This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Peleg, A. Y.
Right arrow Articles by Paterson, D. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Peleg, A. Y.
Right arrow Articles by Paterson, D. L.

 Previous Article

Clinical Microbiology Reviews, July 2008, p. 538-582, Vol. 21, No. 3
0893-8512/08/$08.00+0     doi:10.1128/CMR.00058-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Acinetobacter baumannii: Emergence of a Successful Pathogen

Anton Y. Peleg,1* Harald Seifert,2 and David L. Paterson3,4,5

Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts,1 Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstrasse 19-21, 50935 Cologne, Germany,2 University of Queensland, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia,3 Pathology Queensland, Brisbane, Queensland, Australia,4 Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania5

Acinetobacter baumannii has emerged as a highly troublesome pathogen for many institutions globally. As a consequence of its immense ability to acquire or upregulate antibiotic drug resistance determinants, it has justifiably been propelled to the forefront of scientific attention. Apart from its predilection for the seriously ill within intensive care units, A. baumannii has more recently caused a range of infectious syndromes in military personnel injured in the Iraq and Afghanistan conflicts. This review details the significant advances that have been made in our understanding of this remarkable organism over the last 10 years, including current taxonomy and species identification, issues with susceptibility testing, mechanisms of antibiotic resistance, global epidemiology, clinical impact of infection, host-pathogen interactions, and infection control and therapeutic considerations.

* Corresponding author. Mailing address: Division of Infectious Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, 110 Francis Street, LMOB Suite GB, Boston, MA 02215. Phone: (617) 667-7000. Fax: (617) 632-7626. E-mail: apeleg{at}bidmc.harvard.edu

