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Clinical Microbiology Reviews, July 2007, p. 489-510, Vol. 20, No. 3
0893-8512/07/$08.00+0     doi:10.1128/CMR.00005-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Current Status of Veterinary Vaccines

Els N. T. Meeusen,1* John Walker,2 Andrew Peters,3 Paul-Pierre Pastoret,4 and Gregers Jungersen5

Animal Biotechnology Research Laboratories, Department of Physiology, Monash University, Victoria 3800, Australia,1 VMRD Pfizer Australia, 52 Poplar Rd., Parkville, Victoria 3052, Australia,2 University of Edinburgh, Royal (Dick) School of Veterinary Studies, Easter Bush, Roslin, Midlothian EH25 9RG, United Kingdom,3 Publications Department, World Organisation for Animal Health, 12 rue de Prony, 75017 Paris, France,4 National Veterinary Institute, Technical University of Denmark, Bülowsvej 27, 1790 Copenhagen, Denmark5

The major goals of veterinary vaccines are to improve the health and welfare of companion animals, increase production of livestock in a cost-effective manner, and prevent animal-to-human transmission from both domestic animals and wildlife. These diverse aims have led to different approaches to the development of veterinary vaccines from crude but effective whole-pathogen preparations to molecularly defined subunit vaccines, genetically engineered organisms or chimeras, vectored antigen formulations, and naked DNA injections. The final successful outcome of vaccine research and development is the generation of a product that will be available in the marketplace or that will be used in the field to achieve desired outcomes. As detailed in this review, successful veterinary vaccines have been produced against viral, bacterial, protozoal, and multicellular pathogens, which in many ways have led the field in the application and adaptation of novel technologies. These veterinary vaccines have had, and continue to have, a major impact not only on animal health and production but also on human health through increasing safe food supplies and preventing animal-to-human transmission of infectious diseases. The continued interaction between animals and human researchers and health professionals will be of major importance for adapting new technologies, providing animal models of disease, and confronting new and emerging infectious diseases.

* Corresponding author. Mailing address: Department of Physiology, Building 13f, Monash University, Clayton, Victoria 3800, Australia. Phone: 61 3 99052513. Fax: 61 3 99052547. E-mail: els.meeusen{at}med.monash.edu.au

Clinical Microbiology Reviews, July 2007, p. 489-510, Vol. 20, No. 3
0893-8512/07/$08.00+0     doi:10.1128/CMR.00005-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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