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Clinical Microbiology Reviews, January 2003, p. 114-128, Vol. 16, No. 1
0893-8512/03/$08.00+0     DOI: 10.1128/CMR.16.1.114-128.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Herpes Simplex Virus Resistance to Acyclovir and Penciclovir after Two Decades of Antiviral Therapy

Teresa H. Bacon,1* Myron J. Levin,2 Jeffry J. Leary,3 Robert T. Sarisky,3 and David Sutton3

GlaxoSmithKline Consumer Healthcare, Weybridge, Surrey KT15 0DE, United Kingdom,1 Pediatric Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262,2 Antimicrobial and Host Defense Center of Excellence for Drug Discovery, GlaxoSmithKline Pharmaceuticals, Collegeville, Pennsylvania 194263

Acyclovir, penciclovir, and their prodrugs have been widely used during the past two decades for the treatment of herpesvirus infections. In spite of the distribution of over 2.3 x 106 kg of these nucleoside analogues, the prevalence of acyclovir resistance in herpes simplex virus isolates from immunocompetent hosts has remained stable at approximately 0.3%. In immuncompromised patients, in whom the risk for developing resistance is much greater, the prevalence of resistant virus has also remained stable but at a higher level, typically 4 to 7%. These observations are examined in the light of characteristics of the virus, the drugs, and host factors.

* Corresponding author. Mailing address: GlaxoSmithKline Consumer Healthcare, St George's Ave., Weybridge, Surrey KT15 0DE, United Kingdom. Phone: 44 1932 822185. Fax: 44 1932 822139. E-mail: teresa.h.bacon{at}gsk.com.

Clinical Microbiology Reviews, January 2003, p. 114-128, Vol. 16, No. 1
0893-8512/03/$08.00+0     DOI: 10.1128/CMR.16.1.114-128.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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