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Clinical Microbiology Reviews, July 2006, p. 546-557, Vol. 19, No. 3
0893-8512/06/$08.00+0     doi:10.1128/CMR.00014-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Epidemiology of Human Metapneumovirus

Jeffrey S. Kahn*

Department of Pediatrics, Division of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut 06520

Since the discovery of human metapneumovirus (hMPV) in 2001, the virus has been identified worldwide. hMPV is a common respiratory pathogen, particularly in infants and young children. The virus is associated with both upper and lower respiratory tract infections and may be a trigger for asthma. At least two major genotypes of hMPV circulate during community outbreaks. Whether these genotypes represent distinct serotypes remains controversial. The major challenges faced by the medical and scientific communities are the understanding of the pathogenesis of hMPV disease and the development of a safe and effective vaccine to protect against infection and disease caused by this newly recognized respiratory virus.

* Mailing address: Department of Pediatrics, Division of Infectious Diseases, Yale University School of Medicine, P.O. Box 208064, New Haven, CT 06520-8064. Phone: (203) 785-6778. Fax: (203) 785-6961. E-mail: jeffrey.kahn{at}yale.edu.

Clinical Microbiology Reviews, July 2006, p. 546-557, Vol. 19, No. 3
0893-8512/06/$08.00+0     doi:10.1128/CMR.00014-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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