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Clinical Microbiology Reviews, 10 1995, 496-514, Vol 8, No. 4
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

Antimicrobial agent resistance in mycobacteria: molecular genetic insights

JM Musser
Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA.

The primary theme emerging from molecular genetic work conducted with Mycobacterium tuberculosis and several other mycobacterial species is that resistance is commonly associated with simple nucleotide alterations in target chromosomal genes rather than with acquisition of new genetic elements encoding antibiotic-altering enzymes. Mutations in an 81-bp region of the gene (rpoB) encoding the beta subunit of RNA polymerase account for rifampin resistance in 96% of M. tuberculosis and many Mycobacterium leprae isolates. Streptomycin resistance in about one-half of M. tuberculosis isolates is associated with missense mutations in the rpsL gene coding for ribosomal protein S12 or nucleotide substitutions in the 16S rRNA gene (rrs). Mutations in the katG gene resulting in catalase-peroxidase amino acid alterations nad nucleotide substitutions in the presumed regulatory region of the inhA locus are repeatedly associated with isoniazid-resistant M. tuberculosis isolates. A majority of fluoroquinolone-resistant M. tuberculosis isolates have amino acid substitutions in a region of the DNA gyrase A subunit homologous to a conserved fluoroquinolone resistance-determining region. Multidrug-resistant isolates of M. tuberculosis arise as a consequence of sequential accumulation of mutations conferring resistance to single therapeutic agents. Molecular strategies show considerable promise for rapid detection of mutations associated with antimicrobial resistance. These approaches are now amenable to utilization in an appropriately equipped clinical microbiology laboratory.


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  • Ardito, F., Posteraro, B., Sanguinetti, M., Zanetti, S., Fadda, G. (2001). Evaluation of BACTEC Mycobacteria Growth Indicator Tube (MGIT 960) Automated System for Drug Susceptibility Testing of Mycobacterium tuberculosis. J. Clin. Microbiol. 39: 4440-4444 [Abstract] [Full Text]  
  • El-Hajj, H. H., Marras, S. A. E., Tyagi, S., Kramer, F. R., Alland, D. (2001). Detection of Rifampin Resistance in Mycobacterium tuberculosis in a Single Tube with Molecular Beacons. J. Clin. Microbiol. 39: 4131-4137 [Abstract] [Full Text]  
  • Springer, B., Kidan, Y. G., Prammananan, T., Ellrott, K., Bottger, E. C., Sander, P. (2001). Mechanisms of Streptomycin Resistance: Selection of Mutations in the 16S rRNA Gene Conferring Resistance. Antimicrob. Agents Chemother. 45: 2877-2884 [Abstract] [Full Text]  
  • Bartfai, Z., Somoskovi, A., Kodmon, C., Szabo, N., Puskas, E., Kosztolanyi, L., Farago, E., Mester, J., Parsons, L. M., Salfinger, M. (2001). Molecular Characterization of Rifampin-Resistant Isolates of Mycobacterium tuberculosis from Hungary by DNA Sequencing and the Line Probe Assay. J. Clin. Microbiol. 39: 3736-3739 [Abstract] [Full Text]  
  • Florczyk, M. A., McCue, L. A., Stack, R. F., Hauer, C. R., McDonough, K. A. (2001). Identification and Characterization of Mycobacterial Proteins Differentially Expressed under Standing and Shaking Culture Conditions, Including Rv2623 from a Novel Class of Putative ATP-Binding Proteins. Infect. Immun. 69: 5777-5785 [Abstract] [Full Text]  
