Management of Infections Due to Antibiotic-Resistant Streptococcus pneumoniae

This Article

	Full Text
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager
	Reprints and Permissions
	Copyright Information
	Books from ASM Press
	MicrobeWorld

Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Kaplan, S. L.
	Articles by Mason, E. O.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Kaplan, S. L.
	Articles by Mason, E. O., Jr.

Previous Article | Next Article

Clinical Microbiology Reviews, October 1998, p. 628-644, Vol. 11, No. 4
0893-8512/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Management of Infections Due to Antibiotic-Resistant Streptococcus pneumoniae

Sheldon L. Kaplan^* and Edward O. Mason Jr.

Section of Pediatric Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030

Antibiotic-resistant strains of Streptococcus pneumoniae are becoming more prevalent throughout the world; this has resultedin modifications of treatment approaches. Management of bacterialmeningitis has the greatest consensus. Strategies for treatingother systemic infections such as pneumonia, bacteremia, and musculoskeletalinfections are evolving, in part related to the availability ofnew antibiotics which are active in vitro against isolates resistantto penicillin and the extended-spectrum cephalosporins. However,there are currently very limited data related to the clinicalefficacy of these new agents. The studies upon which current recommendationsare based are reviewed. Otitis media represents the single mostcommon infection due to S. pneumoniae. Recommendations for treatmentof acute otitis media due to drug-resistant strains and the rationalefor these recommendations are discussed.

^* Corresponding author. Mailing address: Texas Children's Hospital, MC-3-2371, 6621 Fannin, Houston, TX 77030. Phone: (713)770-4330. Fax: (713) 770-4347. E-mail: skaplan{at}bcm.tmc.edu.

Clinical Microbiology Reviews, October 1998, p. 628-644, Vol. 11, No. 4
0893-8512/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

This article has been cited by other articles:

