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Clinical Microbiology Reviews, April 2000, p. 207-222, Vol. 13, No. 2
0893-8512/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Drug Resistance in Human Helminths: Current Situation and Lessons from Livestock

S. Geerts* and B. Gryseels

Institute of Tropical Medicine, B-2000 Antwerp, Belgium

In this review the available reports on drug resistance in human helminths, particularly hookworms and schistosomes, are critically analyzed. The experiences with helminths of livestock are then reviewed, in particular the factors contributing to the development of anthelmintic resistance, the mechanisms and genetics of resistance to various anthelmintic classes, and the methods available for detection. These experiences appear to be worryingly similar and relevant to the potential development of drug resistance in human helminths. Recommendations to reduce its risks are suggested.

* Corresponding author. Mailing address: Institute of Tropical Medicine, Nationalestraat 155, B-2000 Antwerp, Belgium. Phone: 32-3-2476262. Fax: 32-3-2476268. E-mail: sgeerts{at}itg.be.

Clinical Microbiology Reviews, April 2000, p. 207-222, Vol. 13, No. 2
0893-8512/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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