  • Fines, M., Pronost, S., Maillard, K., Taouji, S., Leclercq, R. (2001). Characterization of Mutations in the rpoB Gene Associated with Rifampin Resistance in Rhodococcus equi Isolated from Foals. J. Clin. Microbiol. 39: 2784-2787 [Abstract] [Full Text]  
  • Mani, C., Selvakumar, N., Narayanan, S., Narayanan, P. R. (2001). Mutations in the rpoB Gene of Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates from India. J. Clin. Microbiol. 39: 2987-2990 [Abstract] [Full Text]  
  • Mikhailovich, V., Lapa, S., Gryadunov, D., Sobolev, A., Strizhkov, B., Chernyh, N., Skotnikova, O., Irtuganova, O., Moroz, A., Litvinov, V., Vladimirskii, M., Perelman, M., Chernousova, L., Erokhin, V., Zasedatelev, A., Mirzabekov, A. (2001). Identification of Rifampin-Resistant Mycobacterium tuberculosis Strains by Hybridization, PCR, and Ligase Detection Reaction on Oligonucleotide Microchips. J. Clin. Microbiol. 39: 2531-2540 [Abstract] [Full Text]  
  • Master, S., Zahrt, T. C., Song, J., Deretic, V. (2001). Mapping of Mycobacterium tuberculosis katG Promoters and Their Differential Expression in Infected Macrophages. J. Bacteriol. 183: 4033-4039 [Abstract] [Full Text]  
  • Sechi, L. A., Zanetti, S., Sanguinetti, M., Molicotti, P., Romano, L., Leori, G., Delogu, G., Boccia, S., La Sorda, M., Fadda, G. (2001). Molecular Basis of Rifampin and Isoniazid Resistance in Mycobacterium bovis Strains Isolated in Sardinia, Italy. Antimicrob. Agents Chemother. 45: 1645-1648 [Abstract] [Full Text]  
  • Garcia, L., Alonso-Sanz, M., Rebollo, M. J., Tercero, J. C., Chaves, F. (2001). Mutations in the rpoB Gene of Rifampin-Resistant Mycobacterium tuberculosis Isolates in Spain and Their Rapid Detection by PCR-Enzyme-Linked Immunosorbent Assay. J. Clin. Microbiol. 39: 1813-1818 [Abstract] [Full Text]  
  • Reynolds, M. G. (2000). Compensatory Evolution in Rifampin-Resistant Escherichia coli. Genetics 156: 1471-1481 [Abstract] [Full Text]  
  • Olakanmi, O., Britigan, B. E., Schlesinger, L. S. (2000). Gallium Disrupts Iron Metabolism of Mycobacteria Residing within Human Macrophages. Infect. Immun. 68: 5619-5627 [Abstract] [Full Text]  
  • DeBarber, A. E., Mdluli, K., Bosman, M., Bekker, L.-G., Barry, C. E. 3rd (2000). Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA 97: 9677-9682 [Abstract] [Full Text]  
  • Valim, A. R. M., Rossetti, M. L. R., Ribeiro, M. O., Zaha, A. (2000). Mutations in the rpoB Gene of Multidrug-Resistant Mycobacterium tuberculosis Isolates from Brazil. J. Clin. Microbiol. 38: 3119-3122 [Abstract] [Full Text]  
  • Karunakaran, P., Davies, J. (2000). Genetic Antagonism and Hypermutability in Mycobacterium smegmatis. J. Bacteriol. 182: 3331-3335 [Abstract] [Full Text]  
  • Heep, M., Odenbreit, S., Beck, D., Decker, J., Prohaska, E., Rieger, U., Lehn, N. (2000). Mutations at Four Distinct Regions of the rpoB Gene Can Reduce the Susceptibility of Helicobacter pylori to Rifamycins. Antimicrob. Agents Chemother. 44: 1713-1715 [Abstract] [Full Text]  
  • Heep, M., Rieger, U., Beck, D., Lehn, N. (2000). Mutations in the Beginning of the rpoB Gene Can Induce Resistance to Rifamycins in both Helicobacter pylori and Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 44: 1075-1077 [Abstract] [Full Text]  
