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Clinical Microbiology Reviews, October 2002, p. 716-746, Vol. 15, No. 4
0893-8512/02/$04.00+0     DOI: 10.1128/CMR.15.4.716-746.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Clinical and Taxonomic Status of Pathogenic Nonpigmented or Late-Pigmenting Rapidly Growing Mycobacteria

Barbara A. Brown-Elliott* and Richard J. Wallace Jr.

University of Texas Health Center, Department of Microbiology, Tyler, Texas

The history, taxonomy, geographic distribution, clinical disease, and therapy of the pathogenic nonpigmented or late-pigmenting rapidly growing mycobacteria (RGM) are reviewed. Community-acquired disease and health care-associated disease are highlighted for each species. The latter grouping includes health care-associated outbreaks and pseudo-outbreaks as well as sporadic disease cases. Treatment recommendations for each species and type of disease are also described. Special emphasis is on the Mycobacterium fortuitum group, including M. fortuitum, M. peregrinum, and the unnamed third biovariant complex with its recent taxonomic changes and newly recognized species (including M. septicum, M. mageritense, and proposed species M. houstonense and M. bonickei). The clinical and taxonomic status of M. chelonae, M. abscessus, and M. mucogenicum is also detailed, along with that of the closely related new species, M. immunogenum. Additionally, newly recognized species, M. wolinskyi and M. goodii, as well as M. smegmatis sensu stricto, are included in a discussion of the M. smegmatis group. Laboratory diagnosis of RGM using phenotypic methods such as biochemical testing and high-performance liquid chromatography and molecular methods of diagnosis are also discussed. The latter includes PCR-restriction fragment length polymorphism analysis, hybridization, ribotyping, and sequence analysis. Susceptibility testing and antibiotic susceptibility patterns of the RGM are also annotated, along with the current recommendations from the National Committee for Clinical Laboratory Standards (NCCLS) for mycobacterial susceptibility testing.

* Corresponding author. Mailing address: MT(ASCP)SM, Department of Microbiology, The University of Texas Health Center, 11937 US Hwy 271, Tyler, TX 75708. Phone: (903) 877-7685. Fax: (903) 877-7652. E-mail: barbara.elliott{at}uthct.edu.

Clinical Microbiology Reviews, October 2002, p. 716-746, Vol. 15, No. 4
0893-8512/02/$04.00+0     DOI: 10.1128/CMR.15.4.716-746.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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  • Short, W. R., Emery, C., Bhandary, M., O'Donnell, J. A. (2005). Misidentification of Mycobacterium peregrinum, the Causal Organism of a Case of Bacteremia and Automatic Implantable Cardioverter Defibrillator-Associated Infection, Due to Its Unusual Acid-Fast Staining Characteristics. J. Clin. Microbiol. 43: 2015-2017 [Abstract] [Full Text]  
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  • Menendez, M. d. C., Rebollo, M. J., Nunez, M. d. C., Cox, R. A., Garcia, M. J. (2005). Analysis of the Precursor rRNA Fractions of Rapidly Growing Mycobacteria: Quantification by Methods That Include the Use of a Promoter (rrnA P1) as a Novel Standard. J. Bacteriol. 187: 534-543 [Abstract] [Full Text]  
  • Adekambi, T., Reynaud-Gaubert, M., Greub, G., Gevaudan, M.-J., La Scola, B., Raoult, D., Drancourt, M. (2004). Amoebal Coculture of "Mycobacterium massiliense" sp. nov. from the Sputum of a Patient with Hemoptoic Pneumonia. J. Clin. Microbiol. 42: 5493-5501 [Abstract] [Full Text]  
  • Adekambi, T., Drancourt, M. (2004). Dissection of phylogenetic relationships among 19 rapidly growing Mycobacterium species by 16S rRNA, hsp65, sodA, recA and rpoB gene sequencing. Int. J. Syst. Evol. Microbiol. 54: 2095-2105 [Abstract] [Full Text]  
  • Stephan, J., Mailaender, C., Etienne, G., Daffe, M., Niederweis, M. (2004). Multidrug Resistance of a Porin Deletion Mutant of Mycobacterium smegmatis. Antimicrob. Agents Chemother. 48: 4163-4170 [Abstract] [Full Text]  
  • Jimenez, M. S., Campos-Herrero, M. I., Garcia, D., Luquin, M., Herrera, L., Garcia, M. J. (2004). Mycobacterium canariasense sp. nov.. Int. J. Syst. Evol. Microbiol. 54: 1729-1734 [Abstract] [Full Text]  
  • Sedlacek, L., Rifai, M., Feldmann, K., Bange, F. C. (2004). LightCycler-Based Differentiation of Mycobacterium abscessus and Mycobacterium chelonae. J. Clin. Microbiol. 42: 3284-3287 [Abstract] [Full Text]  
  • Hong, T., Butler, W. R., Hollis, F., Floyd, M. M., Toney, S. R., Tang, Y.-W., Steele, C., Leggiadro, R. J. (2003). Characterization of a Novel Rapidly Growing Mycobacterium Species Associated with Sepsis. J. Clin. Microbiol. 41: 5650-5653 [Abstract] [Full Text]  
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  • Han, D., Lee, K. S., Koh, W.-J., Yi, C. A, Kim, T. S., Kwon, O J. (2003). Radiographic and CT Findings of Nontuberculous Mycobacterial Pulmonary Infection Caused by Mycobacterium abscessus. Am. J. Roentgenol. 181: 513-517 [Abstract] [Full Text]  
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