Clinical Significance of Hepatitis C Virus Genotypes

doi:10.1128/CMR.13.2.223-235.2000

This Article

	Full Text
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager
	Reprints and Permissions
	Copyright Information
	Books from ASM Press
	MicrobeWorld

Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Zein, N. N.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Zein, N. N.

Previous Article | Next Article

Clinical Microbiology Reviews, April 2000, p. 223-235, Vol. 13, No. 2
0893-8512/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Clinical Significance of Hepatitis C Virus Genotypes

Nizar N. Zein^*

Division of Gastroenterology and Hepatology and Internal Medicine and Department of Pediatric and Adolescent Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota

On the basis of phylogenetic analysis of nucleotide sequences, multiple genotypes and subtypes of hepatitis C virus (HCV)have been identified. Characterization of these genetic groupsis likely to facilitate and contribute to the development of aneffective vaccine against infection with HCV. Differences amongHCV genotypes in geographic distributions have provided investigatorswith an epidemiologic marker that can be used to trace the sourceof HCV infection in a given population. HCV genotype 1 may representa more aggressive strain and one that is less likely to respondto interferon treatment than HCV genotype 2 or 3. However, theseobservations require confirmation before HCV genotyping can beused in clinicalsettings.

^* Mailing address: Division of Gastroenterology and Hepatology and Internal Medicine, Mayo Clinic, 200 First St. SW, Rochester,MN 55905. E-mail: zein.nizar{at}mayo.edu.

Clinical Microbiology Reviews, April 2000, p. 223-235, Vol. 13, No. 2
0893-8512/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

This article has been cited by other articles:

