This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Falsey, A. R.
Right arrow Articles by Walsh, E. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Falsey, A. R.
Right arrow Articles by Walsh, E. E.

Next Article 

Clinical Microbiology Reviews, July 2000, p. 371-384, Vol. 13, No. 3
0893-8512/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Respiratory Syncytial Virus Infection in Adults

Ann R. Falsey* and Edward E. Walsh

Rochester General Hospital and University of Rochester School of Medicine and Dentistry, Rochester, New York

Respiratory syncytial virus (RSV) is now recognized as a significant problem in certain adult populations. These include the elderly, persons with cardiopulmonary diseases, and immunocompromised hosts. Epidemiological evidence indicates that the impact of RSV in older adults may be similar to that of nonpandemic influenza. In addition, RSV has been found to cause 2 to 5% of adult community-acquired pneumonias. Attack rates in nursing homes are approximately 5 to 10% per year, with significant rates of pneumonia (10 to 20%) and death (2 to 5%). Clinical features may be difficult to distinguish from those of influenza but include nasal congestion, cough, wheezing, and low-grade fever. Bone marrow transplant patients prior to marrow engraftment are at highest risk for pneumonia and death. Diagnosis of RSV infection in adults is difficult because viral culture and antigen detection are insensitive, presumably due to low viral titers in nasal secretions, but early bronchoscopy is valuable in immunosuppressed patients. Treatment of RSV in the elderly is largely supportive, whereas early therapy with ribavirin and intravenous gamma globulin is associated with improved survival in immunocompromised persons. An effective RSV vaccine has not yet been developed, and thus prevention of RSV infection is limited to standard infection control practices such as hand washing and the use of gowns and gloves.

* Corresponding author. Mailing address: Department of Medicine, Rochester General Hospital, 1425 Portland Ave., Rochester, NY 14621. Phone: (716) 922-4339. Fax: (716) 339-5168. E-mail: ann.falsey{at}viahealth.org.

