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Clinical Microbiology Reviews, April 2004, p. 255-267, Vol. 17, No. 2
0893-8512/04/$08.00+0     DOI: 10.1128/CMR.17.2.255-267.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Candida Infections of Medical Devices

Erna M. Kojic and Rabih O. Darouiche*

Medical Service, Infectious Disease Section, Veterans Affairs Medical Center, and Center for Prostheses Infection, Baylor College of Medicine, Houston, Texas

The number of indwelling medical devices is escalating, and an increasing proportion of device-related infections are being caused by Candida spp. Candida spp. produce biofilms on synthetic materials, which facilitates adhesion of the organisms to devices and renders them relatively refractory to medical therapy. Management of device-related Candida infections can be challenging. Removal of the infected device is generally needed to establish cure of Candida infections of medical devices. However, since the pathogenesis of Candida bloodstream infection is complicated, more studies are necessary to determine the role of catheter exchange in patients with both gastrointestinal tract mucositis and indwelling catheters. The medical and economic impact of these infections is enormous.

* Corresponding author. Mailing address: Center for Prostheses Infection, Baylor College of Medicine, 1333 Moursund Ave., Suite A221, Houston, TX 77030. Phone: (713) 799-5088. Fax: (713) 799-5058. E-mail: rdarouiche{at}aol.com.

Clinical Microbiology Reviews, April 2004, p. 255-267, Vol. 17, No. 2
0893-8512/04/$08.00+0     DOI: 10.1128/CMR.17.2.255-267.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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