This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Domachowske, J. B. Search for Related Content PubMed PubMed Citation Articles by Domachowske, J. B.

 Previous Article  |  Next Article 

Clinical Microbiology Reviews, 10 1996, 448-468, Vol 9, No. 4
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Pediatric human immunodeficiency virus infection

JB Domachowske
Pediatric Infectious Disease, State University of New York Health Science Center, Syracuse 13210, USA. jdomach@helix.nih.gov

In the past decade, an increase in pediatric human immunodeficiency virus (HIV) infection has had a substantial impact on childhood morbidity and mortality worldwide. The vertical transmission of HIV from mother to infant accounts for the vast majority of these cases. Identification of HIV-infected pregnant women needs to be impoved so that appropriate therapy can be initiated for both mothers and infants. While recent data demonstrate a dramatic decrease in HIV transmission from a subset of women treated with zidovudine during pregnancy, further efforts at reducing transmission are desperately needed. This review focuses on vertically transmitted HIV infection in children, its epidemiology, diagnostic criteria, natural history, and clinical manifestations including infectious and noninfectious complications. An overview of the complex medical management of these children ensues, including the use of antiretroviral therapy. Opportunistic infection prophylaxis is reviewed, along with the important role of other supportive therapies.

This article has been cited by other articles:

• Langston, C., Cooper, E. R., Goldfarb, J., Easley, K. A., Husak, S., Sunkle, S., Starc, T. J., Colin, A. A., for the P2C2 HIV Study Group, (2001). Human Immunodeficiency Virus-Related Mortality in Infants and Children: Data From the Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV (P2C2) Study. Pediatrics 107: 328-338 [Abstract] [Full Text]  
• Boriskin, Y. S, Sharland, M., Dalton, R., duMont, G., Booth, J. C (1999). Viral loads in dual infection with HIV-1 and cytomegalovirus. Arch. Dis. Child. 80: 132-136 [Abstract] [Full Text]