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Clinical Microbiology Reviews, July 1998, p. 497-513, Vol. 11, No. 3
0893-8512/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
Epidemiology of Group B Streptococcal Disease in
the United States: Shifting Paradigms
Anne
Schuchat*
Respiratory Diseases Branch, Division of Bacterial and
Mycotic Diseases, National Center for Infectious Diseases, Centers
for Disease Control and Prevention, Atlanta, Georgia 30333
Since its emergence 25 years ago, group B streptococcus has become recognized as a cause of serious illness in newborns, pregnant women, and adults with chronic medical conditions. Heavy colonization of the genital tract with group B streptococcus also increases the risk that a woman will deliver a preterm low-birthweight infant. Early-onset infections (occurring at <7 days of age) are associated with much lower fatality than when they were first described, and their incidence is finally decreasing as the use of preventive antibiotics during childbirth increases among women at risk. New serotypes of group B streptococcus have emerged as important pathogens in adults and newborns. Clinical and laboratory practices
in obstetrics, pediatrics, and clinical microbiology
have an impact on disease and/or its prevention, and protocols established at the institutional level appear to be critical tools for the reduction of perinatal disease due to group B streptococcus. Since intrapartum antibiotics will prevent at best only a portion of the full burden of group B streptococcal disease, critical developments in vaccine evaluation, including study of polysaccharide-protein conjugate vaccines, offer the potential for enhanced prevention in the relatively near future.
*
Mailing address: Respiratory Diseases Branch, Division
of Bacterial and Mycotic Diseases, National Center for Infectious
Diseases, Mailstop C-23, Centers for Disease Control and Prevention,
Atlanta, GA 30333. Phone: (404) 639-2215. Fax: (404) 639-3970. E-mail: ACS1{at}CDC.GOV.
Clinical Microbiology Reviews, July 1998, p. 497-513, Vol. 11, No. 3
0893-8512/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
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