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Clinical Microbiology Reviews, January 2009, p. 76-98, Vol. 22, No. 1
0893-8512/09/$08.00+0     doi:10.1128/CMR.00034-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Immunobiology of Human Cytomegalovirus: from Bench to Bedside

Tania Crough and Rajiv Khanna*

Australian Centre for Vaccine Development and Tumour Immunology Laboratory, Division of Immunology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia

Summary: Following primary infection, human cytomegalovirus (HCMV) establishes lifelong latency and periodically reactivates without causing symptoms in healthy individuals. In the absence of an adequate host-derived immune response, this fine balance of permitting viral reactivation without causing pathogenesis is disrupted, and HCMV can subsequently cause invasive disease and an array of damaging indirect immunological effects. Over the last decade, our knowledge of the immune response to HCMV infection in healthy virus carriers and diseased individuals has allowed us to translate these findings to develop better diagnostic tools and therapeutic strategies. The application of these emerging technologies in the clinical setting is likely to provide opportunities for better management of patients with HCMV-associated diseases.

* Corresponding author. Mailing address: Tumour Immunology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston (Qld) 4006, Australia. Phone: 61-7-3362 0385. Fax: 61-7-3845 3510. E-mail: rajiv.khanna{at}qimr.edu.au

Clinical Microbiology Reviews, January 2009, p. 76-98, Vol. 22, No. 1
0893-8512/09/$08.00+0     doi:10.1128/CMR.00034-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Smith, C., Wakisaka, N., Crough, T., Peet, J., Yoshizaki, T., Beagley, L., Khanna, R. (2009). Discerning regulation of cis- and trans-presentation of CD8+ T-cell epitopes by EBV-encoded oncogene LMP-1 through self-aggregation. Blood 113: 6148-6152 [Abstract] [Full Text]  


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