Hsieh, Y.-C., Chang, K.-Y., Huang, Y.-C., Lin, H.-C., Ho, Y.-H., Huang, L.-M., Hsueh, P.-R. (2008). Clonal Spread of Highly {beta}-Lactam-Resistant Streptococcus pneumoniae Isolates in Taiwan. Antimicrob. Agents Chemother. 52: 2266-2269 [Abstract] [Full Text]
Stucki, A., Gerber, P., Acosta, F., Cottagnoud, M., Cottagnoud, P., Jiang, L., Nguyen, P., Wachtel, D., Wang, G., Phan, L. T. (2008). Effects of EDP-420 on penicillin-resistant and quinolone- and penicillin-resistant pneumococci in the rabbit meningitis model. J Antimicrob Chemother 61: 665-669 [Abstract] [Full Text]
Ressner, R. A., Moore, M. R., Jorgensen, J. H. (2008). Activity of the Diaminopyrimidine AR-709 against Recently Collected Multidrug-Resistant Isolates of Invasive Streptococcus pneumoniae from North America. Antimicrob. Agents Chemother. 52: 1147-1149 [Abstract] [Full Text]
Nieto, C., Cherny, I., Khoo, S. K., de Lacoba, M. G., Chan, W. T., Yeo, C. C., Gazit, E., Espinosa, M. (2007). The yefM-yoeB Toxin-Antitoxin Systems of Escherichia coli and Streptococcus pneumoniae: Functional and Structural Correlation. J. Bacteriol. 189: 1266-1278 [Abstract] [Full Text]
Ribes, S., Taberner, F., Domenech, A., Cabellos, C., Tubau, F., Linares, J., Viladrich, P. F., Gudiol, F. (2005). Evaluation of ceftriaxone, vancomycin and rifampicin alone and combined in an experimental model of meningitis caused by highly cephalosporin-resistant Streptococcus pneumoniae ATCC 51916. J Antimicrob Chemother 56: 979-982 [Abstract] [Full Text]
Fernandez, A., Cabellos, C., Tubau, F., Maiques, J. M., Domenech, A., Ribes, S., Linares, J., Viladrich, P. F., Gudiol, F. (2005). Experimental study of teicoplanin, alone and in combination, in the therapy of cephalosporin-resistant pneumococcal meningitis. J Antimicrob Chemother 55: 78-83 [Abstract] [Full Text]
Cottagnoud, P., Pfister, M., Acosta, F., Cottagnoud, M., Flatz, L., Kuhn, F., Muller, H.-P., Stucki, A. (2004). Daptomycin Is Highly Efficacious against Penicillin-Resistant and Penicillin- and Quinolone-Resistant Pneumococci in Experimental Meningitis. Antimicrob. Agents Chemother. 48: 3928-3933 [Abstract] [Full Text]
Decousser, J.-W., Pina, P., Viguier, F., Picot, F., Courvalin, P., Allouch, P. (2004). Invasive Streptococcus pneumoniae in France: Antimicrobial Resistance, Serotype, and Molecular Epidemiology Findings from a Monthly National Study in 2000 to 2002. Antimicrob. Agents Chemother. 48: 3636-3639 [Abstract] [Full Text]
Schrag, S. J., McGee, L., Whitney, C. G., Beall, B., Craig, A. S., Choate, M. E., Jorgensen, J. H., Facklam, R. R., Klugman, K. P., the Active Bacterial Core Surveillance Team, (2004). Emergence of Streptococcus pneumoniae with Very-High-Level Resistance to Penicillin. Antimicrob. Agents Chemother. 48: 3016-3023 [Abstract] [Full Text]
Buxbaum, A., Forsthuber, S., Graninger, W., Georgopoulos, A., on behalf of The Austrian Bacterial Surveillance N, (2004). Serotype distribution and antimicrobial resistance of Streptococcus pneumoniae in Austria. J Antimicrob Chemother 54: 247-250 [Abstract] [Full Text]
Ibrahim, Y. M., Kerr, A. R., McCluskey, J., Mitchell, T. J. (2004). Role of HtrA in the Virulence and Competence of Streptococcus pneumoniae. Infect. Immun. 72: 3584-3591 [Abstract] [Full Text]
Flatz, L., Cottagnoud, M., Kuhn, F., Entenza, J., Stucki, A., Cottagnoud, P. (2004). Ceftriaxone acts synergistically with levofloxacin in experimental meningitis and reduces levofloxacin-induced resistance in penicillin-resistant pneumococci. J Antimicrob Chemother 53: 305-310 [Abstract] [Full Text]
Hoffman, J. A., Mason, E. O., Schutze, G. E., Tan, T. Q., Barson, W. J., Givner, L. B., Wald, E. R., Bradley, J. S., Yogev, R., Kaplan, S. L. (2003). Streptococcus pneumoniae Infections in the Neonate. Pediatrics 112: 1095-1102 [Abstract] [Full Text]
