This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Saubolle, M. A.
Right arrow Articles by Armstrong, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Saubolle, M. A.
Right arrow Articles by Armstrong, D.

Next Article 

Clinical Microbiology Reviews, Oct 1996, 435-447, Vol 9, No. 4
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Mycobacterium haemophilum: microbiology and expanding clinical and geographic spectra of disease in humans

MA Saubolle, TE Kiehn, MH White, MF Rudinsky and D Armstrong
Department of Pathology, Good Samaritan Regional Medical Center, Phoenix, Arizona 85006, USA.

Reports of the association of Mycobacterium haemophilum with disease in humans have greatly increased. At least 64 cases have now been reported, with symptoms ranging from focal lesions to widespread, systemic disease. The organism is now known to cause primarily cutaneous and subcutaneous infection, septic arthritis, osteomyelitis, and pneumonitis in patients who are immunologically compromised and lymphadenitis in apparently immunocompetent children. Underlying conditions in the compromised patients have included AIDS; renal, bone marrow, and cardiac transplantation; lymphoma; rheumatoid arthritis; marrow hypoplasia; and Crohn's disease. Reports have originated from diverse geographic areas worldwide. The epidemiology of M. haemophilum remains poorly defined; there appears to be a genetic diversity between strains isolated from different regions. The organism is probably present in the environment, but recovery by sampling has not been successful. M. haemophilum has several unique traits, including predilection for lower temperatures (30 to 32 degrees C) and requirement for iron supplementation (ferric ammonium citrate or hemin). These may in the past have compromised recovery in the laboratory. Therapy has not been well elucidated, and the outcome appears to be influenced by the patient's underlying immunosuppression. The organisms are most susceptible to ciprofloxacin, clarithromycin, rifabutin, and rifampin. Timely diagnosis and therapy require communication between clinician and the laboratory.


This article has been cited by other articles:

  • Keller, M., Mak, A., Thibert, L., Rene, P., Klein, M. B. (2008). Mycobacterium haemophilum Epididymal Abscess in a Renal Transplant Patient. J. Clin. Microbiol. 46: 2459-2460 [Abstract] [Full Text]  
  • Jang, E.-Y., Lee, S.-O., Choi, S.-H., Sung, H., Kim, M.-N., Kim, B.-J., Choi, S.-H., Kim, Y. S., Woo, J. H. (2007). Case of Pyomyositis Due to Mycobacterium haemophilum in a Renal Transplant Recipient. J. Clin. Microbiol. 45: 3847-3849 [Abstract] [Full Text]  
  • Griffith, D. E., Aksamit, T., Brown-Elliott, B. A., Catanzaro, A., Daley, C., Gordin, F., Holland, S. M., Horsburgh, R., Huitt, G., Iademarco, M. F., Iseman, M., Olivier, K., Ruoss, S., von Reyn, C. F., Wallace, R. J. Jr., Winthrop, K., on behalf of the ATS Mycobacterial Diseases Subcom, (2007). An Official ATS/IDSA Statement: Diagnosis, Treatment, and Prevention of Nontuberculous Mycobacterial Diseases. Am. J. Respir. Crit. Care Med. 175: 367-416 [Full Text]  
  • Jacob, B., DeBey, B. M., Bradway, D. (2006). Spinal Intradural Mycobacterium haemophilum Granuloma in an American Bison (Bison bison).. Vet Pathol 43: 998-1000 [Abstract] [Full Text]  
  • Wallace, R. J. Jr., Brown-Elliott, B. A., Brown, J., Steigerwalt, A. G., Hall, L., Woods, G., Cloud, J., Mann, L., Wilson, R., Crist, C., Jost, K. C. Jr., Byrer, D. E., Tang, J., Cooper, J., Stamenova, E., Campbell, B., Wolfe, J., Turenne, C. (2005). Polyphasic Characterization Reveals that the Human Pathogen Mycobacterium peregrinum Type II Belongs to the Bovine Pathogen Species Mycobacterium senegalense. J. Clin. Microbiol. 43: 5925-5935 [Abstract] [Full Text]  
  • (2005). Chronic Infiltrates and Persisting Ulcerations on the Arms and Legs--Diagnosis. Arch Dermatol 141: 897-902 [Full Text]  
  • Miranda-CasoLuengo, R., Duffy, P. S., O'Connell, E. P., Graham, B. J., Mangan, M. W., Prescott, J. F., Meijer, W. G. (2005). The Iron-Regulated iupABC Operon Is Required for Saprophytic Growth of the Intracellular Pathogen Rhodococcus equi at Low Iron Concentrations. J. Bacteriol. 187: 3438-3444 [Abstract] [Full Text]  
  • Wang, S. X., Sng, L. H., Leong, H. N., Tan, B. H. (2004). Direct Identification of Mycobacterium haemophilum in Skin Lesions of Immunocompromised Patients by PCR-Restriction Endonuclease Analysis. J. Clin. Microbiol. 42: 3336-3338 [Abstract] [Full Text]  
  • Geisler, W. M., Harrington, R. D., Wallis, C. K., Harnisch, J. P., Liles, W. C. (2002). Broad Spectrum of Dermatologic Manifestations Caused by Mycobacterium haemophilum Infection. Arch Dermatol 138: 229-230 [Full Text]  
  • Kim, B.-J., Lee, K.-H., Park, B.-N., Kim, S.-J., Bai, G.-H., Kim, S.-J., Kook, Y.-H. (2001). Differentiation of Mycobacterial Species by PCR-Restriction Analysis of DNA (342 Base Pairs) of the RNA Polymerase Gene (rpoB). J. Clin. Microbiol. 39: 2102-2109 [Abstract] [Full Text]  
  • Kellogg, J. A., Bankert, D. A., Withers, G. S., Sweimler, W., Kiehn, T. E., Pfyffer, G. E. (2001). Application of the Sherlock Mycobacteria Identification System Using High-Performance Liquid Chromatography in a Clinical Laboratory. J. Clin. Microbiol. 39: 964-970 [Abstract] [Full Text]  
  • MALOUF, M. A., GLANVILLE, A. R. (1999). The Spectrum of Mycobacterial Infection after Lung Transplantation. Am. J. Respir. Crit. Care Med. 160: 1611-1616 [Abstract] [Full Text]  
  • WHITE, D. A., KIEHN, T. E., BONDOC, A. Y., MASSARELLA, S. A. (1999). Pulmonary Nodule due to Mycobacterium haemophilum in an Immunocompetent Host. Am. J. Respir. Crit. Care Med. 160: 1366-1368 [Abstract] [Full Text]  
  • Samra, Z., Kaufmann, L., Zeharia, A., Ashkenazi, S., Amir, J., Bahar, J., Reischl, U., Naumann, L. (1999). Optimal Detection and Identification of Mycobacterium haemophilum in Specimens from Pediatric Patients with Cervical Lymphadenopathy. J. Clin. Microbiol. 37: 832-834 [Abstract] [Full Text]  
  • Tønjum, T., Welty, D. B., Jantzen, E., Small, P. L. (1998). Differentiation of Mycobacterium ulcerans, M. marinum, and M. haemophilum: Mapping of Their Relationships to M. tuberculosis by Fatty Acid Profile Analysis, DNA-DNA Hybridization, and 16S rRNA Gene Sequence Analysis. J. Clin. Microbiol. 36: 918-925 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»