This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lindahl, G. Articles by Areschoug, T. Search for Related Content PubMed PubMed Citation Articles by Lindahl, G. Articles by Areschoug, T.

 Previous Article  |  Next Article 

Clinical Microbiology Reviews, January 2005, p. 102-127, Vol. 18, No. 1
0893-8512/05/$08.00+0     doi:10.1128/CMR.18.1.102-127.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Surface Proteins of Streptococcus agalactiae and Related Proteins in Other Bacterial Pathogens

Department of Medical Microbiology, Dermatology and Infection, Lund University, Sölvegatan 23, Lund, Sweden

Streptococcus agalactiae (group B Streptococcus) is the major cause of invasive bacterial disease, including meningitis, in the neonatal period. Although prophylactic measures have contributed to a substantial reduction in the number of infections, development of a vaccine remains an important goal. While much work in this field has focused on the S. agalactiae polysaccharide capsule, which is an important virulence factor that elicits protective immunity, surface proteins have received increasing attention as potential virulence factors and vaccine components. Here, we summarize current knowledge about S. agalactiae surface proteins, with emphasis on proteins that have been characterized immunochemically and/or elicit protective immunity in animal models. These surface proteins have been implicated in interactions with human epithelial cells, binding to extracellular matrix components, and/or evasion of host immunity. Of note, several S. agalactiae surface proteins are related to surface proteins identified in other bacterial pathogens, emphasizing the general interest of the S. agalactiae proteins. Because some S. agalactiae surface proteins elicit protective immunity, they hold promise as components in a vaccine based only on proteins or as carriers in polysaccharide conjugate vaccines.

This article has been cited by other articles:

