This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sepkowitz, K. A.
Right arrow Articles by Armstrong, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sepkowitz, K. A.
Right arrow Articles by Armstrong, D.

 Previous Article  |  Next Article 

Clinical Microbiology Reviews, Apr 1995, 180-199, Vol 8, No. 2
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

Tuberculosis in the AIDS era

KA Sepkowitz, J Raffalli, L Riley, TE Kiehn and D Armstrong
Infectious Disease Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

A resurgence of tuberculosis has occurred in recent years in the United States and abroad. Deteriorating public health services, increasing numbers of immigrants from countries of endemicity, and coinfection with the human immunodeficiency virus (HIV) have contributed to the rise in the number of cases diagnosed in the United States. Outbreaks of resistant tuberculosis, which responds poorly to therapy, have occurred in hospitals and other settings, affecting patients and health care workers. This review covers the pathogenesis, epidemiology, clinical presentation, laboratory diagnosis, and treatment of Mycobacterium tuberculosis infection and disease. In addition, public health and hospital infection control strategies are detailed. Newer approaches to epidemiologic investigation, including use of restriction fragment length polymorphism analysis, are discussed. Detailed consideration of the interaction between HIV infection and tuberculosis is given. We also review the latest techniques in laboratory evaluation, including the radiometric culture system, DNA probes, and PCR. Current recommendations for therapy of tuberculosis, including multidrug-resistant tuberculosis, are given. Finally, the special problem of prophylaxis of persons exposed to multidrug-resistant tuberculosis is considered.


This article has been cited by other articles:

  • Mahon, R. N., Rojas, R. E., Fulton, S. A., Franko, J. L., Harding, C. V., Boom, W. H. (2009). Mycobacterium tuberculosis Cell Wall Glycolipids Directly Inhibit CD4+ T-Cell Activation by Interfering with Proximal T-Cell-Receptor Signaling. Infect. Immun. 77: 4574-4583 [Abstract] [Full Text]  
  • Havlir, D. V., Getahun, H., Sanne, I., Nunn, P. (2008). Opportunities and Challenges for HIV Care in Overlapping HIV and TB Epidemics. JAMA 300: 423-430 [Abstract] [Full Text]  
  • Mathema, B., Kurepina, N. E., Bifani, P. J., Kreiswirth, B. N. (2006). Molecular Epidemiology of Tuberculosis: Current Insights. Clin. Microbiol. Rev. 19: 658-685 [Abstract] [Full Text]  
  • Xu, J., Wan, E., Kim, C.-J., Floss, H. G., Mahmud, T. (2005). Identification of tailoring genes involved in the modification of the polyketide backbone of rifamycin B by Amycolatopsis mediterranei S699. Microbiology 151: 2515-2528 [Abstract] [Full Text]  
  • Ballell, L., Field, R. A., Duncan, K., Young, R. J. (2005). New Small-Molecule Synthetic Antimycobacterials. Antimicrob. Agents Chemother. 49: 2153-2163 [Full Text]  
  • Kerleguer, A., Fabre, M., Bernatas, J. J., Gerome, P., Nicand, E., Herve, V., Koeck, J. L. (2004). Clinical Evaluation of the Gen-Probe Amplified Mycobacterium Tuberculosis Direct Test for Rapid Diagnosis of Tuberculosis Lymphadenitis. J. Clin. Microbiol. 42: 5921-5922 [Abstract] [Full Text]  
  • Cloud, J. L., Shutt, C., Aldous, W., Woods, G. (2004). Evaluation of a Modified Gen-Probe Amplified Direct Test for Detection of Mycobacterium tuberculosis Complex Organisms in Cerebrospinal Fluid. J. Clin. Microbiol. 42: 5341-5344 [Abstract] [Full Text]  
  • Dannaoui, E., Lortholary, O., Dromer, F. (2004). In Vitro Evaluation of Double and Triple Combinations of Antifungal Drugs against Aspergillus fumigatus and Aspergillus terreus. Antimicrob. Agents Chemother. 48: 970-978 [Abstract] [Full Text]  
  • Garcia, L., Alonso-Sanz, M., Rebollo, M. J., Tercero, J. C., Chaves, F. (2001). Mutations in the rpoB Gene of Rifampin-Resistant Mycobacterium tuberculosis Isolates in Spain and Their Rapid Detection by PCR-Enzyme-Linked Immunosorbent Assay. J. Clin. Microbiol. 39: 1813-1818 [Abstract] [Full Text]  
  • Yu, T.-W., Shen, Y., Doi-Katayama, Y., Tang, L., Park, C., Moore, B. S., Richard Hutchinson, C., Floss, H. G. (1999). Direct evidence that the rifamycin polyketide synthase assembles polyketide chains processively. Proc. Natl. Acad. Sci. USA 96: 9051-9056 [Abstract] [Full Text]  
  • Adams, L. B., Sinha, I., Franzblau, S. G., Krahenbuhl, J. L., Mehta, R. T. (1999). Effective Treatment of Acute and Chronic Murine Tuberculosis with Liposome-Encapsulated Clofazimine. Antimicrob. Agents Chemother. 43: 1638-1643 [Abstract] [Full Text]  
  • Oleksijew, A., Meulbroek, J., Ewing, P., Jarvis, K., Mitten, M., Paige, L., Tovcimak, A., Nukkula, M., Chu, D., Alder, J. D. (1998). In Vivo Efficacy of ABT-255 against Drug-Sensitive and -Resistant Mycobacterium tuberculosis Strains. Antimicrob. Agents Chemother. 42: 2674-2677 [Abstract] [Full Text]  
  • Fattorini, L., Xiao, Y., Mattei, M., Li, Y., Iona, E., Ricci, M. L., Thoresen, O. F., Creti, R., Orefici, G. (1998). Activities of Isoniazid Alone and in Combination with Other Drugs against Mycobacterium avium Infection in Beige Mice. Antimicrob. Agents Chemother. 42: 712-714 [Abstract] [Full Text]  
  • Walter, N. G., Schwille, P., Eigen, M. (1996). Fluorescence correlation analysis of probe diffusion simplifies quantitative pathogen detection by PCR. Proc. Natl. Acad. Sci. USA 93: 12805-12810 [Abstract] [Full Text]  
  • Yu, T.-W., Muller, R., Muller, M., Zhang, X., Draeger, G., Kim, C.-G., Leistner, E., Floss, H. G. (2001). Mutational Analysis and Reconstituted Expression of the Biosynthetic Genes Involved in the Formation of 3-Amino-5-hydroxybenzoic Acid, the Starter Unit of Rifamycin Biosynthesis in Amycolatopsis mediterranei S699. J. Biol. Chem. 276: 12546-12555 [Abstract] [Full Text]  


Copyright © 2010 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»