Clinical Microbiology Reviews, July 2000, p. 371-384, Vol. 13, No. 3
0893-8512/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Liao, R. S., Tomalty, L. L., Majury, A., Zoutman, D. E. (2009). Comparison of Viral Isolation and Multiplex Real-Time Reverse Transcription-PCR for Confirmation of Respiratory Syncytial Virus and Influenza Virus Detection by Antigen Immunoassays. J. Clin. Microbiol. 47: 527-532 [Abstract] [Full Text]  
  • Dodd, J., Riffault, S., Kodituwakku, J. S., Hayday, A. C., Openshaw, P. J. M. (2009). Pulmonary V{gamma}4+ {gamma}{delta} T Cells Have Proinflammatory and Antiviral Effects in Viral Lung Disease. J. Immunol. 182: 1174-1181 [Abstract] [Full Text]  
  • Nichols, W. G., Peck Campbell, A. J., Boeckh, M. (2008). Respiratory Viruses Other than Influenza Virus: Impact and Therapeutic Advances. Clin. Microbiol. Rev. 21: 274-290 [Abstract] [Full Text]  
  • Wissinger, E. L., Stevens, W. W., Varga, S. M., Braciale, T. J. (2008). Proliferative Expansion and Acquisition of Effector Activity by Memory CD4+ T Cells in the Lungs following Pulmonary Virus Infection. J. Immunol. 180: 2957-2966 [Abstract] [Full Text]  
  • Chapman, J., Abbott, E., Alber, D. G., Baxter, R. C., Bithell, S. K., Henderson, E. A., Carter, M. C., Chambers, P., Chubb, A., Cockerill, G. S., Collins, P. L., Dowdell, V. C. L., Keegan, S. J., Kelsey, R. D., Lockyer, M. J., Luongo, C., Najarro, P., Pickles, R. J., Simmonds, M., Taylor, D., Tyms, S., Wilson, L. J., Powell, K. L. (2007). RSV604, a Novel Inhibitor of Respiratory Syncytial Virus Replication. Antimicrob. Agents Chemother. 51: 3346-3353 [Abstract] [Full Text]  
  • Zlateva, K. T., Vijgen, L., Dekeersmaeker, N., Naranjo, C., Van Ranst, M. (2007). Subgroup Prevalence and Genotype Circulation Patterns of Human Respiratory Syncytial Virus in Belgium during Ten Successive Epidemic Seasons. J. Clin. Microbiol. 45: 3022-3030 [Abstract] [Full Text]  
  • (2006). Brief Report: Respiratory Syncytial Virus Activity--United States, 2004-2005. JAMA 295: 267-268 [Full Text]  
  • Trento, A., Viegas, M., Galiano, M., Videla, C., Carballal, G., Mistchenko, A. S., Melero, J. A. (2006). Natural History of Human Respiratory Syncytial Virus Inferred from Phylogenetic Analysis of the Attachment (G) Glycoprotein with a 60-Nucleotide Duplication. J. Virol. 80: 975-984 [Abstract] [Full Text]  
  • Fry, A. M., Shay, D. K., Holman, R. C., Curns, A. T., Anderson, L. J. (2005). Trends in Hospitalizations for Pneumonia Among Persons Aged 65 Years or Older in the United States, 1988-2002. JAMA 294: 2712-2719 [Abstract] [Full Text]  
  • Liuzzi, M., Mason, S. W., Cartier, M., Lawetz, C., McCollum, R. S., Dansereau, N., Bolger, G., Lapeyre, N., Gaudette, Y., Lagace, L., Massariol, M.-J., Do, F., Whitehead, P., Lamarre, L., Scouten, E., Bordeleau, J., Landry, S., Rancourt, J., Fazal, G., Simoneau, B. (2005). Inhibitors of Respiratory Syncytial Virus Replication Target Cotranscriptional mRNA Guanylylation by Viral RNA-Dependent RNA Polymerase. J. Virol. 79: 13105-13115 [Abstract] [Full Text]  
  • Openshaw, P. J. M. (2005). Antiviral Immune Responses and Lung Inflammation after Respiratory Syncytial Virus Infection. Proc Am Thorac Soc 2: 121-125 [Abstract] [Full Text]  
  • Tripp, R. A., Oshansky, C., Alvarez, R. (2005). Cytokines and Respiratory Syncytial Virus Infection. Proc Am Thorac Soc 2: 147-149 [Abstract] [Full Text]  
  • Zlateva, K. T., Lemey, P., Moes, E., Vandamme, A.-M., Van Ranst, M. (2005). Genetic Variability and Molecular Evolution of the Human Respiratory Syncytial Virus Subgroup B Attachment G Protein. J. Virol. 79: 9157-9167 [Abstract] [Full Text]  
