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Clinical Microbiology Reviews, April 2007, p. 280-322, Vol. 20, No. 2
0893-8512/07/$08.00+0     doi:10.1128/CMR.00033-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Helicobacter pylori Detection and Antimicrobial Susceptibility Testing

Francis Mégraud* and Philippe Lehours

INSERM U853, F33076 Bordeaux, France, and Université Victor Segalen Bordeaux 2, Laboratoire de Bactériologie, F33076 Bordeaux, France

The discovery of Helicobacter pylori in 1982 was the starting point of a revolution concerning the concepts and management of gastroduodenal diseases. It is now well accepted that the most common stomach disease, peptic ulcer disease, is an infectious disease, and all consensus conferences agree that the causative agent, H. pylori, must be treated with antibiotics. Furthermore, the concept emerged that this bacterium could be the trigger of various malignant diseases of the stomach, and it is now a model for chronic bacterial infections causing cancer. Most of the many different techniques involved in diagnosis of H. pylori infection are performed in clinical microbiology laboratories. The aim of this article is to review the current status of these methods and their application, highlighting the important progress which has been made in the past decade. Both invasive and noninvasive techniques will be reviewed.

* Corresponding author. Mailing address: Laboratoire de Bactériologie, Hôpital Pellegrin, Place Amélie Raba-Léon, 33076 Bordeaux cedex, France. Phone: 33 5 56 79 59 10. Fax: 33 5 56 79 60 18. E-mail: francis.megraud{at}chu-bordeaux.fr

Clinical Microbiology Reviews, April 2007, p. 280-322, Vol. 20, No. 2
0893-8512/07/$08.00+0     doi:10.1128/CMR.00033-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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