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Clinical Microbiology Reviews, January 1999, p. 9-18, Vol. 12, No. 1
0893-8512/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Association of Rhinovirus Infections with Asthma

James E. Gern1,* and William W. Busse2

Division of Allergy and Immunology, Department of Pediatrics,1 and Department of Medicine,2 University of Wisconsin---Madison, Madison, Wisconsin

Rhinoviruses are the most common cause of the common cold, but they can cause more severe illnesses in people with underlying lung disorders such as asthma, chronic obstructive pulmonary disease, or cystic fibrosis. Epidemiologic studies with sensitive detection methods such as PCR have identified rhinovirus infection as a major source of asthma exacerbations in both children and adults, especially during the spring and fall. Since rhinoviruses cause little tissue destruction, it is presumed that the immune response to the infection may play an important role in the pathogenesis of rhinovirus-induced exacerbations of asthma. This review examines the epidemiologic association between rhinovirus infections and exacerbations of asthma and outlines current information on immune responses to rhinovirus infection and potential connections between antiviral responses and preexisting allergic inflammation. Finally, current and future strategies for treating rhinovirus infections and virus-induced exacerbations of asthma are discussed.

* Corresponding author. Mailing address: H4/438 CSC, University of Wisconsin Hospital, Madison, WI 53792-4108. Phone: (608) 263-6201. Fax: (608) 263-0440. E-mail: gern{at}medicine.wisc.edu.

Clinical Microbiology Reviews, January 1999, p. 9-18, Vol. 12, No. 1
0893-8512/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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Antimicrob. Agents Chemother. Clin. Vaccine Immunol.
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Copyright © 1999 by the American Society for Microbiology. All rights reserved.