(2003). Index of Suspicion. Pediatr. Rev. 24: 311-316 [Full Text]
Kuhn, F., Cottagnoud, M., Acosta, F., Flatz, L., Entenza, J., Cottagnoud, P. (2003). Cefotaxime Acts Synergistically with Levofloxacin in Experimental Meningitis Due to Penicillin-Resistant Pneumococci and Prevents Selection of Levofloxacin-Resistant Mutants In Vitro. Antimicrob. Agents Chemother. 47: 2487-2491 [Abstract] [Full Text]
Cottagnoud, P., Pfister, M., Cottagnoud, M., Acosta, F., Tauber, M. G. (2003). Activities of Ertapenem, a New Long-Acting Carbapenem, against Penicillin-Sensitive or -Resistant Pneumococci in Experimental Meningitis. Antimicrob. Agents Chemother. 47: 1943-1947 [Abstract] [Full Text]
Dominguez, J., Blanco, S., Rodrigo, C., Azuara, M., Gali, N., Mainou, A., Esteve, A., Castellvi, A., Prat, C., Matas, L., Ausina, V. (2003). Usefulness of Urinary Antigen Detection by an Immunochromatographic Test for Diagnosis of Pneumococcal Pneumonia in Children. J. Clin. Microbiol. 41: 2161-2163 [Abstract] [Full Text]
Decousser, J.-W., Pina, P., Picot, F., Delalande, C., Pangon, B., Courvalin, P., Allouch, P., the ColBVH study group, (2003). Frequency of isolation and antimicrobial susceptibility of bacterial pathogens isolated from patients with bloodstream infections: a French prospective national survey. J Antimicrob Chemother 51: 1213-1222 [Abstract] [Full Text]
Cottagnoud, P., Cottagnoud, M., Tauber, M. G. (2003). Vancomycin Acts Synergistically with Gentamicin against Penicillin-Resistant Pneumococci by Increasing the Intracellular Penetration of Gentamicin. Antimicrob. Agents Chemother. 47: 144-147 [Abstract] [Full Text]
Cottagnoud, P., Acosta, F., Cottagnoud, M., Tauber, M. G. (2002). Gemifloxacin Is Efficacious against Penicillin-Resistant and Quinolone-Resistant Pneumococci in Experimental Meningitis. Antimicrob. Agents Chemother. 46: 1607-1609 [Abstract] [Full Text]
Cottagnoud, P., Acosta, F., Cottagnoud, M., Tauber, M. G. (2002). Cefepime is efficacious against penicillin- and quinolone-resistant pneumococci in experimental meningitis. J Antimicrob Chemother 49: 327-330 [Abstract] [Full Text]
Sahm, D. F., Thornsberry, C., Mayfield, D. C., Jones, M. E., Karlowsky, J. A. (2002). In Vitro Activities of Broad-Spectrum Cephalosporins against Nonmeningeal Isolates of Streptococcus pneumoniae: MIC Interpretation Using NCCLS M100-S12 Recommendations. J. Clin. Microbiol. 40: 669-674 [Abstract] [Full Text]
Cottagnoud, P., Acosta, F., Cottagnoud, M., Pfister, M., Tauber, M. G. (2002). Efficacies of BMS 284756 against Penicillin-Sensitive, Penicillin-Resistant, and Quinolone-Resistant Pneumococci in Experimental Meningitis. Antimicrob. Agents Chemother. 46: 184-187 [Abstract] [Full Text]
Perz, J. F., Craig, A. S., Jorgensen, D. M., Hall, S., Schaffner, W. (2001). Evaluation of Innovative Surveillance for Drug-resistant Streptococcus pneumoniae. Am J Epidemiol 154: 1000-1005 [Abstract] [Full Text]
Doern, G. V., Heilmann, K. P., Huynh, H. K., Rhomberg, P. R., Coffman, S. L., Brueggemann, A. B. (2001). Antimicrobial Resistance among Clinical Isolates of Streptococcus pneumoniae in the United States during 1999-2000, Including a Comparison of Resistance Rates since 1994-1995. Antimicrob. Agents Chemother. 45: 1721-1729 [Abstract] [Full Text]
Perrig, M., Acosta, F., Cottagnoud, M., Gerber, C. M., Tauber, M. G., Cottagnoud, P. (2001). Efficacy of gatifloxacin alone and in combination with cefepime against penicillin-resistant Streptococcus pneumoniae in a rabbit meningitis model and in vitro. J Antimicrob Chemother 47: 701-704 [Abstract] [Full Text]
