
0893-8512/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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Antimicrob. Agents Chemother. Clin. Vaccine Immunol.
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Copyright © 1998 by the American Society for Microbiology. All rights reserved.