  • DROBNIEWSKI, F.A., WATTERSON, S.A., WILSON, S.M., HARRIS, G.S. (2000). A clinical, microbiological and economic analysis of a national service for the rapid molecular diagnosis of tuberculosis and rifampicin resistance in Mycobacterium tuberculosis. J Med Microbiol 49: 271-278 [Abstract] [Full Text]  
  • BEECHING, N.J., HART, C.A., DUERDEN, B.I. (2000). Tropical and exotic infections: Proceedings of the fifth Liverpool Tropical School Bayer Symposium on Microbial Diseases held on 14 February 1998. J Med Microbiol 49: 5-27 [Full Text]  
  • Scarpellini, P., Braglia, S., Carrera, P., Cedri, M., Cichero, P., Colombo, A., Crucianelli, R., Gori, A., Ferrari, M., Lazzarin, A. (1999). Detection of Rifampin Resistance in Mycobacterium tuberculosis by Double Gradient-Denaturing Gradient Gel Electrophoresis. Antimicrob. Agents Chemother. 43: 2550-2554 [Abstract] [Full Text]  
  • Wilson, R. W., Yang, Z., Kelley, M., Cave, M. D., Pogoda, J. M., Wallace, R. J. Jr., Cegielski, J. P., Dunbar, D. F., Bergmire-Sweat, D., Elliott, L. B., Barnes, P. F. (1999). Evidence from Molecular Fingerprinting of Limited Spread of Drug-Resistant Tuberculosis in Texas. J. Clin. Microbiol. 37: 3255-3259 [Abstract] [Full Text]  
  • Billington, O. J., McHugh, T. D., Gillespie, S. H. (1999). Physiological Cost of Rifampin Resistance Induced In Vitro in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 43: 1866-1869 [Abstract] [Full Text]  
  • Rhee, J. T., Piatek, A. S., Small, P. M., Harris, L. M., Chaparro, S. V., Kramer, F. R., Alland, D. (1999). Molecular Epidemiologic Evaluation of Transmissibility and Virulence of Mycobacterium tuberculosis. J. Clin. Microbiol. 37: 1764-1770 [Abstract] [Full Text]  
  • Fang, Z., Doig, C., Rayner, A., Kenna, D. T., Watt, B., Forbes, K. J. (1999). Molecular Evidence for Heterogeneity of the Multiple-Drug-Resistant Mycobacterium tuberculosis Population in Scotland (1990 to 1997). J. Clin. Microbiol. 37: 998-1003 [Abstract] [Full Text]  
  • Riska, P. F., Su, Y., Bardarov, S., Freundlich, L., Sarkis, G., Hatfull, G., Carrière, C., Kumar, V., Chan, J., Jacobs, W. R. Jr. (1999). Rapid Film-Based Determination of Antibiotic Susceptibilities of Mycobacterium tuberculosis Strains by Using a Luciferase Reporter Phage and the Bronx Box. J. Clin. Microbiol. 37: 1144-1149 [Abstract] [Full Text]  
  • Pozzi, G., Meloni, M., Iona, E., Orrù, G., Thoresen, O. F., Ricci, M. L., Oggioni, M. R., Fattorini, L., Orefici, G. (1999). rpoB Mutations in Multidrug-Resistant Strains of Mycobacterium tuberculosis Isolated in Italy. J. Clin. Microbiol. 37: 1197-1199 [Abstract] [Full Text]  
  • Hellyer, T. J., DesJardin, L. E., Teixeira, L., Perkins, M. D., Cave, M. D., Eisenach, K. D. (1999). Detection of Viable Mycobacterium tuberculosis by Reverse Transcriptase-Strand Displacement Amplification of mRNA. J. Clin. Microbiol. 37: 518-523 [Abstract] [Full Text]  
  • Michele, T. M., Ko, C., Bishai, W. R. (1999). Exposure to Antibiotics Induces Expression of the Mycobacterium tuberculosis sigF Gene: Implications for Chemotherapy against Mycobacterial Persistors. Antimicrob. Agents Chemother. 43: 218-225 [Abstract] [Full Text]  
