This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lindahl, G.
Right arrow Articles by Areschoug, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lindahl, G.
Right arrow Articles by Areschoug, T.

 Previous Article  |  Next Article 

Clinical Microbiology Reviews, January 2005, p. 102-127, Vol. 18, No. 1
0893-8512/05/$08.00+0     doi:10.1128/CMR.18.1.102-127.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Surface Proteins of Streptococcus agalactiae and Related Proteins in Other Bacterial Pathogens

Gunnar Lindahl,* Margaretha Stålhammar-Carlemalm, and Thomas Areschoug

Department of Medical Microbiology, Dermatology and Infection, Lund University, Sölvegatan 23, Lund, Sweden

Streptococcus agalactiae (group B Streptococcus) is the major cause of invasive bacterial disease, including meningitis, in the neonatal period. Although prophylactic measures have contributed to a substantial reduction in the number of infections, development of a vaccine remains an important goal. While much work in this field has focused on the S. agalactiae polysaccharide capsule, which is an important virulence factor that elicits protective immunity, surface proteins have received increasing attention as potential virulence factors and vaccine components. Here, we summarize current knowledge about S. agalactiae surface proteins, with emphasis on proteins that have been characterized immunochemically and/or elicit protective immunity in animal models. These surface proteins have been implicated in interactions with human epithelial cells, binding to extracellular matrix components, and/or evasion of host immunity. Of note, several S. agalactiae surface proteins are related to surface proteins identified in other bacterial pathogens, emphasizing the general interest of the S. agalactiae proteins. Because some S. agalactiae surface proteins elicit protective immunity, they hold promise as components in a vaccine based only on proteins or as carriers in polysaccharide conjugate vaccines.

* Corresponding author. Mailing address: Department of Medical Microbiology, Dermatology and Infection, Lund University, Sölvegatan 23, SE-22362 Lund, Sweden. Phone: 46 (46) 173244. Fax: 46 (46) 189117. E-mail: gunnar.lindahl{at}mmb.lu.se.