• Kong, F., Lambertsen, L. M., Slotved, H.-C., Ko, D., Wang, H., Gilbert, G. L. (2008). Use of Phenotypic and Molecular Serotype Identification Methods To Characterize Previously Nonserotypeable Group B Streptococci. J. Clin. Microbiol. 46: 2745-2750 [Abstract] [Full Text]  
• Yang, H.-H., Mascuch, S. J., Madoff, L. C., Paoletti, L. C. (2008). Recombinant Group B Streptococcus Alpha-Like Protein 3 Is an Effective Immunogen and Carrier Protein. CVI 15: 1035-1041 [Abstract] [Full Text]  
• Sutcliffe, I. C., Black, G. W., Harrington, D. J. (2008). Bioinformatic insights into the biosynthesis of the Group B carbohydrate in Streptococcus agalactiae. Microbiology 154: 1354-1363 [Abstract] [Full Text]  
• Berlanda Scorza, F., Doro, F., Rodriguez-Ortega, M. J., Stella, M., Liberatori, S., Taddei, A. R., Serino, L., Gomes Moriel, D., Nesta, B., Fontana, M. R., Spagnuolo, A., Pizza, M., Norais, N., Grandi, G. (2008). Proteomics Characterization of Outer Membrane Vesicles from the Extraintestinal Pathogenic Escherichia coli {Delta}tolR IHE3034 Mutant. Mol. Cell. Proteomics 7: 473-485 [Abstract] [Full Text]  
• Bolduc, G. R., Madoff, L. C. (2007). The group B streptococcal alpha C protein binds {alpha}1 1-integrin through a novel KTD motif that promotes internalization of GBS within human epithelial cells. Microbiology 153: 4039-4049 [Abstract] [Full Text]  
• Samen, U., Eikmanns, B. J., Reinscheid, D. J., Borges, F. (2007). The Surface Protein Srr-1 of Streptococcus agalactiae Binds Human Keratin 4 and Promotes Adherence to Epithelial HEp-2 Cells. Infect. Immun. 75: 5405-5414 [Abstract] [Full Text]  
• Gherardi, G., Imperi, M., Baldassarri, L., Pataracchia, M., Alfarone, G., Recchia, S., Orefici, G., Dicuonzo, G., Creti, R. (2007). Molecular Epidemiology and Distribution of Serotypes, Surface Proteins, and Antibiotic Resistance among Group B Streptococci in Italy. J. Clin. Microbiol. 45: 2909-2916 [Abstract] [Full Text]  
• Yang, H.-H., Madoff, L. C., Guttormsen, H.-K., Liu, Y.-D., Paoletti, L. C. (2007). Recombinant Group B Streptococcus Beta C Protein and a Variant with the Deletion of Its Immunoglobulin A-Binding Site Are Protective Mouse Maternal Vaccines and Effective Carriers in Conjugate Vaccines. Infect. Immun. 75: 3455-3461 [Abstract] [Full Text]  
• Bierne, H., Cossart, P. (2007). Listeria monocytogenes Surface Proteins: from Genome Predictions to Function. Microbiol. Mol. Biol. Rev. 71: 377-397 [Abstract] [Full Text]  
• Ho, Y.-R., Li, C.-M., Su, H.-P., Wu, J.-H., Tseng, Y.-C., Lin, Y.-J., Wu, J.-J. (2007). Variation in the Number of Tandem Repeats and Profile of Surface Protein Genes among Invasive Group B Streptococci Correlates with Patient Age. J. Clin. Microbiol. 45: 1634-1636 [Abstract] [Full Text]  
• Rosenau, A., Martins, K., Amor, S., Gannier, F., Lanotte, P., van der Mee-Marquet, N., Mereghetti, L., Quentin, R. (2007). Evaluation of the Ability of Streptococcus agalactiae Strains Isolated from Genital and Neonatal Specimens To Bind to Human Fibrinogen and Correlation with Characteristics of the fbsA and fbsB Genes. Infect. Immun. 75: 1310-1317 [Abstract] [Full Text]  
• Larsson, C, Lindroth, M, Nordin, P, Stalhammar-Carlemalm, M, Lindahl, G, Krantz, I (2006). Association between low concentrations of antibodies to protein {alpha} and Rib and invasive neonatal group B streptococcal infection.. Arch. Dis. Child. Fetal Neonatal Ed. 91: F403-F408 [Abstract] [Full Text]  
• Zeng, X., Kong, F., Morgan, J., Gilbert, G. L. (2006). Evaluation of a Multiplex PCR-Based Reverse Line Blot-Hybridization Assay for Identification of Serotype and Surface Protein Antigens of Streptococcus agalactiae.. J. Clin. Microbiol. 44: 3822-3825 [Abstract] [Full Text]  
• Ramaswamy, S. V., Ferrieri, P., Flores, A. E., Paoletti, L. C. (2006). Molecular characterization of nontypeable group B streptococcus.. J. Clin. Microbiol. 44: 2398-2403 [Abstract] [Full Text]  
• Ramaswamy, S. V., Ferrieri, P., Madoff, L. C., Flores, A. E., Kumar, N., Tettelin, H., Paoletti, L. C. (2006). Identification of novel cps locus polymorphisms in nontypable group B Streptococcus. J Med Microbiol 55: 775-783 [Abstract] [Full Text]  
• Lin, F.-Y. C., Whiting, A., Adderson, E., Takahashi, S., Dunn, D. M., Weiss, R., Azimi, P. H., Philips, J. B. III, Weisman, L. E., Regan, J., Clark, P., Rhoads, G. G., Frasch, C. E., Troendle, J., Moyer, P., Bohnsack, J. F. (2006). Phylogenetic Lineages of Invasive and Colonizing Strains of Serotype III Group B Streptococci from Neonates: a Multicenter Prospective Study. J. Clin. Microbiol. 44: 1257-1261 [Abstract] [Full Text]  
• Seifert, K. N., Adderson, E. E., Whiting, A. A., Bohnsack, J. F., Crowley, P. J., Brady, L. J. (2006). A unique serine-rich repeat protein (Srr-2) and novel surface antigen ({varepsilon}) associated with a virulent lineage of serotype III Streptococcus agalactiae.. Microbiology 152: 1029-1040 [Abstract] [Full Text]  
• Seepersaud, R., Needham, R. H. V., Kim, C. S., Jones, A. L. (2006). Abundance of the {delta} Subunit of RNA Polymerase Is Linked to the Virulence of Streptococcus agalactiae. J. Bacteriol. 188: 2096-2105 [Abstract] [Full Text]  
• Nagano, N., Nagano, Y., Nakano, R., Okamoto, R., Inoue, M. (2006). Genetic diversity of the C protein beta-antigen gene and its upstream regions within clonally related groups of type Ia and Ib group B streptococci.. Microbiology 152: 771-778 [Abstract] [Full Text]  
• Waldemarsson, J., Areschoug, T., Lindahl, G., Johnsson, E. (2006). The Streptococcal Blr and Slr Proteins Define a Family of Surface Proteins with Leucine-Rich Repeats: Camouflaging by Other Surface Structures. J. Bacteriol. 188: 378-388 [Abstract] [Full Text]