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Clinical Microbiology Reviews, April 2000, p. 223-235, Vol. 13, No. 2
0893-8512/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Clinical Significance of Hepatitis C Virus Genotypes

Nizar N. Zein*

Division of Gastroenterology and Hepatology and Internal Medicine and Department of Pediatric and Adolescent Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota

On the basis of phylogenetic analysis of nucleotide sequences, multiple genotypes and subtypes of hepatitis C virus (HCV) have been identified. Characterization of these genetic groups is likely to facilitate and contribute to the development of an effective vaccine against infection with HCV. Differences among HCV genotypes in geographic distributions have provided investigators with an epidemiologic marker that can be used to trace the source of HCV infection in a given population. HCV genotype 1 may represent a more aggressive strain and one that is less likely to respond to interferon treatment than HCV genotype 2 or 3. However, these observations require confirmation before HCV genotyping can be used in clinical settings.

* Mailing address: Division of Gastroenterology and Hepatology and Internal Medicine, Mayo Clinic, 200 First St. SW, Rochester, MN 55905. E-mail: zein.nizar{at}mayo.edu.

Clinical Microbiology Reviews, April 2000, p. 223-235, Vol. 13, No. 2
0893-8512/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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