| Authors |
Reference |
Patients |
Drug(s) |
M. pneumoniae infections
|
| No. of cases |
Detection method(s) |
Outcome and/or comment |
|
| Cassell et al. |
63 |
Adults |
Clarithromycin (14 days) vs erythromycin (14 days) |
15 |
Culture, serology |
Clinical cure was achieved in 4 of 4 (100%) and 3 of 3 (100%) subjects receiving clarithromycin or erythromycin, respectively |
| Block et al. |
47 |
Children |
Clarithromycin (10 days) vs erythromycin (10 days) |
69 |
Culture, PCR, serology |
Mycoplasma eradication was achieved in 9 of 9 (100%) culture-positive evaluable subjects who received clarithromycin vs 4 of 4 (100%) who received erythromycin; eradication rates based on PCR alone were 19 of 22 (86%) vs 24 of 26 (92%) for clarithromycin and erythromycin, respectively (however, significance of a positive PCR assay after treatment is unknown) |
| Wubbel et al. |
446 |
Children |
Azithromycin (5 days) vs erythromycin (10 days) or amoxicillin-clavulanate (10 days) |
12 |
Culture, PCR, serology |
All subjects with mycoplasma infection were classified as having clinical cure after treatment with any agent; however, 1 subject in the azithromycin group had a positive follow-up culture and 1 had a positive PCR |
| Harris et al. |
180 |
Children |
Azithromycin (5 days) vs erythromycin (10 days) or amoxicillin-clavulanate (10 days) |
124 |
Culture, PCR, serology |
Mycoplasma eradication was achieved in 14 of 14 (100%) culture-positive evaluable subjects who received azithromycin vs 4 of 6 (67%) with erythromycin and 0 of 1 with amoxicillin-clavulanate |
| Schonwald et al. |
368 |
Adults |
Azithromycin (3 vs 5 days) |
43 |
Serology |
A 1.5-g total dose of azithromycin was equally effective when administered as a 3- or a 5-day regimen and resulted in clinical cure for all mycoplasmal infections that were encountered |
| Schonwald et al. |
367 |
Adults |
Azithromycin (single dose vs 3 days) |
24 |
Serology |
A single 1.5-g dose of azithromycin was equally effective as a 3-day regimen for treatment of mycoplasmal infection |
| Schonwald et al. |
366 |
Adults |
Azithromycin (5 days) vs erythromycin (10 days) |
55 |
Serology |
Therapeutic success was achieved for all subjects with mycoplasma infection who received either drug |
| Kaku et al. |
216 |
Adults |
Roxithromycin |
13 |
Culture, serology |
Clinical efficacy was documented in 12 of 13 (93%) cases; a bacteriological effect was achieved in 4 of 6 (67%) cases |
| Patel et al. |
322 |
Adults |
Moxifloxacin (10 days) |
29 |
Culture, serology |
A bacteriological response occurred in 27 of 29 (93%) subjects with mycoplasmal infection |
| Finch et al. |
140 |
Adults |
Moxifloxacin (7-14 days) vs amoxicillin-clavulanate with or without clarithromycin (7-14 days) |
30 |
Serology |
Clinical success was documented 21-28 days after the end of treatment in 12 of 13 (93%) subjects who received moxifloxacin and in 16 of 17 (94%) who received the comparator agents |
| Plouffe et al. |
326 |
Adults |
Ofloxacin vs standard treatments with a variety of agents for different durations |
38 |
Serology |
Clinical improvement or cure occurred in 13 of 14 (88%) subjects who were serologically positive for mycoplasma and in 20 of 22 (91%) who received various other treatments |
| File et al. |
138 |
Adults |
Gemifloxacin (7 days) vs trovafloxacin (7 days) |
88 |
Culture, serology |
Clinical success for mycoplasmal infections was documented in 41 of 44 (94%) subjects who received gemifloxacin and in 38 of 40 (95%) who received trovafloxacin |
| File et al. |
139 |
Adults |
Levofloxacin (7-14 days) vs ceftriaxone (7-14 days) or cefuroxime (7-14 days) |
41 |
Serology |
Clinical improvement or cure was documented in 19 of 19 (100%) subjects treated with levofloxacin and in 22 of 22 (100%) who received either ceftriaxone or cefuroxime; the apparent response to cephalosporins may represent self-limited disease or the presence of an undiagnosed copathogen |
| Carbon et al. |
57 |
Adults |
Telithromycin (7-10 days) |
8 |
Serology |
All eight patients with mycoplasmal infection had clinical cure |
| Pullman et al. |
336 |
Adults |
Telithromycin, trovafloxacin |
93 |
Serology, culture, PCR |
Clinical cure was documented in 4 of 4 subjects with mycoplasmal infection who received telithromycin and in 5 of 5 who received trovafloxacin |
