This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lou, J.
Right arrow Articles by Grau, G. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lou, J.
Right arrow Articles by Grau, G. E.

 Previous Article  |  Next Article 

Clinical Microbiology Reviews, October 2001, p. 810-820, Vol. 14, No. 4
0893-8512/01/$04.00+0   DOI: 10.1128/CMR.14.4.810-820.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Pathogenesis of Cerebral Malaria: Recent Experimental Data and Possible Applications for Humans

Jinning Lou,1 Ralf Lucas,2 and Georges E. Grau3,*

Department of Surgery1 and Medical Intensive Care,2 University of Geneva, CH-1211 Geneva 14, Switzerland, and INSERM EMI 0019, UFR Pharmacie, Université de la Méditerranée, F-13385 Marseilles, France3

Malaria still is a major public health problem, partly because the pathogenesis of its major complication, cerebral malaria, remains incompletely understood. Experimental models represent useful tools to better understand the mechanisms of this syndrome. Here, data generated by several models are reviewed both in vivo and in vitro; we propose that some pathogenic mechanisms, drawn from data obtained from experiments in a mouse model, may be instrumental in humans. In particular, tumor necrosis factor (TNF) receptor 2 is involved in this syndrome, implying that the transmembrane form of TNF may be more important than the soluble form of the cytokine. It has also been shown that in addition to differences in immune responsiveness between genetically resistant and susceptible mice, there are marked differences at the level of the target cell of the lesion, namely, the brain endothelial cell. In murine cerebral malaria, a paradoxical role of platelets has been proposed. Indeed, platelets appear to be pathogenic rather than protective in inflammatory conditions because they can potentiate the deleterious effects of TNF. More recently, it has been shown that interactions among platelets, leukocytes, and endothelial cells have phenotypic and functional consequences for the endothelial cells. A better understanding of these complex interactions leading to vascular injury will help improve the outcome of cerebral malaria.

* Corresponding author. Mailing address: INSERM EMI 0019, UFR de Pharmacie, Université de la Méditerranée, 27 bd. Jean Moulin, F-13385 Marseille cedex 5, France. Phone: 33 4 91 83 56 00. Fax: 33 4 91 83 56 02. E-mail: georges.grau{at}pharmacie.univ-mrs.fr.

