DOI: 10.1128/CMR.12.1.9
Article Figures & Data
Figures
- Fig. 1.
Effect of allergy on RV16-induced changes in lower-airway histamine responsiveness. Subjects were grouped according to the presence or absence of allergy, and histamine PD20was plotted precold (pre), and 2 days following RV16 inoculation (cold). Heavy horizontal lines represent group mean data. n.s., not significant. Reprinted from reference 50 with permission of the publisher.
- Fig. 2.
Potential mechanisms for lower-airway dysfunction caused by RV infections.
- Fig. 3.
Mechanisms of RV-induced exacerbations of asthma, and therapeutic implications. See the text for details. Abbreviations: sICAM-1, soluble ICAM-1; PKR, double-stranded-RNA-activated protein kinase; CS, corticosteroids.
Tables
- Table 1.
RV-induced immune responses and association with clinical observationsa
Immune response Locationb Associated clinical observationsb Reference(s) Upper airway ↑ Kinins NS ↑ Symptom scores 98 ↑ Neutrophils or myeloperoxidase NS ↑ Symptom scores 91, 98, 125 ↓ Lymphocytes Blood ↑ Symptom scores 90 ↑ Lymphocytes NS ↑ Symptom scores 91 ↑ RV-specific T-cell proliferation Blood ↑ Nasal mucus 75 ↑ Albumin NS ↑ Symptom scores 98 ↑ IL-1 NS ↑ Symptom scores 105 ↑ IL-2 (ex vivo) Blood ↓ Nasal mucus, ↓ duration of viral shedding 75 ↑ IL-6 NS ↑ Symptom scores 139 ↑ IL-8 NS ↑ Symptom scores 58, 130 Lower airway ↑ Eosinophil cationic protein Sputum ↑ Airway responsiveness 57 ↓ Lymphocytes Blood ↑ Airway responsiveness, MFEV1 24, 43 ↑ Neutrophils NS ↑ Airway responsiveness 58 ↑ IL-8 NS ↑ Airway responsiveness 58 ↑ IL-11 NS Wheezing 32
