beta-Lactamases in laboratory and clinical resistance

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Clinical Microbiology Reviews, Oct 1995, 557-584, Vol 8, No. 4
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

beta-Lactamases in laboratory and clinical resistance

DM Livermore
Department of Medical Microbiology, London Hospital Medical College, United Kingdom.

beta-Lactamases are the commonest single cause of bacterial resistance to beta-lactam antibiotics. Numerous chromosomal and plasmid-mediated types are known and may be classified by their sequences or phenotypic properties. The ability of a beta-lactamase to cause resistance varies with its activity, quantity, and cellular location and, for gram- negative organisms, the permeability of the producer strain. beta- Lactamases sometimes cause obvious resistance to substrate drugs in routine tests; often, however, these enzymes reduce susceptibility without causing resistance at current, pharmacologically chosen breakpoints. This review considers the ability of the prevalent beta- lactamases to cause resistance to widely used beta-lactams, whether resistance is accurately reflected in routine tests, and the extent to which the antibiogram for an organism can be used to predict the type of beta-lactamase that it produces.

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Jamieson, C. E., Lambert, P. A., Simpson, I. N. (2003). In Vitro Activities of Novel Oxapenems, Alone and in Combination with Ceftazidime, against Gram-Positive and Gram-Negative Organisms. Antimicrob. Agents Chemother. 47: 2615-2618 [Abstract] [Full Text]
Beauchef-Havard, A., Arlet, G., Gautier, V., Labia, R., Grimont, P., Philippon, A. (2003). Molecular and Biochemical Characterization of a Novel Class A {beta}-Lactamase (HER-1) from Escherichia hermannii. Antimicrob. Agents Chemother. 47: 2669-2673 [Abstract] [Full Text]
Cheng, H.-P., Siu, L. K., Chang, F.-Y. (2003). Extended-Spectrum Cephalosporin Compared to Cefazolin for Treatment of Klebsiella pneumoniae-Caused Liver Abscess. Antimicrob. Agents Chemother. 47: 2088-2092 [Abstract] [Full Text]
Siu, L. K., Lu, P.-L., Chen, J.-Y., Lin, F. M., Chang, S.-C. (2003). High-Level Expression of AmpC {beta}-Lactamase Due to Insertion of Nucleotides between -10 and -35 Promoter Sequences in Escherichia coli Clinical Isolates: Cases Not Responsive to Extended-Spectrum-Cephalosporin Treatment. Antimicrob. Agents Chemother. 47: 2138-2144 [Abstract] [Full Text]
Kwon, D. H., Dore, M. P., Kim, J. J., Kato, M., Lee, M., Wu, J. Y., Graham, D. Y. (2003). High-Level {beta}-Lactam Resistance Associated with Acquired Multidrug Resistance in Helicobacter pylori. Antimicrob. Agents Chemother. 47: 2169-2178 [Abstract] [Full Text]
Tenover, F. C., Raney, P. M., Williams, P. P., Rasheed, J. K., Biddle, J. W., Oliver, A., Fridkin, S. K., Jevitt, L., McGowan, J. E. Jr. (2003). Evaluation of the NCCLS Extended-Spectrum {beta}-Lactamase Confirmation Methods for Escherichia coli with Isolates Collected during Project ICARE. J. Clin. Microbiol. 41: 3142-3146 [Abstract] [Full Text]
Karlowsky, J. A., Weaver, M. K., Thornsberry, C., Dowzicky, M. J., Jones, M. E., Sahm, D. F. (2003). Comparison of Four Antimicrobial Susceptibility Testing Methods To Determine the In Vitro Activities of Piperacillin and Piperacillin-Tazobactam against Clinical Isolates of Enterobacteriaceae and Pseudomonas aeruginosa. J. Clin. Microbiol. 41: 3339-3343 [Abstract] [Full Text]
Theron, M. M., Janse van Rensburg, M. N., Chalkley, L. J. (2003). Penicillin-binding proteins involved in high-level piperacillin resistance in Veillonella spp.. J Antimicrob Chemother 52: 120-122 [Abstract] [Full Text]
Lee, S. H., Kim, J. Y., Shin, S. H., An, Y. J., Choi, Y. W., Jung, Y. C., Jung, H. I., Sohn, E. S., Jeong, S. H., Lee, K. J. (2003). Dissemination of SHV-12 and Characterization of New AmpC-Type Beta-Lactamase Genes among Clinical Isolates of Enterobacter Species in Korea. J. Clin. Microbiol. 41: 2477-2482 [Abstract] [Full Text]
Mammeri, H., Poirel, L., Mangeney, N., Nordmann, P. (2003). Chromosomal Integration of a Cephalosporinase Gene from Acinetobacter baumannii into Oligella urethralis as a Source of Acquired Resistance to {beta}-Lactams. Antimicrob. Agents Chemother. 47: 1536-1542 [Abstract] [Full Text]
Jamieson, C. E., Lambert, P. A., Simpson, I. N. (2003). In Vitro and In Vivo Activities of AM-112, a Novel Oxapenem. Antimicrob. Agents Chemother. 47: 1652-1657 [Abstract] [Full Text]
Karlowsky, J. A., Jones, M. E., Thornsberry, C., Friedland, I. R., Sahm, D. F. (2003). Trends in Antimicrobial Susceptibilities among Enterobacteriaceae Isolated from Hospitalized Patients in the United States from 1998 to 2001. Antimicrob. Agents Chemother. 47: 1672-1680 [Abstract] [Full Text]
Barry, J., Brown, A., Ensor, V., Lakhani, U., Petts, D., Warren, C., Winstanley, T. (2003). Comparative evaluation of the VITEK 2 Advanced Expert System (AES) in five UK hospitals. J Antimicrob Chemother 51: 1191-1202 [Abstract] [Full Text]
Sanguinetti, M., Posteraro, B., Spanu, T., Ciccaglione, D., Romano, L., Fiori, B., Nicoletti, G., Zanetti, S., Fadda, G. (2003). Characterization of Clinical Isolates of Enterobacteriaceae from Italy by the BD Phoenix Extended-Spectrum {beta}-Lactamase Detection Method. J. Clin. Microbiol. 41: 1463-1468 [Abstract] [Full Text]
Stock, I., Burak, S., Sherwood, K. J., Gruger, T., Wiedemann, B. (2003). Natural antimicrobial susceptibilities of strains of 'unusual' Serratia species: S. ficaria, S. fonticola, S. odorifera, S. plymuthica and S. rubidaea. J Antimicrob Chemother 51: 865-885 [Abstract] [Full Text]
Fahr, A.-M., Eigner, U., Armbrust, M., Caganic, A., Dettori, G., Chezzi, C., Bertoncini, L., Benecchi, M., Menozzi, M. G. (2003). Two-Center Collaborative Evaluation of the Performance of the BD Phoenix Automated Microbiology System for Identification and Antimicrobial Susceptibility Testing of Enterococcus spp. and Staphylococcus spp.. J. Clin. Microbiol. 41: 1135-1142 [Abstract] [Full Text]
Sun, T., Nukaga, M., Mayama, K., Braswell, E. H., Knox, J. R. (2003). Comparison of {beta}-lactamases of classes A and D: 1.5-A crystallographic structure of the class D OXA-1 oxacillinase. Protein Sci. 12: 82-91 [Abstract] [Full Text]

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