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Clinical Microbiology Reviews, April 2008, p. 274-290, Vol. 21, No. 2
0893-8512/08/$08.00+0     doi:10.1128/CMR.00045-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Respiratory Viruses Other than Influenza Virus: Impact and Therapeutic Advances

W. Garrett Nichols,1 Angela J. Peck Campbell,2,3,4 and Michael Boeckh2,4*

GlaxoSmithKline, London, United Kingdom,1 Program in Infectious Diseases and Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center,2 Children's Hospital and Regional Medical Center,3 University of Washington, Seattle, Washington4

Summary: Though several antivirals have been developed and marketed to treat influenza virus infections, the development of antiviral agents with clinical activity against other respiratory viruses has been more problematic. Here we review the epidemiology of respiratory viral infections in immunocompetent and immunocompromised hosts, examine the evidence surrounding the currently available antivirals for respiratory viral infections other than influenza, highlight those that are in the pipeline, and discuss the hurdles for development of such agents.

* Corresponding author. Mailing address: Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D3-100, Seattle, WA 98109. Phone: (206) 667-6702. Fax: (206) 667-4411. E-mail: mboeckh{at}fhcrc.org

Clinical Microbiology Reviews, April 2008, p. 274-290, Vol. 21, No. 2
0893-8512/08/$08.00+0     doi:10.1128/CMR.00045-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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