McGee, L., Klugman, K. P., Wasas, A., Capper, T., Brink, A., The Antibiotics Surveillance Forum Of South Africa, (2001). Serotype 19F Multiresistant Pneumococcal Clone Harboring Two Erythromycin Resistance Determinants [erm(B) and mef(A)] in South Africa. Antimicrob. Agents Chemother. 45: 1595-1598 [Abstract] [Full Text]
Erlendsdottir, H., Knudsen, J. D., Odenholt, I., Cars, O., Espersen, F., Frimodt-Møller, N., Fuursted, K., Kristinsson, K. G., Gudmundsson, S. (2001). Penicillin Pharmacodynamics in Four Experimental Pneumococcal Infection Models. Antimicrob. Agents Chemother. 45: 1078-1085 [Abstract] [Full Text]
Benbachir, M., Benredjeb, S., Boye, C. S., Dosso, M., Belabbes, H., Kamoun, A., Kaire, O., Elmdaghri, N. (2001). Two-Year Surveillance of Antibiotic Resistance in Streptococcus pneumoniae in Four African Cities. Antimicrob. Agents Chemother. 45: 627-629 [Abstract] [Full Text]
Cottagnoud, P., Gerber, C. M., Acosta, F., Cottagnoud, M., Neftel, K., Tauber, M. G. (2000). Linezolid against penicillin-sensitive and -resistant pneumococci in the rabbit meningitis model. J Antimicrob Chemother 46: 981-985 [Abstract] [Full Text]
Schrag, S. J., Beall, B., Dowell, S. F. (2000). Limiting the Spread of Resistant Pneumococci: Biological and Epidemiologic Evidence for the Effectiveness of Alternative Interventions. Clin. Microbiol. Rev. 13: 588-601 [Abstract] [Full Text]
Gerber, C. M., Tovar, L., Cottagnoud, M., Neftel, K. A., Tauber, M. G., Cottagnoud, P. (2000). Grepafloxacin against penicillin-resistant pneumococci in the rabbit meningitis model. J Antimicrob Chemother 46: 249-253 [Abstract] [Full Text]
Mason, E. O. Jr, Lamberth, L. B., Kershaw, N. L., Prosser, B. L. T., Zoe, A., Ambrose, P. G. (2000). Streptococcus pneumoniae in the USA: in vitro susceptibility and pharmacodynamic analysis. J Antimicrob Chemother 45: 623-631 [Abstract] [Full Text]
Hsueh, P.-R., Liu, Y.-C., Shyr, J.-M., Wu, T.-L., Yan, J.-J., Wu, J.-J., Leu, H.-S., Chuang, Y.-C., Yeu-Jen Lau, , Luh, K.-T. (2000). Multicenter Surveillance of Antimicrobial Resistance of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in Taiwan during the 1998-1999 Respiratory Season. Antimicrob. Agents Chemother. 44: 1342-1345 [Abstract] [Full Text]
Zeckel, M. L., Preston, D. A., Allen, B. S. (2000). In Vitro Activities of LY333328 and Comparative Agents against Nosocomial Gram-Positive Pathogens Collected in a 1997 Global Surveillance Study. Antimicrob. Agents Chemother. 44: 1370-1374 [Abstract] [Full Text]
Gerber, C. M., Cottagnoud, M., Neftel, K., Tauber, M. G., Cottagnoud, P. (2000). Evaluation of cefepime alone and in combination with vancomycin against penicillin-resistant pneumococci in the rabbit meningitis model and in vitro. J Antimicrob Chemother 45: 63-68 [Abstract] [Full Text]
Marchese, A., Tonoli, E., Debbia, E. A., Schito, G. C. (1999). Macrolide resistance mechanisms and expression of phenotypes among Streptococcus pneumoniae circulating in Italy. J Antimicrob Chemother 44: 461-464 [Abstract] [Full Text]
Fitoussi, F., Doit, C., Geslin, P., Bingen, E. (1999). Killing Activities of Trovafloxacin Alone and in Combination with beta -Lactam Agents, Rifampin, or Vancomycin against Streptococcus pneumoniae Isolates with Various Susceptibilities to Extended-Spectrum Cephalosporins at Concentrations Clinically Achievable in Cerebrospinal Fluid. Antimicrob. Agents Chemother. 43: 2372-2375 [Abstract] [Full Text]
Hsueh, P.-R., Teng, L.-J., Lee, L.-N., Yang, P.-C., Ho, S.-W., Luh, K.-T. (1999). Extremely High Incidence of Macrolide and Trimethoprim-Sulfamethoxazole Resistance among Clinical Isolates of Streptococcus pneumoniae in Taiwan. J. Clin. Microbiol. 37: 897-901 [Abstract] [Full Text]

Antimicrob. Agents Chemother.	Clin. Vaccine Immunol.
J. Clin. Microbiol.	ALL ASM JOURNALS