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Clinical Microbiology Reviews, January 2005, p. 195-204, Vol. 18, No. 1
0893-8512/05/$08.00+0     doi:10.1128/CMR.18.1.195-204.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Bacterial Contamination of Blood Components

Mark E. Brecher* and Shauna N. Hay

Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina

Blood for transfusion is a potential source of infection by a variety of known and unknown transmissible agents. Over the last 20 years, astounding reductions in the risk of viral infection via allogeneic blood have been achieved. As a result of this success, bacterial contamination of blood products has emerged as the greatest residual source of transfusion-transmitted disease. This paper summarizes the current status of detection, prevention, and elimination of bacteria in blood products for transfusion.

* Corresponding author. Mailing address: Transfusion Medicine Service, CB 7600, University of North Carolina Hospitals, 101 Manning Dr., Chapel Hill, NC 27514. Phone: (919) 966-8465. Fax: (919) 966 5013. E-mail: Brecher{at}med.unc.edu.

Clinical Microbiology Reviews, January 2005, p. 195-204, Vol. 18, No. 1
0893-8512/05/$08.00+0     doi:10.1128/CMR.18.1.195-204.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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