Clinical Microbiology Reviews, July 2008, p. 538-582, Vol. 21, No. 3
0893-8512/08/$08.00+0     doi:10.1128/CMR.00058-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Srinivasan, V. B., Rajamohan, G., Gebreyes, W. A. (2009). Role of AbeS, a Novel Efflux Pump of the SMR Family of Transporters, in Resistance to Antimicrobial Agents in Acinetobacter baumannii. Antimicrob. Agents Chemother. 53: 5312-5316 [Abstract] [Full Text]  
  • Higgins, P. G., Poirel, L., Lehmann, M., Nordmann, P., Seifert, H. (2009). OXA-143, a Novel Carbapenem-Hydrolyzing Class D {beta}-Lactamase in Acinetobacter baumannii. Antimicrob. Agents Chemother. 53: 5035-5038 [Abstract] [Full Text]  
  • van den Broek, P. J., van der Reijden, T. J. K., van Strijen, E., Helmig-Schurter, A. V., Bernards, A. T., Dijkshoorn, L. (2009). Endemic and Epidemic Acinetobacter Species in a University Hospital: an 8-Year Survey. J. Clin. Microbiol. 47: 3593-3599 [Abstract] [Full Text]  
  • Mostachio, A. K., van der Heidjen, I., Rossi, F., Levin, A. S., Costa, S. F. (2009). Multiplex PCR for rapid detection of genes encoding oxacillinases and metallo-{beta}-lactamases in carbapenem-resistant Acinetobacter spp.. J Med Microbiol 58: 1522-1524 [Full Text]  
  • Kohlenberg, A., Brummer, S., Higgins, P. G., Sohr, D., Piening, B. C., de Grahl, C., Halle, E., Ruden, H., Seifert, H. (2009). Outbreak of carbapenem-resistant Acinetobacter baumannii carrying the carbapenemase OXA-23 in a German university medical centre. J Med Microbiol 58: 1499-1507 [Abstract] [Full Text]  
  • Choi, A. H. K., Slamti, L., Avci, F. Y., Pier, G. B., Maira-Litran, T. (2009). The pgaABCD Locus of Acinetobacter baumannii Encodes the Production of Poly-{beta}-1-6-N-Acetylglucosamine, Which Is Critical for Biofilm Formation. J. Bacteriol. 191: 5953-5963 [Abstract] [Full Text]  
  • Adams, M. D., Nickel, G. C., Bajaksouzian, S., Lavender, H., Murthy, A. R., Jacobs, M. R., Bonomo, R. A. (2009). Resistance to Colistin in Acinetobacter baumannii Associated with Mutations in the PmrAB Two-Component System. Antimicrob. Agents Chemother. 53: 3628-3634 [Abstract] [Full Text]  
  • Livermore, D. M. (2009). Has the era of untreatable infections arrived?. J Antimicrob Chemother 64: i29-i36 [Abstract] [Full Text]  
  • Gaddy, J. A., Tomaras, A. P., Actis, L. A. (2009). The Acinetobacter baumannii 19606 OmpA Protein Plays a Role in Biofilm Formation on Abiotic Surfaces and in the Interaction of This Pathogen with Eukaryotic Cells. Infect. Immun. 77: 3150-3160 [Abstract] [Full Text]  
  • Chen, Y., Pi, B., Zhou, H., Yu, Y., Li, L. (2009). Triclosan resistance in clinical isolates of Acinetobacter baumannii. J Med Microbiol 58: 1086-1091 [Abstract] [Full Text]  
  • Figueiredo, S., Poirel, L., Croize, J., Recule, C., Nordmann, P. (2009). In Vivo Selection of Reduced Susceptibility to Carbapenems in Acinetobacter baumannii Related to ISAba1-Mediated Overexpression of the Natural blaOXA-66 Oxacillinase Gene. Antimicrob. Agents Chemother. 53: 2657-2659 [Abstract] [Full Text]  
  • Peleg, A. Y., Jara, S., Monga, D., Eliopoulos, G. M., Moellering, R. C. Jr., Mylonakis, E. (2009). Galleria mellonella as a Model System To Study Acinetobacter baumannii Pathogenesis and Therapeutics. Antimicrob. Agents Chemother. 53: 2605-2609 [Abstract] [Full Text]  
  • Post, V., Hall, R. M. (2009). AbaR5, a Large Multiple-Antibiotic Resistance Region Found in Acinetobacter baumannii. Antimicrob. Agents Chemother. 53: 2667-2671 [Abstract] [Full Text]  
  • Hujer, K. M., Hujer, A. M., Endimiani, A., Thomson, J. M., Adams, M. D., Goglin, K., Rather, P. N., Pennella, T.-T. D., Massire, C., Eshoo, M. W., Sampath, R., Blyn, L. B., Ecker, D. J., Bonomo, R. A. (2009). Rapid Determination of Quinolone Resistance in Acinetobacter spp.. J. Clin. Microbiol. 47: 1436-1442 [Abstract] [Full Text]  
  • Giannouli, M., Tomasone, F., Agodi, A., Vahaboglu, H., Daoud, Z., Triassi, M., Tsakris, A., Zarrilli, R. (2009). Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii strains in intensive care units of multiple Mediterranean hospitals. J Antimicrob Chemother 63: 828-830 [Full Text]  
  • Peleg, A. Y., Tilahun, Y., Fiandaca, M. J., D'Agata, E. M. C., Venkataraman, L., Moellering, R. C. Jr., Eliopoulos, G. M. (2009). Utility of Peptide Nucleic Acid Fluorescence In Situ Hybridization for Rapid Detection of Acinetobacter spp. and Pseudomonas aeruginosa. J. Clin. Microbiol. 47: 830-832 [Abstract] [Full Text]  
  • Arroyo, L. A., Mateos, I., Gonzalez, V., Aznar, J. (2009). In Vitro Activities of Tigecycline, Minocycline, and Colistin-Tigecycline Combination against Multi- and Pandrug-Resistant Clinical Isolates of Acinetobacter baumannii Group. Antimicrob. Agents Chemother. 53: 1295-1296 [Full Text]  
  • Adams-Haduch, J. M., Paterson, D. L., Sidjabat, H. E., Pasculle, A. W., Potoski, B. A., Muto, C. A., Harrison, L. H., Doi, Y. (2008). Genetic Basis of Multidrug Resistance in Acinetobacter baumannii Clinical Isolates at a Tertiary Medical Center in Pennsylvania. Antimicrob. Agents Chemother. 52: 3837-3843 [Abstract] [Full Text]  
  • Peleg, A. Y., Tampakakis, E., Fuchs, B. B., Eliopoulos, G. M., Moellering, R. C. Jr., Mylonakis, E. (2008). Prokaryote-eukaryote interactions identified by using Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 105: 14585-14590 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»