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Clinical Microbiology Reviews, October 2005, p. 719-756, Vol. 18, No. 4
0893-8512/05/$08.00+0     doi:10.1128/CMR.18.4.719-756.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Tick-Borne Rickettsioses around the World: Emerging Diseases Challenging Old Concepts

Philippe Parola,1 Christopher D. Paddock,2 and Didier Raoult1*

Unité des Rickettsies, CNRS UMR 6020, IFR 48, Université de la Méditerranée, Faculté de Médecine, 13385 Marseille Cedex 5, France,1 Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Mailstop G-32, 1600 Clifton Road, Atlanta, Georgia2

During most of the 20th century, the epidemiology of tick-borne rickettsioses could be summarized as the occurrence of a single pathogenic rickettsia on each continent. An element of this paradigm suggested that the many other characterized and noncharacterized rickettsiae isolated from ticks were not pathogenic to humans. In this context, it was considered that relatively few tick-borne rickettsiae caused human disease. This concept was modified extensively from 1984 through 2005 by the identification of at least 11 additional rickettsial species or subspecies that cause tick-borne rickettsioses around the world. Of these agents, seven were initially isolated from ticks, often years or decades before a definitive association with human disease was established. We present here the tick-borne rickettsioses described through 2005 and focus on the epidemiological circumstances that have played a role in the emergence of the newly recognized diseases.

* Corresponding author. Mailing address: Unité des Rickettsies, CNRS UMR 6020, IFR 48, Université de la Méditerranée, Faculté de Médecine, 27 Bd. Jean Moulin, 13385 Marseille Cedex 5, France. Phone: (33) 4 91 32 43 75. Fax: (33) 4 91 32 03 90. E-mail: Didier.Raoult{at}medecine.univ-mrs.fr.

Clinical Microbiology Reviews, October 2005, p. 719-756, Vol. 18, No. 4
0893-8512/05/$08.00+0     doi:10.1128/CMR.18.4.719-756.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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