This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Google Scholar
Right arrow Articles by Dagenais, T. R. T.
Right arrow Articles by Keller, N. P.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dagenais, T. R. T.
Right arrow Articles by Keller, N. P.

 Previous Article  |  Next Article 

Clinical Microbiology Reviews, July 2009, p. 447-465, Vol. 22, No. 3
0893-8512/09/$08.00+0     doi:10.1128/CMR.00055-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis

Taylor R. T. Dagenais1 and Nancy P. Keller1,2* Author Bios

Medical Microbiology and Immunology, University of Wisconsin—Madison, Madison, Wisconsin,1 Bacteriology, University of Wisconsin—Madison, Madison, Wisconsin2

Summary: Aspergillus species are globally ubiquitous saprophytes found in a variety of ecological niches. Almost 200 species of aspergilli have been identified, less than 20 of which are known to cause human disease. Among them, Aspergillus fumigatus is the most prevalent and is largely responsible for the increased incidence of invasive aspergillosis (IA) in the immunocompromised patient population. IA is a devastating illness, with mortality rates in some patient groups reaching as high as 90%. Studies identifying and assessing the roles of specific factors of A. fumigatus that contribute to the pathogenesis of IA have traditionally focused on single-gene deletion and mutant characterization. In combination with recent large-scale approaches analyzing global fungal responses to distinct environmental or host conditions, these studies have identified many factors that contribute to the overall pathogenic potential of A. fumigatus. Here, we provide an overview of the significant findings regarding A. fumigatus pathogenesis as it pertains to invasive disease.

* Corresponding author. Mailing address: University of Wisconsin—Madison, 3467 Microbial Sciences Building, 1550 Linden Drive, Madison, WI 53706. Phone: (608) 262-9795. Fax: (608) 263-2626. E-mail: npkeller{at}wisc.edu

Clinical Microbiology Reviews, July 2009, p. 447-465, Vol. 22, No. 3
0893-8512/09/$08.00+0     doi:10.1128/CMR.00055-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»