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Clinical Microbiology Reviews, January 2007, p. 13-22, Vol. 20, No. 1
0893-8512/07/$08.00+0 doi:10.1128/CMR.00016-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Rat Bite Fever and Streptobacillus moniliformis
Sean P. Elliott*
Department of Pediatrics and Steele Children's Research Center, University of Arizona Health Sciences Center, Tucson, Arizona
Rat bite fever, caused by Streptobacillus moniliformis, is a systemic illness classically characterized by fever, rigors, and polyarthralgias. If left untreated, it carries a mortality rate of 10%. Unfortunately, its nonspecific initial presentation combined with difficulties in culturing its causative organism produces a significant risk of delay or failure in diagnosis. The increasing popularity of rats and other rodents as pets, together with the risk of invasive or fatal disease, demands increased attention to rat bite fever as a potential diagnosis. The clinical and biological features of rat bite fever and Streptobacillus moniliformis are reviewed, providing some distinguishing features to assist the clinician and microbiologist in diagnosis.
* Corresponding author. Mailing address: Department of Pediatrics, University of Arizona Health Sciences Center, 1501 N. Campbell Ave., Tucson, AZ 85724-5073. Phone: (520) 626-6507. Fax: (520) 626-5652. E-mail:
selliott{at}peds.arizona.edu.
Clinical Microbiology Reviews, January 2007, p. 13-22, Vol. 20, No. 1
0893-8512/07/$08.00+0 doi:10.1128/CMR.00016-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.
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