This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Masuoka, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Masuoka, J.

 Previous Article  |  Next Article 

Clinical Microbiology Reviews, April 2004, p. 281-310, Vol. 17, No. 2
0893-8512/04/$08.00+0     DOI: 10.1128/CMR.17.2.281-310.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Surface Glycans of Candida albicans and Other Pathogenic Fungi: Physiological Roles, Clinical Uses, and Experimental Challenges

James Masuoka*

Department of Pathology, University of Virginia, Charlottesville, Virginia 22908-0904

Although fungi have always been with us as commensals and pathogens, fungal infections have been increasing in frequency over the past few decades. There is a growing body of literature describing the involvement of carbohydrate groups in various aspects of fungal disease. Carbohydrates comprising the cell wall or capsule, or as a component of glycoproteins, are the fungal cell surface entities most likely to be exposed to the surrounding environment. Thus, the fungus-host interaction is likely to involve carbohydrates before DNA, RNA, or even protein. The interaction between fungal and host cells is also complex, and early studies using whole cells or crude cell fractions often produced seemingly conflicting results. What was needed, and what has been developing, is the ability to identify specific glycan structures and determine how they interact with immune system components. Carbohydrate analysis is complicated by the complexity of glycan structures and by the challenges of separating and detecting carbohydrates experimentally. Advances in carbohydrate chemistry have enabled us to move from the foundation of composition analysis to more rapid characterization of specific structures. This, in turn, will lead to a greater understanding of how fungi coexist with their hosts as commensals or exist in conflict as pathogens.

* Mailing address: James Masuoka, Department of Pathology, University of Virginia Health System, P.O. Box 800904, Charlottesville, VA 22908-0904. Phone: (434) 243-2744. Fax: (434) 924-2151. E-mail: jm2n{at}virginia.edu.

Clinical Microbiology Reviews, April 2004, p. 281-310, Vol. 17, No. 2
0893-8512/04/$08.00+0     DOI: 10.1128/CMR.17.2.281-310.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Wanchoo, A., Lewis, M. W., Keyhani, N. O. (2009). Lectin mapping reveals stage-specific display of surface carbohydrates in in vitro and haemolymph-derived cells of the entomopathogenic fungus Beauveria bassiana. Microbiology 155: 3121-3133 [Abstract] [Full Text]  
  • Freedman, M., Laks, J, Dotan, N, Altstock, R., Dukler, A, Sindic, C. (2009). Anti-{alpha}-glucose-based glycan IgM antibodies predict relapse activity in multiple sclerosis after the first neurological event. Mult Scler 15: 422-430 [Abstract]  
  • Cambi, A., Netea, M. G., Mora-Montes, H. M., Gow, N. A. R., Hato, S. V., Lowman, D. W., Kullberg, B.-J., Torensma, R., Williams, D. L., Figdor, C. G. (2008). Dendritic Cell Interaction with Candida albicans Critically Depends on N-Linked Mannan. J. Biol. Chem. 283: 20590-20599 [Abstract] [Full Text]  
  • Norice, C. T., Smith, F. J. Jr., Solis, N., Filler, S. G., Mitchell, A. P. (2007). Requirement for Candida albicans Sun41 in Biofilm Formation and Virulence. Eukaryot Cell 6: 2046-2055 [Abstract] [Full Text]  
  • Hazen, K. C, Singleton, D. R, Masuoka, J. (2007). Influence of outer region mannosylphosphorylation on N-glycan formation by Candida albicans: Normal acid-stable N-glycan formation requires acid-labile mannosylphosphate addition. Glycobiology 17: 1052-1060 [Abstract] [Full Text]  
  • Nett, J., Lincoln, L., Marchillo, K., Massey, R., Holoyda, K., Hoff, B., VanHandel, M., Andes, D. (2007). Putative Role of {beta}-1,3 Glucans in Candida albicans Biofilm Resistance. Antimicrob. Agents Chemother. 51: 510-520 [Abstract] [Full Text]  
  • Umeyama, T., Kaneko, A., Watanabe, H., Hirai, A., Uehara, Y., Niimi, M., Azuma, M. (2006). Deletion of the CaBIG1 Gene Reduces {beta}-1,6-Glucan Synthesis, Filamentation, Adhesion, and Virulence in Candida albicans. Infect. Immun. 74: 2373-2381 [Abstract] [Full Text]  
  • Torosantucci, A., Bromuro, C., Chiani, P., De Bernardis, F., Berti, F., Galli, C., Norelli, F., Bellucci, C., Polonelli, L., Costantino, P., Rappuoli, R., Cassone, A. (2005). A novel glyco-conjugate vaccine against fungal pathogens. JEM 202: 597-606 [Abstract] [Full Text]  
  • Granger, B. L., Flenniken, M. L., Davis, D. A., Mitchell, A. P., Cutler, J. E. (2005). Yeast wall protein 1 of Candida albicans. Microbiology 151: 1631-1644 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»