  • Openshaw, P. J. M., Tregoning, J. S. (2005). Immune Responses and Disease Enhancement during Respiratory Syncytial Virus Infection. Clin. Microbiol. Rev. 18: 541-555 [Abstract] [Full Text]  
  • Agrawal, A., Tripp, R. A., Anderson, L. J., Nie, S. (2005). Real-Time Detection of Virus Particles and Viral Protein Expression with Two-Color Nanoparticle Probes. J. Virol. 79: 8625-8628 [Abstract] [Full Text]  
  • Arnold, R., Konig, W. (2005). Respiratory Syncytial Virus Infection of Human Lung Endothelial Cells Enhances Selectively Intercellular Adhesion Molecule-1 Expression. J. Immunol. 174: 7359-7367 [Abstract] [Full Text]  
  • Cianci, C., Meanwell, N., Krystal, M. (2005). Antiviral activity and molecular mechanism of an orally active respiratory syncytial virus fusion inhibitor. J Antimicrob Chemother 55: 289-292 [Abstract] [Full Text]  
  • Rutigliano, J. A., Graham, B. S. (2004). Prolonged Production of TNF-{alpha} Exacerbates Illness during Respiratory Syncytial Virus Infection. J. Immunol. 173: 3408-3417 [Abstract] [Full Text]  
  • Ohm-Smith, M. J., Nassos, P. S., Haller, B. L. (2004). Evaluation of the Binax NOW, BD Directigen, and BD Directigen EZ Assays for Detection of Respiratory Syncytial Virus. J. Clin. Microbiol. 42: 2996-2999 [Abstract] [Full Text]  
  • Zlateva, K. T., Lemey, P., Vandamme, A.-M., Van Ranst, M. (2004). Molecular Evolution and Circulation Patterns of Human Respiratory Syncytial Virus Subgroup A: Positively Selected Sites in the Attachment G Glycoprotein. J. Virol. 78: 4675-4683 [Abstract] [Full Text]  
  • Rutigliano, J. A., Johnson, T. R., Hollinger, T. N., Fischer, J. E., Aung, S., Graham, B. S. (2004). Treatment with Anti-LFA-1 Delays the CD8+ Cytotoxic-T-Lymphocyte Response and Viral Clearance in Mice with Primary Respiratory Syncytial Virus Infection. J. Virol. 78: 3014-3023 [Abstract] [Full Text]  
  • Cianci, C., Yu, K.-L., Combrink, K., Sin, N., Pearce, B., Wang, A., Civiello, R., Voss, S., Luo, G., Kadow, K., Genovesi, E. V., Venables, B., Gulgeze, H., Trehan, A., James, J., Lamb, L., Medina, I., Roach, J., Yang, Z., Zadjura, L., Colonno, R., Clark, J., Meanwell, N., Krystal, M. (2004). Orally Active Fusion Inhibitor of Respiratory Syncytial Virus. Antimicrob. Agents Chemother. 48: 413-422 [Abstract] [Full Text]  
  • Hall, C. B. (2004). Managing Bronchiolitis and Respiratory Syncytial Virus: Finding the Yellow Brick Road. Arch Pediatr Adolesc Med 158: 111-112 [Full Text]  
  • Brock, S. C., Goldenring, J. R., Crowe, J. E. Jr. (2003). Apical recycling systems regulate directional budding of respiratory syncytial virus from polarized epithelial cells. Proc. Natl. Acad. Sci. USA 100: 15143-15148 [Abstract] [Full Text]  
  • Haynes, L. M., Jones, L. P., Barskey, A., Anderson, L. J., Tripp, R. A. (2003). Enhanced Disease and Pulmonary Eosinophilia Associated with Formalin-Inactivated Respiratory Syncytial Virus Vaccination Are Linked to G Glycoprotein CX3C-CX3CR1 Interaction and Expression of Substance P. J. Virol. 77: 9831-9844 [Abstract] [Full Text]  
  • McCarthy, C. A., Hall, C. B. (2003). Respiratory Syncytial Virus: Concerns and Control. Pediatr. Rev. 24: 301-309 [Full Text]  
  • Landry, M. L., Ferguson, D. (2003). Suboptimal Detection of Influenza Virus in Adults by the Directigen Flu A+B Enzyme Immunoassay and Correlation of Results with the Number of Antigen-Positive Cells Detected by Cytospin Immunofluorescence. J. Clin. Microbiol. 41: 3407-3409 [Abstract] [Full Text]  