Clinical Microbiology Reviews, January 2005, p. 102-127, Vol. 18, No. 1
0893-8512/05/$08.00+0     doi:10.1128/CMR.18.1.102-127.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Mistou, M.-Y., Dramsi, S., Brega, S., Poyart, C., Trieu-Cuot, P. (2009). Molecular Dissection of the secA2 Locus of Group B Streptococcus Reveals that Glycosylation of the Srr1 LPXTG Protein Is Required for Full Virulence. J. Bacteriol. 191: 4195-4206 [Abstract] [Full Text]  
  • Murayama, S. Y., Seki, C., Sakata, H., Sunaoshi, K., Nakayama, E., Iwata, S., Sunakawa, K., Ubukata, K., and the Invasive Streptococcal Disease Working Gro, (2009). Capsular Type and Antibiotic Resistance in Streptococcus agalactiae Isolates from Patients, Ranging from Newborns to the Elderly, with Invasive Infections. Antimicrob. Agents Chemother. 53: 2650-2653 [Abstract] [Full Text]  
  • Brochet, M., Couve, E., Bercion, R., Sire, J.-M., Glaser, P. (2009). Population Structure of Human Isolates of Streptococcus agalactiae from Dakar and Bangui. J. Clin. Microbiol. 47: 800-803 [Abstract] [Full Text]  
  • Mavenyengwa, R. T., Maeland, J. A., Moyo, S. R. (2008). Distinctive Features of Surface-Anchored Proteins of Streptococcus agalactiae Strains from Zimbabwe Revealed by PCR and Dot Blotting. CVI 15: 1420-1424 [Abstract] [Full Text]  
  • Kong, F., Lambertsen, L. M., Slotved, H.-C., Ko, D., Wang, H., Gilbert, G. L. (2008). Use of Phenotypic and Molecular Serotype Identification Methods To Characterize Previously Nonserotypeable Group B Streptococci. J. Clin. Microbiol. 46: 2745-2750 [Abstract] [Full Text]  
  • Yang, H.-H., Mascuch, S. J., Madoff, L. C., Paoletti, L. C. (2008). Recombinant Group B Streptococcus Alpha-Like Protein 3 Is an Effective Immunogen and Carrier Protein. CVI 15: 1035-1041 [Abstract] [Full Text]  
  • Sutcliffe, I. C., Black, G. W., Harrington, D. J. (2008). Bioinformatic insights into the biosynthesis of the Group B carbohydrate in Streptococcus agalactiae. Microbiology 154: 1354-1363 [Abstract] [Full Text]  
  • Berlanda Scorza, F., Doro, F., Rodriguez-Ortega, M. J., Stella, M., Liberatori, S., Taddei, A. R., Serino, L., Gomes Moriel, D., Nesta, B., Fontana, M. R., Spagnuolo, A., Pizza, M., Norais, N., Grandi, G. (2008). Proteomics Characterization of Outer Membrane Vesicles from the Extraintestinal Pathogenic Escherichia coli {Delta}tolR IHE3034 Mutant. Mol. Cell. Proteomics 7: 473-485 [Abstract] [Full Text]  
  • Bolduc, G. R., Madoff, L. C. (2007). The group B streptococcal alpha C protein binds {alpha}1 1-integrin through a novel KTD motif that promotes internalization of GBS within human epithelial cells. Microbiology 153: 4039-4049 [Abstract] [Full Text]  
  • Samen, U., Eikmanns, B. J., Reinscheid, D. J., Borges, F. (2007). The Surface Protein Srr-1 of Streptococcus agalactiae Binds Human Keratin 4 and Promotes Adherence to Epithelial HEp-2 Cells. Infect. Immun. 75: 5405-5414 [Abstract] [Full Text]  
  • Gherardi, G., Imperi, M., Baldassarri, L., Pataracchia, M., Alfarone, G., Recchia, S., Orefici, G., Dicuonzo, G., Creti, R. (2007). Molecular Epidemiology and Distribution of Serotypes, Surface Proteins, and Antibiotic Resistance among Group B Streptococci in Italy. J. Clin. Microbiol. 45: 2909-2916 [Abstract] [Full Text]  
  • Yang, H.-H., Madoff, L. C., Guttormsen, H.-K., Liu, Y.-D., Paoletti, L. C. (2007). Recombinant Group B Streptococcus Beta C Protein and a Variant with the Deletion of Its Immunoglobulin A-Binding Site Are Protective Mouse Maternal Vaccines and Effective Carriers in Conjugate Vaccines. Infect. Immun. 75: 3455-3461 [Abstract] [Full Text]  
  • Bierne, H., Cossart, P. (2007). Listeria monocytogenes Surface Proteins: from Genome Predictions to Function. Microbiol. Mol. Biol. Rev. 71: 377-397 [Abstract] [Full Text]  
  • Ho, Y.-R., Li, C.-M., Su, H.-P., Wu, J.-H., Tseng, Y.-C., Lin, Y.-J., Wu, J.-J. (2007). Variation in the Number of Tandem Repeats and Profile of Surface Protein Genes among Invasive Group B Streptococci Correlates with Patient Age. J. Clin. Microbiol. 45: 1634-1636 [Abstract] [Full Text]  
  • Rosenau, A., Martins, K., Amor, S., Gannier, F., Lanotte, P., van der Mee-Marquet, N., Mereghetti, L., Quentin, R. (2007). Evaluation of the Ability of Streptococcus agalactiae Strains Isolated from Genital and Neonatal Specimens To Bind to Human Fibrinogen and Correlation with Characteristics of the fbsA and fbsB Genes. Infect. Immun. 75: 1310-1317 [Abstract] [Full Text]  
  • Larsson, C, Lindroth, M, Nordin, P, Stalhammar-Carlemalm, M, Lindahl, G, Krantz, I (2006). Association between low concentrations of antibodies to protein {alpha} and Rib and invasive neonatal group B streptococcal infection.. Arch. Dis. Child. Fetal Neonatal Ed. 91: F403-F408 [Abstract] [Full Text]  
  • Zeng, X., Kong, F., Morgan, J., Gilbert, G. L. (2006). Evaluation of a Multiplex PCR-Based Reverse Line Blot-Hybridization Assay for Identification of Serotype and Surface Protein Antigens of Streptococcus agalactiae.. J. Clin. Microbiol. 44: 3822-3825 [Abstract] [Full Text]  
  • Ramaswamy, S. V., Ferrieri, P., Flores, A. E., Paoletti, L. C. (2006). Molecular characterization of nontypeable group B streptococcus.. J. Clin. Microbiol. 44: 2398-2403 [Abstract] [Full Text]  
  • Ramaswamy, S. V., Ferrieri, P., Madoff, L. C., Flores, A. E., Kumar, N., Tettelin, H., Paoletti, L. C. (2006). Identification of novel cps locus polymorphisms in nontypable group B Streptococcus. J Med Microbiol 55: 775-783 [Abstract] [Full Text]  
  • Lin, F.-Y. C., Whiting, A., Adderson, E., Takahashi, S., Dunn, D. M., Weiss, R., Azimi, P. H., Philips, J. B. III, Weisman, L. E., Regan, J., Clark, P., Rhoads, G. G., Frasch, C. E., Troendle, J., Moyer, P., Bohnsack, J. F. (2006). Phylogenetic Lineages of Invasive and Colonizing Strains of Serotype III Group B Streptococci from Neonates: a Multicenter Prospective Study. J. Clin. Microbiol. 44: 1257-1261 [Abstract] [Full Text]  
  • Seifert, K. N., Adderson, E. E., Whiting, A. A., Bohnsack, J. F., Crowley, P. J., Brady, L. J. (2006). A unique serine-rich repeat protein (Srr-2) and novel surface antigen ({varepsilon}) associated with a virulent lineage of serotype III Streptococcus agalactiae.. Microbiology 152: 1029-1040 [Abstract] [Full Text]  
  • Seepersaud, R., Needham, R. H. V., Kim, C. S., Jones, A. L. (2006). Abundance of the {delta} Subunit of RNA Polymerase Is Linked to the Virulence of Streptococcus agalactiae. J. Bacteriol. 188: 2096-2105 [Abstract] [Full Text]  
  • Nagano, N., Nagano, Y., Nakano, R., Okamoto, R., Inoue, M. (2006). Genetic diversity of the C protein beta-antigen gene and its upstream regions within clonally related groups of type Ia and Ib group B streptococci.. Microbiology 152: 771-778 [Abstract] [Full Text]  
  • Waldemarsson, J., Areschoug, T., Lindahl, G., Johnsson, E. (2006). The Streptococcal Blr and Slr Proteins Define a Family of Surface Proteins with Leucine-Rich Repeats: Camouflaging by Other Surface Structures. J. Bacteriol. 188: 378-388 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»