This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gern, J. E.
Right arrow Articles by Busse, W. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gern, J. E.
Right arrow Articles by Busse, W. W.

 Previous Article  |  Next Article 

Clinical Microbiology Reviews, January 1999, p. 9-18, Vol. 12, No. 1
0893-8512/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Association of Rhinovirus Infections with Asthma

James E. Gern1,* and William W. Busse2

Division of Allergy and Immunology, Department of Pediatrics,1 and Department of Medicine,2 University of Wisconsin---Madison, Madison, Wisconsin

Rhinoviruses are the most common cause of the common cold, but they can cause more severe illnesses in people with underlying lung disorders such as asthma, chronic obstructive pulmonary disease, or cystic fibrosis. Epidemiologic studies with sensitive detection methods such as PCR have identified rhinovirus infection as a major source of asthma exacerbations in both children and adults, especially during the spring and fall. Since rhinoviruses cause little tissue destruction, it is presumed that the immune response to the infection may play an important role in the pathogenesis of rhinovirus-induced exacerbations of asthma. This review examines the epidemiologic association between rhinovirus infections and exacerbations of asthma and outlines current information on immune responses to rhinovirus infection and potential connections between antiviral responses and preexisting allergic inflammation. Finally, current and future strategies for treating rhinovirus infections and virus-induced exacerbations of asthma are discussed.

* Corresponding author. Mailing address: H4/438 CSC, University of Wisconsin Hospital, Madison, WI 53792-4108. Phone: (608) 263-6201. Fax: (608) 263-0440. E-mail: gern{at}medicine.wisc.edu.

Clinical Microbiology Reviews, January 1999, p. 9-18, Vol. 12, No. 1
0893-8512/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Wang, J. H., Kwon, H. J., Chung, Y.-S., Lee, B.-J., Jang, Y. J. (2008). Infection Rate and Virus-Induced Cytokine Secretion in Experimental Rhinovirus Infection in Mucosal Organ Culture: Comparison Between Specimens From Patients With Chronic Rhinosinusitis With Nasal Polyps and Those From Normal Subjects. Arch Otolaryngol Head Neck Surg 134: 424-427 [Abstract] [Full Text]  
  • Tliba, O., Amrani, Y. (2008). Airway Smooth Muscle Cell as an Inflammatory Cell: Lessons Learned from Interferon Signaling Pathways. Proc Am Thorac Soc 5: 106-112 [Abstract] [Full Text]  
  • Tomei, A. A., Choe, M. M., Swartz, M. A. (2008). Effects of dynamic compression on lentiviral transduction in an in vitro airway wall model. Am. J. Physiol. Lung Cell. Mol. Physiol. 294: L79-L86 [Abstract] [Full Text]  
  • Wright, P. F., Deatly, A. M., Karron, R. A., Belshe, R. B., Shi, J. R., Gruber, W. C., Zhu, Y., Randolph, V. B. (2007). Comparison of Results of Detection of Rhinovirus by PCR and Viral Culture in Human Nasal Wash Specimens from Subjects with and without Clinical Symptoms of Respiratory Illness. J. Clin. Microbiol. 45: 2126-2129 [Abstract] [Full Text]  
  • Korpi-Steiner, N. L., Bates, M. E., Lee, W.-M., Hall, D. J., Bertics, P. J. (2006). Human rhinovirus induces robust IP-10 release by monocytic cells, which is independent of viral replication but linked to type I interferon receptor ligation and STAT1 activation. J. Leukoc. Biol. 80: 1364-1374 [Abstract] [Full Text]  
  • Jang, Y. J., Kwon, H-J., Lee, B-J. (2006). Effect of clarithromycin on rhinovirus-16 infection in A549 cells. Eur Respir J 27: 12-19 [Abstract] [Full Text]  
  • Fujii, M., Tanaka, H., Abe, S. (2005). Interferon-{gamma} Up-regulates Expression of Cysteinyl Leukotriene Type 2 Receptors on Eosinophils in Asthmatic Patients. Chest 128: 3148-3155 [Abstract] [Full Text]  
  • Kirchberger, S., Majdic, O., Steinberger, P., Bluml, S., Pfistershammer, K., Zlabinger, G., Deszcz, L., Kuechler, E., Knapp, W., Stockl, J. (2005). Human Rhinoviruses Inhibit the Accessory Function of Dendritic Cells by Inducing Sialoadhesin and B7-H1 Expression. J. Immunol. 175: 1145-1152 [Abstract] [Full Text]  
  • Saiman, L., Siegel, J. (2004). Infection Control in Cystic Fibrosis. Clin. Microbiol. Rev. 17: 57-71 [Abstract] [Full Text]  
  • Lee, W.-M., Wang, W. (2003). Human Rhinovirus Type 16: Mutant V1210A Requires Capsid-Binding Drug for Assembly of Pentamers To Form Virions during Morphogenesis. J. Virol. 77: 6235-6244 [Abstract] [Full Text]  
  • Wat, D (2003). Impact of respiratory viral infections on cystic fibrosis. Postgrad. Med. J. 79: 201-203 [Abstract] [Full Text]  
  • Greenberg, S. B. (2003). Respiratory Consequences of Rhinovirus Infection. Arch Intern Med 163: 278-284 [Abstract] [Full Text]  
  • AMRANI, Y., MOORE, P. E., HOFFMAN, R., SHORE, S. A., PANETTIERI, R. A. JR. (2001). Interferon-gamma Modulates Cysteinyl Leukotriene Receptor-1 Expression and Function in Human Airway Myocytes. Am. J. Respir. Crit. Care Med. 164: 2098-2101 [Abstract] [Full Text]  
  • Suzuki, T., Yanai, M., Yamaya, M., Satoh-Nakagawa, T., Sekizawa, K., Ishida, S., Sasaki, H. (2001). Erythromycin and Common Cold in COPD. Chest 120: 730-733 [Abstract] [Full Text]  
  • Steininger, C., Aberle, S. W., Popow-Kraupp, T. (2001). Early Detection of Acute Rhinovirus Infections by a Rapid Reverse Transcription-PCR Assay. J. Clin. Microbiol. 39: 129-133 [Abstract] [Full Text]  
  • Man, Y., Hart, V. J., Ring, C. J. A., Sanjar, S., West, M. R. (2000). Loss of Epithelial Integrity Resulting from E-Cadherin Dysfunction Predisposes Airway Epithelial Cells to Adenoviral Infection. Am. J. Respir. Cell Mol. Bio. 23: 610-617 [Abstract] [Full Text]  
  • Griego, S. D., Weston, C. B., Adams, J. L., Tal-Singer, R., Dillon, S. B. (2000). Role of p38 Mitogen-Activated Protein Kinase in Rhinovirus-Induced Cytokine Production by Bronchial Epithelial Cells. J. Immunol. 165: 5211-5220 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»