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Clinical Microbiology Reviews, October 2003, p. 658-672, Vol. 16, No. 4
0893-8512/03/$08.00+0     DOI: 10.1128/CMR.16.4.658-672.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Potential Uses of Probiotics in Clinical Practice

Gregor Reid,1,2,3* Jana Jass,1,2 M. Tom Sebulsky,2 and John K. McCormick1,2

Canadian Research and Development Centre for Probiotics, The Lawson Health Research Institute, London, Ontario N6A 4V2,1 Departments of Microbiology and Immunology,2 Surgery, University of Western Ontario, London, Ontario N6A 5C1, Canada3

Probiotics are defined as live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. There is now mounting evidence that selected probiotic strains can provide health benefits to their human hosts. Numerous clinical trials show that certain strains can improve the outcome of intestinal infections by reducing the duration of diarrhea. Further investigations have shown benefits in reducing the recurrence of urogenital infections in women, while promising studies in cancer and allergies require research into the mechanisms of activity for particular strains and better-designed trials. At present, only a small percentage of physicians either know of probiotics or understand their potential applicability to patient care. Thus, probiotics are not yet part of the clinical arsenal for prevention and treatment of disease or maintenance of health. The establishment of accepted standards and guidelines, proposed by the Food and Agriculture Organization of the United Nations and the World Health Organization, represents a key step in ensuring that reliable products with suitable, informative health claims become available. Based upon the evidence to date, future advances with single- and multiple-strain therapies are on the horizon for the management of a number of debilitating and even fatal conditions.

* Corresponding author. Mailing address: Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada. Phone: (519) 646-6100, x65256. Fax: (519) 646-6031. E-mail: gregor{at}uwo.ca.

Clinical Microbiology Reviews, October 2003, p. 658-672, Vol. 16, No. 4
0893-8512/03/$08.00+0     DOI: 10.1128/CMR.16.4.658-672.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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