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Clinical Microbiology Reviews, July 2003, p. 430-450, Vol. 16, No. 3
0893-8512/03/$08.00+0     DOI: 10.1128/CMR.16.3.430-450.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Versatility of Aminoglycosides and Prospects for Their Future

Sergei B. Vakulenko and Shahriar Mobashery^*

Departments of Chemistry, Pharmacology, and Biochemistry and Molecular Biology, Wayne State University, Detroit, Michigan 48202

Aminoglycoside antibiotics have had a major impact on our ability to treat bacterial infections for the past half century. Whereas the interest in these versatile antibiotics continues to be high, their clinical utility has been compromised by widespread instances of resistance. The multitude of mechanisms of resistance is disconcerting but also illuminates how nature can manifest resistance when bacteria are confronted by antibiotics. This article reviews the most recent knowledge about the mechanisms of aminoglycoside action and the mechanisms of resistance to these antibiotics.

Present address: Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556.

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