  • Tripp, R. A., Dakhama, A., Jones, L. P., Barskey, A., Gelfand, E. W., Anderson, L. J. (2003). The G Glycoprotein of Respiratory Syncytial Virus Depresses Respiratory Rates through the CX3C Motif and Substance P. J. Virol. 77: 6580-6584 [Abstract] [Full Text]  
  • Glezen, W. P., Couch, R. B. (2003). Estimating Deaths Due to Influenza and Respiratory Syncytial Virus. JAMA 289: 2500-2500 [Full Text]  
  • Douglas, J. L., Panis, M. L., Ho, E., Lin, K.-Y., Krawczyk, S. H., Grant, D. M., Cai, R., Swaminathan, S., Cihlar, T. (2003). Inhibition of Respiratory Syncytial Virus Fusion by the Small Molecule VP-14637 via Specific Interactions with F Protein. J. Virol. 77: 5054-5064 [Abstract] [Full Text]  
  • Thompson, W. W., Shay, D. K., Weintraub, E., Brammer, L., Cox, N., Anderson, L. J., Fukuda, K. (2003). Mortality Associated With Influenza and Respiratory Syncytial Virus in the United States. JAMA 289: 179-186 [Abstract] [Full Text]  
  • Morens, D. M. (2003). Influenza-Related Mortality: Considerations for Practice and Public Health. JAMA 289: 227-229 [Full Text]  
  • van Bleek, G. M., Poelen, M. C., van der Most, R., Brugghe, H. F., Timmermans, H. A. M., Boog, C. J., Hoogerhout, P., Otten, H. G., van Els, C. A. C. M. (2002). Identification of Immunodominant Epitopes Derived from the Respiratory Syncytial Virus Fusion Protein That Are Recognized by Human CD4 T Cells. J. Virol. 77: 980-988 [Abstract] [Full Text]  
  • Viuff, B., Tjornehoj, K., Larsen, L. E., Rontved, C. M., Uttenthal, A., Ronsholt, L., Alexandersen, S. (2002). Replication and Clearance of Respiratory Syncytial Virus: Apoptosis Is an Important Pathway of Virus Clearance after Experimental Infection with Bovine Respiratory Syncytial Virus. Am. J. Pathol. 161: 2195-2207 [Abstract] [Full Text]  
  • Curtis, S. J., Ottolini, M. G., Porter, D. D., Prince, G. A. (2002). Age-Dependent Replication of Respiratory Syncytial Virus in the Cotton Rat. Exp. Biol. Med. 227: 799-802 [Abstract] [Full Text]  
  • Jones, A., Qui, J.M., Bataki, E., Elphick, H., Ritson, S., Evans, G.S., Everard, M.L. (2002). Neutrophil survival is prolonged in the airways of healthy infants and infants with RSV bronchiolitis. Eur Respir J 20: 651-657 [Abstract] [Full Text]  
  • Olszewska, W., Zambon, M., Openshaw, P. J M (2002). Development of vaccines against common colds. Br Med Bull 62: 99-111 [Abstract] [Full Text]  
  • Griffin, M. R., Coffey, C. S., Neuzil, K. M., Mitchel, E. F. Jr, Wright, P. F., Edwards, K. M. (2002). Winter Viruses: Influenza- and Respiratory Syncytial Virus-Related Morbidity in Chronic Lung Disease. Arch Intern Med 162: 1229-1236 [Abstract] [Full Text]  
  • Huntley, C. C., Weiss, W. J., Gazumyan, A., Buklan, A., Feld, B., Hu, W., Jones, T. R., Murphy, T., Nikitenko, A. A., O'Hara, B., Prince, G., Quartuccio, S., Raifeld, Y. E., Wyde, P., O'Connell, J. F. (2002). RFI-641, a Potent Respiratory Syncytial Virus Inhibitor. Antimicrob. Agents Chemother. 46: 841-847 [Abstract] [Full Text]  
  • (2002). Respiratory Syncytial Virus Activity--United States, 2000-01 Season. JAMA 287: 834-835 [Full Text]  
  • Aung, S., Rutigliano, J. A., Graham, B. S. (2001). Alternative Mechanisms of Respiratory Syncytial Virus Clearance in Perforin Knockout Mice Lead to Enhanced Disease. J. Virol. 75: 9918-9924 [Abstract] [Full Text]  
  • Dominguez, K. D. (2001). Treatment and Prevention of RSV Bronchiolitis. Journal of Pharmacy Practice 14: 166-180 [Abstract]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»