Herlihy, K. J., Graham, J. P., Kumpf, R., Patick, A. K., Duggal, R., Shi, S. T. (2008). Development of Intergenotypic Chimeric Replicons To Determine the Broad-Spectrum Antiviral Activities of Hepatitis C Virus Polymerase Inhibitors. Antimicrob. Agents Chemother. 52: 3523-3531 [Abstract] [Full Text]
Schulze zur Wiesch, J., Lauer, G. M., Timm, J., Kuntzen, T., Neukamm, M., Berical, A., Jones, A. M., Nolan, B. E., Longworth, S. A., Kasprowicz, V., McMahon, C., Wurcel, A., Lohse, A. W., Lewis-Ximenez, L. L., Chung, R. T., Kim, A. Y., Allen, T. M., Walker, B. D. (2007). Immunologic evidence for lack of heterologous protection following resolution of HCV in patients with non genotype 1 infection. Blood 110: 1559-1569 [Abstract] [Full Text]
Ticehurst, J. R., Hamzeh, F. M., Thomas, D. L. (2007). Factors Affecting Serum Concentrations of Hepatitis C Virus (HCV) RNA in HCV Genotype 1-Infected Patients with Chronic Hepatitis. J. Clin. Microbiol. 45: 2426-2433 [Abstract] [Full Text]
Kato, T., Matsumura, T., Heller, T., Saito, S., Sapp, R. K., Murthy, K., Wakita, T., Liang, T. J. (2007). Production of Infectious Hepatitis C Virus of Various Genotypes in Cell Cultures. J. Virol. 81: 4405-4411 [Abstract] [Full Text]
Jimenez-Hernandez, N., Torres-Puente, M., Bracho, M. A., Garcia-Robles, I., Ortega, E., del Olmo, J., Carnicer, F., Gonzalez-Candelas, F., Moya, A. (2007). Epidemic dynamics of two coexisting hepatitis C virus subtypes. J. Gen. Virol. 88: 123-133 [Abstract] [Full Text]
Cantaloube, J.-F., Laperche, S., Gallian, P., Bouchardeau, F., de Lamballerie, X., de Micco, P. (2006). Analysis of the 5' Noncoding Region versus the NS5b Region in Genotyping Hepatitis C Virus Isolates from Blood Donors in France.. J. Clin. Microbiol. 44: 2051-2056 [Abstract] [Full Text]
Verbeeck, J., Maes, P., Lemey, P., Pybus, O. G., Wollants, E., Song, E., Nevens, F., Fevery, J., Delport, W., Van der Merwe, S., Van Ranst, M. (2006). Investigating the Origin and Spread of Hepatitis C Virus Genotype 5a. J. Virol. 80: 4220-4226 [Abstract] [Full Text]
Yi, M., Villanueva, R. A., Thomas, D. L., Wakita, T., Lemon, S. M. (2006). From the Cover: Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells. Proc. Natl. Acad. Sci. USA 103: 2310-2315 [Abstract] [Full Text]
Antonishyn, N. A., Ast, V. M., McDonald, R. R., Chaudhary, R. K., Lin, L., Andonov, A. P., Horsman, G. B. (2005). Rapid Genotyping of Hepatitis C Virus by Primer-Specific Extension Analysis. J. Clin. Microbiol. 43: 5158-5163 [Abstract] [Full Text]
Dineva, M. A., Candotti, D., Fletcher-Brown, F., Allain, J.-P., Lee, H. (2005). Simultaneous Visual Detection of Multiple Viral Amplicons by Dipstick Assay. J. Clin. Microbiol. 43: 4015-4021 [Abstract] [Full Text]
Cook, L., Jerome, K. R. (2005). Mass Spectrometry for Genotyping Hepatitis C Virus: A Promising New Approach. Clin. Chem. 51: 1091-1092 [Full Text]
Ilina, E. N., Malakhova, M. V., Generozov, E. V., Nikolaev, E. N., Govorun, V. M. (2005). Matrix-Assisted Laser Desorption Ionization-Time of Flight (Mass Spectrometry) for Hepatitis C Virus Genotyping. J. Clin. Microbiol. 43: 2810-2815 [Abstract] [Full Text]
Bortolotti, F, Resti, M, Marcellini, M, Giacchino, R, Verucchi, G, Nebbia, G, Zancan, L, Marazzi, M G, Barbera, C, Maccabruni, A, Zuin, G, Maggiore, G, Balli, F, Vajro, P, Lepore, L, Molesini, M, Guido, M, Bartolacci, S, Noventa, F, the Italian Observatory for Hepatitis C in childre, (2005). Hepatitis C virus (HCV) genotypes in 373 Italian children with HCV infection: changing distribution and correlation with clinical features and outcome. Gut 54: 852-857 [Abstract] [Full Text]
Nicot, F., Legrand-Abravanel, F., Sandres-Saune, K., Boulestin, A., Dubois, M., Alric, L., Vinel, J.-P., Pasquier, C., Izopet, J. (2005). Heterogeneity of hepatitis C virus genotype 4 strains circulating in south-western France. J. Gen. Virol. 86: 107-114 [Abstract] [Full Text]
Abou-Setta, A. M. (2004). Transmission risk of hepatitis C virus via semen during assisted reproduction: how real is it?. Hum Reprod 19: 2711-2717 [Abstract] [Full Text]
Margraf, R. L., Erali, M., Liew, M., Wittwer, C. T. (2004). Genotyping Hepatitis C Virus by Heteroduplex Mobility Analysis Using Temperature Gradient Capillary Electrophoresis. J. Clin. Microbiol. 42: 4545-4551 [Abstract] [Full Text]
Margraf, R. L., Page, S., Erali, M., Wittwer, C. T. (2004). Single-Tube Method for Nucleic Acid Extraction, Amplification, Purification, and Sequencing. Clin. Chem. 50: 1755-1761 [Abstract] [Full Text]