Clinical Microbiology Reviews, October 2001, p. 810-820, Vol. 14, No. 4
0893-8512/01/$04.00+0   DOI: 10.1128/CMR.14.4.810-820.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Finney, C. A. M., Lu, Z., LeBourhis, L., Philpott, D. J., Kain, K. C. (2009). Disruption of Nod-like Receptors Alters Inflammatory Response to Infection but Does Not Confer Protection in Experimental Cerebral Malaria. Am J Trop Med Hyg 80: 718-722 [Abstract] [Full Text]  
  • Oakley, M. S., McCutchan, T. F., Anantharaman, V., Ward, J. M., Faucette, L., Erexson, C., Mahajan, B., Zheng, H., Majam, V., Aravind, L., Kumar, S. (2008). Host Biomarkers and Biological Pathways That Are Associated with the Expression of Experimental Cerebral Malaria in Mice. Infect. Immun. 76: 4518-4529 [Abstract] [Full Text]  
  • Randall, L. M., Amante, F. H., McSweeney, K. A., Zhou, Y., Stanley, A. C., Haque, A., Jones, M. K., Hill, G. R., Boyle, G. M., Engwerda, C. R. (2008). Common Strategies To Prevent and Modulate Experimental Cerebral Malaria in Mouse Strains with Different Susceptibilities. Infect. Immun. 76: 3312-3320 [Abstract] [Full Text]  
  • Patel, S. N., Berghout, J., Lovegrove, F. E., Ayi, K., Conroy, A., Serghides, L., Min-oo, G., Gowda, D. C., Sarma, J. V., Rittirsch, D., Ward, P. A., Liles, W. C., Gros, P., Kain, K. C. (2008). C5 deficiency and C5a or C5aR blockade protects against cerebral malaria. JEM 205: 1133-1143 [Abstract] [Full Text]  
  • Penet, M.-F., Abou-Hamdan, M., Coltel, N., Cornille, E., Grau, G. E., de Reggi, M., Gharib, B. (2008). Protection against cerebral malaria by the low-molecular-weight thiol pantethine. Proc. Natl. Acad. Sci. USA 105: 1321-1326 [Abstract] [Full Text]  
  • Lovegrove, F. E., Gharib, S. A., Patel, S. N., Hawkes, C. A., Kain, K. C., Liles, W. C. (2007). Expression Microarray Analysis Implicates Apoptosis and Interferon-Responsive Mechanisms in Susceptibility to Experimental Cerebral Malaria. Am. J. Pathol. 171: 1894-1903 [Abstract] [Full Text]  
  • Penet, M.-F., Kober, F., Confort-Gouny, S., Le Fur, Y., Dalmasso, C., Coltel, N., Liprandi, A., Gulian, J.-M., Grau, G. E., Cozzone, P. J., Viola, A. (2007). Magnetic Resonance Spectroscopy Reveals an Impaired Brain Metabolic Profile in Mice Resistant to Cerebral Malaria Infected with Plasmodium berghei ANKA. J. Biol. Chem. 282: 14505-14514 [Abstract] [Full Text]  
  • Togbe, D., Schofield, L., Grau, G. E., Schnyder, B., Boissay, V., Charron, S., Rose, S., Beutler, B., Quesniaux, V. F.J., Ryffel, B. (2007). Murine Cerebral Malaria Development Is Independent of Toll-Like Receptor Signaling. Am. J. Pathol. 170: 1640-1648 [Abstract] [Full Text]  
  • Patel, S. N., Lu, Z., Ayi, K., Serghides, L., Gowda, D. C., Kain, K. C. (2007). Disruption of CD36 Impairs Cytokine Response to Plasmodium falciparum Glycosylphosphatidylinositol and Confers Susceptibility to Severe and Fatal Malaria In Vivo. J. Immunol. 178: 3954-3961 [Abstract] [Full Text]  
  • Coppi, A., Cabinian, M., Mirelman, D., Sinnis, P. (2006). Antimalarial activity of allicin, a biologically active compound from garlic cloves.. Antimicrob. Agents Chemother. 50: 1731-1737 [Abstract] [Full Text]  
  • Penet, M.-F., Viola, A., Confort-Gouny, S., Le Fur, Y., Duhamel, G., Kober, F., Ibarrola, D., Izquierdo, M., Coltel, N., Gharib, B., Grau, G. E., Cozzone, P. J. (2005). Imaging Experimental Cerebral Malaria In Vivo: Significant Role of Ischemic Brain Edema. J. Neurosci. 25: 7352-7358 [Abstract] [Full Text]  
  • Voza, T., Vigario, A. M., Belnoue, E., Gruner, A. C., Deschemin, J.-C., Kayibanda, M., Delmas, F., Janse, C. J., Franke-Fayard, B., Waters, A. P., Landau, I., Snounou, G., Renia, L. (2005). Species-Specific Inhibition of Cerebral Malaria in Mice Coinfected with Plasmodium spp.. Infect. Immun. 73: 4777-4786 [Abstract] [Full Text]  
  • van der Heyde, H. C., Gramaglia, I., Sun, G., Woods, C. (2005). Platelet depletion by anti-CD41 ({alpha}IIb) mAb injection early but not late in the course of disease protects against Plasmodium berghei pathogenesis by altering the levels of pathogenic cytokines. Blood 105: 1956-1963 [Abstract] [Full Text]  
