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Clinical Microbiology Reviews, October 2006, p. 597-613, Vol. 19, No. 4
0893-8512/06/$08.00+0     doi:10.1128/CMR.00006-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Helicobacter pylori Persistence: an Overview of Interactions between H. pylori and Host Immune Defenses

Holly M. Scott Algood1 and Timothy L. Cover1,2,3*

Departments of Medicine,1 Microbiology and Immunology, Vanderbilt University School of Medicine,2 Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee3

Helicobacter pylori is a gram-negative bacterium that persistently colonizes more than half of the global human population. In order to successfully colonize the human stomach, H. pylori must initially overcome multiple innate host defenses. Remarkably, H. pylori can persistently colonize the stomach for decades or an entire lifetime despite development of an acquired immune response. This review focuses on the immune response to H. pylori and the mechanisms by which H. pylori resists immune clearance. Three main sections of the review are devoted to (i) analysis of the immune response to H. pylori in humans, (ii) analysis of interactions of H. pylori with host immune defenses in animal models, and (iii) interactions of H. pylori with immune cells in vitro. The topics addressed in this review are important for understanding how H. pylori resists immune clearance and also are relevant for understanding the pathogenesis of diseases caused by H. pylori (peptic ulcer disease, gastric adenocarcinoma, and gastric lymphoma).

* Corresponding author. Mailing address: Division of Infectious Diseases, A2200 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232. Phone: (615) 322-2035. Fax: (615) 343-6160. E-mail: timothy.L.cover{at}vanderbilt.edu.

Clinical Microbiology Reviews, October 2006, p. 597-613, Vol. 19, No. 4
0893-8512/06/$08.00+0     doi:10.1128/CMR.00006-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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Copyright © 2006 by the American Society for Microbiology. All rights reserved.