Henquell, C., Cartau, C., Abergel, A., Laurichesse, H., Regagnon, C., De Champs, C., Bailly, J.-L., Peigue-Lafeuille, H. (2004). High Prevalence of Hepatitis C Virus Type 5 in Central France Evidenced by a Prospective Study from 1996 to 2002. J. Clin. Microbiol. 42: 3030-3035 [Abstract] [Full Text]
Kalinina, O., Norder, H., Magnius, L. O. (2004). Full-length open reading frame of a recombinant hepatitis C virus strain from St Petersburg: proposed mechanism for its formation. J. Gen. Virol. 85: 1853-1857 [Abstract] [Full Text]
Cormier, E. G., Tsamis, F., Kajumo, F., Durso, R. J., Gardner, J. P., Dragic, T. (2004). CD81 is an entry coreceptor for hepatitis C virus. Proc. Natl. Acad. Sci. USA 101: 7270-7274 [Abstract] [Full Text]
Gismondi, M. I., Staendner, L. H., Grinstein, S., Guzman, C. A., Preciado, M. V. (2004). Hepatitis C Virus Isolates from Argentina Disclose a Novel Genotype 1-Associated Restriction Pattern. J. Clin. Microbiol. 42: 1298-1301 [Abstract] [Full Text]
Martial, J., Morice, Y., Abel, S., Cabie, A., Rat, C., Lombard, F., Edouard, A., Pierre-Louis, S., Garsaud, P., Bera, O., Chout, R., Gordien, E., Deny, P., Cesaire, R. (2004). Hepatitis C Virus (HCV) Genotypes in the Caribbean Island of Martinique: Evidence for a Large Radiation of HCV-2 and for a Recent Introduction from Europe of HCV-4. J. Clin. Microbiol. 42: 784-791 [Abstract] [Full Text]
Candotti, D., Temple, J., Sarkodie, F., Allain, J.-P. (2003). Frequent Recovery and Broad Genotype 2 Diversity Characterize Hepatitis C Virus Infection in Ghana, West Africa. J. Virol. 77: 7914-7923 [Abstract] [Full Text]
Quarleri, J. F., Bussy, M. V., Mathet, V. L., Ruiz, V., Iacono, R., Lu, L., Robertson, B. H., Oubina, J. R. (2003). In Vitro Detection of Dissimilar Amounts of Hepatitis C Virus (HCV) Subtype-Specific RNA Genomes in Mixes Prepared from Sera of Persons Infected with a Single HCV Genotype. J. Clin. Microbiol. 41: 2727-2733 [Abstract] [Full Text]
Gault, E., Soussan, P., Morice, Y., Sanders, L., Berrada, A., Rogers, B., Deny, P. (2003). Evaluation of a New Serotyping Assay for Detection of Anti-Hepatitis C Virus Type-Specific Antibodies in Serum Samples. J. Clin. Microbiol. 41: 2084-2087 [Abstract] [Full Text]
Lam, A. M. I., Keeney, D., Eckert, P. Q., Frick, D. N. (2003). Hepatitis C Virus NS3 ATPases/Helicases from Different Genotypes Exhibit Variations in Enzymatic Properties. J. Virol. 77: 3950-3961 [Abstract] [Full Text]
Bartosch, B., Dubuisson, J., Cosset, F.-L. (2003). Infectious Hepatitis C Virus Pseudo-particles Containing Functional E1-E2 Envelope Protein Complexes. J. Exp. Med. 197: 633-642 [Abstract] [Full Text]
Richter, S. S. (2002). Laboratory Assays for Diagnosis and Management of Hepatitis C Virus Infection. J. Clin. Microbiol. 40: 4407-4412 [Full Text]
Bullock, G. C., Bruns, D. E., Haverstick, D. M. (2002). Hepatitis C Genotype Determination by Melting Curve Analysis with a Single Set of Fluorescence Resonance Energy Transfer Probes. Clin. Chem. 48: 2147-2154 [Abstract] [Full Text]
Chen, Z., Weck, K. E. (2002). Hepatitis C Virus Genotyping: Interrogation of the 5' Untranslated Region Cannot Accurately Distinguish Genotypes 1a and 1b. J. Clin. Microbiol. 40: 3127-3134 [Abstract] [Full Text]
Wang, T. Y., Kuo, H. T., Chen, L. C., Chen, Y. T., Lin, C. N., Lee, M. M. (2002). Use of Polymerase Chain Reaction for Early Detection and Management of Hepatitis C Virus Infection after Needlestick Injury. Annals of Clinical & Laboratory Science 32: 137-141 [Abstract] [Full Text]
Kalinina, O., Norder, H., Mukomolov, S., Magnius, L. O. (2002). A Natural Intergenotypic Recombinant of Hepatitis C Virus Identified in St. Petersburg. J. Virol. 76: 4034-4043 [Abstract] [Full Text]
Krekulova, L., Rehak, V., Wakil, A. E., Harris, E., Riley, L. W. (2001). Nested Restriction Site-Specific PCR To Detect and Type Hepatitis C Virus (HCV): a Rapid Method To Distinguish HCV Subtype 1b from Other Genotypes. J. Clin. Microbiol. 39: 1774-1780 [Abstract] [Full Text]
Morice, Y., Roulot, D., Grando, V., Stirnemann, J., Gault, E., Jeantils, V., Bentata, M., Jarrousse, B., Lortholary, O., Pallier, C., Dény, P. (2001). Phylogenetic analyses confirm the high prevalence of hepatitis C virus (HCV) type 4 in the Seine-Saint-Denis district (France) and indicate seven different HCV-4 subtypes linked to two different epidemiological patterns. J. Gen. Virol. 82: 1001-1012 [Abstract] [Full Text]

Antimicrob. Agents Chemother.	Clin. Vaccine Immunol.
J. Clin. Microbiol.	ALL ASM JOURNALS