  • Combes, V., Coltel, N., Alibert, M., van Eck, M., Raymond, C., Juhan-Vague, I., Grau, G. E., Chimini, G. (2005). ABCA1 Gene Deletion Protects against Cerebral Malaria: Potential Pathogenic Role of Microparticles in Neuropathology. Am. J. Pathol. 166: 295-302 [Abstract] [Full Text]  
  • Lotocki, G., Alonso, O. F., Dietrich, W. D., Keane, R. W. (2004). Tumor Necrosis Factor Receptor 1 and Its Signaling Intermediates Are Recruited to Lipid Rafts in the Traumatized Brain. J. Neurosci. 24: 11010-11016 [Abstract] [Full Text]  
  • Collette, A., Bagot, S., Ferrandiz, M. E., Cazenave, P.-A., Six, A., Pied, S. (2004). A Profound Alteration of Blood TCRB Repertoire Allows Prediction of Cerebral Malaria. J. Immunol. 173: 4568-4575 [Abstract] [Full Text]  
  • Marchetti, L., Klein, M., Schlett, K., Pfizenmaier, K., Eisel, U. L. M. (2004). Tumor Necrosis Factor (TNF)-mediated Neuroprotection against Glutamate-induced Excitotoxicity Is Enhanced by N-Methyl-D-aspartate Receptor Activation: ESSENTIAL ROLE OF A TNF RECEPTOR 2-MEDIATED PHOSPHATIDYLINOSITOL 3-KINASE-DEPENDENT NF-{kappa}B PATHWAY. J. Biol. Chem. 279: 32869-32881 [Abstract] [Full Text]  
  • Combes, V., Taylor, T. E., Juhan-Vague, I., Mege, J.-L., Mwenechanya, J., Tembo, M., Grau, G. E., Molyneux, M. E. (2004). Circulating Endothelial Microparticles in Malawian Children With Severe Falciparum Malaria Complicated With Coma. JAMA 291: 2542-2544 [Full Text]  
  • RAE, C., MCQUILLAN, J. A., PAREKH, S. B., BUBB, W. A., WEISER, S., BALCAR, V. J., HANSEN, A. M., BALL, H. J., HUNT, N. H. (2004). Brain gene expression, metabolism, and bioenergetics: interrelationships in murine models of cerebral and noncerebral malaria. FASEB J. 18: 499-510 [Abstract] [Full Text]  
  • Omer, F. M., de Souza, J. B., Riley, E. M. (2003). Differential Induction of TGF-{beta} Regulates Proinflammatory Cytokine Production and Determines the Outcome of Lethal and Nonlethal Plasmodium yoelii Infections. J. Immunol. 171: 5430-5436 [Abstract] [Full Text]  
  • Sun, G., Chang, W.-L., Li, J., Berney, S. M., Kimpel, D., van der Heyde, H. C. (2003). Inhibition of Platelet Adherence to Brain Microvasculature Protects against Severe Plasmodium berghei Malaria. Infect. Immun. 71: 6553-6561 [Abstract] [Full Text]  
  • Belnoue, E., Costa, F. T. M., Vigario, A. M., Voza, T., Gonnet, F., Landau, I., van Rooijen, N., Mack, M., Kuziel, W. A., Renia, L. (2003). Chemokine Receptor CCR2 Is Not Essential for the Development of Experimental Cerebral Malaria. Infect. Immun. 71: 3648-3651 [Abstract] [Full Text]  
  • Belnoue, E., Kayibanda, M., Deschemin, J.-C., Viguier, M., Mack, M., Kuziel, W. A., Renia, L. (2003). CCR5 deficiency decreases susceptibility to experimental cerebral malaria. Blood 101: 4253-4259 [Abstract] [Full Text]  
  • Chang, W.-L., Li, J., Sun, G., Chen, H.-L., Specian, R. D., Berney, S. M., Granger, D. N., van der Heyde, H. C. (2003). P-Selectin Contributes to Severe Experimental Malaria but Is Not Required for Leukocyte Adhesion to Brain Microvasculature. Infect. Immun. 71: 1911-1918 [Abstract] [Full Text]  
  • Nitcheu, J., Bonduelle, O., Combadiere, C., Tefit, M., Seilhean, D., Mazier, D., Combadiere, B. (2003). Perforin-Dependent Brain-Infiltrating Cytotoxic CD8+ T Lymphocytes Mediate Experimental Cerebral Malaria Pathogenesis. J. Immunol. 170: 2221-2228 [Abstract] [Full Text]  
  • Belnoue, E., Kayibanda, M., Vigario, A. M., Deschemin, J.-C., Rooijen, N. v., Viguier, M., Snounou, G., Renia, L. (2002). On the Pathogenic Role of Brain-Sequestered {alpha}{beta} CD8+ T Cells in Experimental Cerebral Malaria. J. Immunol. 169: 6369-6375 [Abstract] [Full Text]  
  • Angulo, I., Fresno, M. (2002). Cytokines in the Pathogenesis of and Protection against Malaria. CVI 9: 1145-1152 [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»