  • Hellyer, T. J., DesJardin, L. E., Hehman, G. L., Cave, M. D., Eisenach, K. D. (1999). Quantitative Analysis of mRNA as a Marker for Viability of Mycobacterium tuberculosis. J. Clin. Microbiol. 37: 290-295 [Abstract] [Full Text]  
  • McDonnell, G., Russell, A. D. (1999). Antiseptics and Disinfectants: Activity, Action, and Resistance. Clin. Microbiol. Rev. 12: 147-179 [Abstract] [Full Text]  
  • Aínsa, J. A., Blokpoel, M. C. J., Otal, I., Young, D. B., De Smet, K. A. L., Martín, C. (1998). Molecular Cloning and Characterization of Tap, a Putative Multidrug Efflux Pump Present in Mycobacterium fortuitum and Mycobacterium tuberculosis. J. Bacteriol. 180: 5836-5843 [Abstract] [Full Text]  
  • De Rossi, E., Branzoni, M., Cantoni, R., Milano, A., Riccardi, G., Ciferri, O. (1998). mmr, a Mycobacterium tuberculosis Gene Conferring Resistance to Small Cationic Dyes and Inhibitors. J. Bacteriol. 180: 6068-6071 [Abstract] [Full Text]  
  • Pagán-Ramos, E., Song, J., McFalone, M., Mudd, M. H., Deretic, V. (1998). Oxidative Stress Response and Characterization of the oxyR-ahpC and furA-katG Loci in Mycobacterium marinum. J. Bacteriol. 180: 4856-4864 [Abstract] [Full Text]  
  • Hawkey, P. M (1998). The origins and molecular basis of antibiotic resistance. BMJ 317: 657-660 [Full Text]  
  • Williams, D. L., Spring, L., Collins, L., Miller, L. P., Heifets, L. B., Gangadharam, P. R. J., Gillis, T. P. (1998). Contribution of rpoB Mutations to Development of Rifamycin Cross-Resistance in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 42: 1853-1857 [Abstract] [Full Text]  
  • RIDZON, R., WHITNEY, C. G., MCKENNA, M. T., TAYLOR, J. P., ASHKAR, S. H., NITTA, A. T., HARVEY, S. M., VALWAY, S., WOODLEY, C., COOKSEY, R., ONORATO, I. M. (1998). Risk Factors for Rifampin Mono-resistant Tuberculosis. Am. J. Respir. Crit. Care Med. 157: 1881-1884 [Abstract] [Full Text]  
  • Gingeras, T. R., Ghandour, G., Wang, E., Berno, A., Small, P. M., Drobniewski, F., Alland, D., Desmond, E., Holodniy, M., Drenkow, J. (1998). Simultaneous Genotyping and Species Identification Using Hybridization Pattern Recognition Analysis of Generic Mycobacterium DNA Arrays. Genome Res 8: 435-448 [Abstract] [Full Text]  
  • Matsiota-Bernard, P, Vrioni, G, Marinis, E (1998). Characterization of rpoB mutations in rifampin-resistant clinical Mycobacterium tuberculosis isolates from Greece [In Process Citation]. J. Clin. Microbiol. 36: 20-23 [Abstract] [Full Text]  
  • Sreevatsan, S., Pan, X., Stockbauer, K. E., Connell, N. D., Kreiswirth, B. N., Whittam, T. S., Musser, J. M. (1997). Restricted structural gene polymorphism in the Mycobacterium tuberculosis complex indicates evolutionarily recent global dissemination. Proc. Natl. Acad. Sci. USA 94: 9869-9874 [Abstract] [Full Text]  
  • Zhang, Y., Dhandayuthapani, S., Deretic, V. (1996). Molecular basis for the exquisite sensitivity of Mycobacterium tuberculosis to isoniazid. Proc. Natl. Acad. Sci. USA 93: 13212-13216 [Abstract] [Full Text]  
  • Bifani, P. J., Plikaytis, B. B., Kapur, V., Stockbauer, K., Pan, X., Lutfey, M. L., Moghazeh, S. L., Eisner, W., Daniel, T. M., Kaplan, M. H., Crawford, J. T., Musser, J. M., Kreiswirth, B. N. (1996). Origin and Interstate Spread of a New York City Multidrug-Resistant Mycobacterium tuberculosis Clone Family. JAMA 275: 452-457 [Abstract]  


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