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Clinical Microbiology Reviews, January 2002, p. 79-94, Vol. 15, No. 1
0893-8512/02/$04.00+0     DOI: 10.1128/CMR.15.1.79-94.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Clinical Aspects and Pathophysiology of Inflammatory Bowel Disease

Barbara A. Hendrickson,1* Ranjana Gokhale,2 and Judy H. Cho3

Section of Infectious Diseases,1 Gastroenterology,2 Department of Pediatrics and the The Martin Boyer Laboratories and Section of Gastroenterology, Department of Medicine, University of Chicago, Chicago, Illinois 606373

The chronic inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, are recognized as important causes of gastrointestinal disease in children and adults. In this review we delineate the clinical manifestations and diagnostic features of IBD. In addition, we summarize important recent advances in our understanding of the immune mediators of intestinal inflammation. This information has led to new therapeutic approaches in IBD. Further, we discuss the considerable data that point to the significance of genetic factors in the development of IBD and the genetic loci which have been implicated through genomewide searches. The commensal bacterial flora also appears to be a critical element, particularly in regards to Crohn's disease, although the precise role of the bacteria in the disease manifestations remains unclear. Current investigations promise to yield fresh insights in these areas.

* Corresponding author. Mailing address: Section of Pediatric Infectious Diseases, University of Chicago, S. Maryland Ave. MC6054, Chicago, IL 60637. Phone: (773) 702-5445. Fax: (773) 702-1196. E-mail: bhendric{at}peds.bsd.uchicago.edu.

Clinical Microbiology Reviews, January 2002, p. 79-94, Vol. 15, No. 1
0893-8512/02/$04.00+0     DOI: 10.1128/CMR.15.1.79-94.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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