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Clinical Microbiology Best Practices

A Laboratory Medicine Best Practices Systematic Review and Meta-analysis of Nucleic Acid Amplification Tests (NAATs) and Algorithms Including NAATs for the Diagnosis of Clostridioides (Clostridium) difficile in Adults

Colleen S. Kraft, J. Scott Parrott, Nancy E. Cornish, Matthew L. Rubinstein, Alice S. Weissfeld, Peggy McNult, Irving Nachamkin, Romney M. Humphries, Thomas J. Kirn, Jennifer Dien Bard, Joseph D. Lutgring, Jonathan C. Gullett, Cassiana E. Bittencourt, Susan Benson, April M. Bobenchik, Robert L. Sautter, Vickie Baselski, Michel C. Atlas, Elizabeth M. Marlowe, Nancy S. Miller, Monika Fischer, Sandra S. Richter, Peter Gilligan, James W. Snyder
Colleen S. Kraft
aEmory University School of Medicine, Atlanta, Georgia, USA
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J. Scott Parrott
bDepartment of Interdisciplinary Studies, School of Health Professions, Rutgers University, Newark, New Jersey, USA
cDepartment of Epidemiology, School of Public Health, Rutgers University, Piscataway, New Jersey, USA
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Nancy E. Cornish
dCenters for Disease Control and Prevention, Atlanta, Georgia, USA
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Matthew L. Rubinstein
dCenters for Disease Control and Prevention, Atlanta, Georgia, USA
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Alice S. Weissfeld
eMicrobiology Specialists Incorporated, Houston, Texas, USA
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Peggy McNult
fAmerican Society for Microbiology, Washington, DC, USA
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Irving Nachamkin
gPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Romney M. Humphries
hAccelerate Diagnostics, Tucson, Arizona, USA
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Thomas J. Kirn
bDepartment of Interdisciplinary Studies, School of Health Professions, Rutgers University, Newark, New Jersey, USA
cDepartment of Epidemiology, School of Public Health, Rutgers University, Piscataway, New Jersey, USA
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Jennifer Dien Bard
iChildren’s Hospital Los Angeles, Los Angeles, California, USA
jKeck School of Medicine, University of Southern California, Los Angeles, California, USA
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Joseph D. Lutgring
aEmory University School of Medicine, Atlanta, Georgia, USA
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Jonathan C. Gullett
kKaiser Permanente (Southern California Permanente Medical Group) Regional Reference Laboratories, Greater Los Angeles, Los Angeles, California, USA
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Cassiana E. Bittencourt
lUniversity of California—Irvine, Orange, California, USA
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Susan Benson
mPathWest Laboratory Medicine, Perth, Western Australia, Australia
nUniversity of Western Australia, Perth, Western Australia, Australia
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  • ORCID record for Susan Benson
April M. Bobenchik
oRhode Island Hospital/Lifespan Academic Medical Center, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
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Robert L. Sautter
pRL Sautter Consulting LLC, Lancaster, South Carolina, USA
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Vickie Baselski
qUniversity of Tennessee Health Science Center, Memphis, Tennessee, USA
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Michel C. Atlas
rKornhauser Health Sciences Library, University of Louisville, Louisville, Kentucky, USA
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Elizabeth M. Marlowe
sRoche Molecular Systems, Pleasanton, California, USA
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Nancy S. Miller
tBoston Medical Center, Boston, Massachusetts, USA
uBoston University School of Medicine, Boston, Massachusetts, USA
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Monika Fischer
vIndiana University, Indianapolis, Indiana, USA
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Sandra S. Richter
wCleveland Clinic, Cleveland, Ohio, USA
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Peter Gilligan
xUniversity of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
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James W. Snyder
rKornhauser Health Sciences Library, University of Louisville, Louisville, Kentucky, USA
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DOI: 10.1128/CMR.00032-18
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Article Information

DOI 
https://doi.org/10.1128/CMR.00032-18
PubMed 
31142497

Published By 
American Society for Microbiology Journals
History 
  • Published online May 29, 2019.

Copyright & Usage 
Copyright © 2019 Kraft et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

Author Information

  1. Colleen S. Krafta,
  2. J. Scott Parrottb,c,
  3. Nancy E. Cornishd,
  4. Matthew L. Rubinsteind,
  5. Alice S. Weissfelde,
  6. Peggy McNultf,
  7. Irving Nachamking,
  8. Romney M. Humphriesh,
  9. Thomas J. Kirnb,c,
  10. Jennifer Dien Bardi,j,
  11. Joseph D. Lutgringa,
  12. Jonathan C. Gullettk,
  13. Cassiana E. Bittencourtl,
  14. Susan Bensonm,n,
  15. April M. Bobenchiko,
  16. Robert L. Sautterp,
  17. Vickie Baselskiq,
  18. Michel C. Atlasr,
  19. Elizabeth M. Marlowes,
  20. Nancy S. Millert,u,
  21. Monika Fischerv,
  22. Sandra S. Richterw,
  23. Peter Gilliganx and
  24. James W. Snyderr
  1. aEmory University School of Medicine, Atlanta, Georgia, USA
  2. bDepartment of Interdisciplinary Studies, School of Health Professions, Rutgers University, Newark, New Jersey, USA
  3. cDepartment of Epidemiology, School of Public Health, Rutgers University, Piscataway, New Jersey, USA
  4. dCenters for Disease Control and Prevention, Atlanta, Georgia, USA
  5. eMicrobiology Specialists Incorporated, Houston, Texas, USA
  6. fAmerican Society for Microbiology, Washington, DC, USA
  7. gPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
  8. hAccelerate Diagnostics, Tucson, Arizona, USA
  9. iChildren’s Hospital Los Angeles, Los Angeles, California, USA
  10. jKeck School of Medicine, University of Southern California, Los Angeles, California, USA
  11. kKaiser Permanente (Southern California Permanente Medical Group) Regional Reference Laboratories, Greater Los Angeles, Los Angeles, California, USA
  12. lUniversity of California—Irvine, Orange, California, USA
  13. mPathWest Laboratory Medicine, Perth, Western Australia, Australia
  14. nUniversity of Western Australia, Perth, Western Australia, Australia
  15. oRhode Island Hospital/Lifespan Academic Medical Center, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
  16. pRL Sautter Consulting LLC, Lancaster, South Carolina, USA
  17. qUniversity of Tennessee Health Science Center, Memphis, Tennessee, USA
  18. rKornhauser Health Sciences Library, University of Louisville, Louisville, Kentucky, USA
  19. sRoche Molecular Systems, Pleasanton, California, USA
  20. tBoston Medical Center, Boston, Massachusetts, USA
  21. uBoston University School of Medicine, Boston, Massachusetts, USA
  22. vIndiana University, Indianapolis, Indiana, USA
  23. wCleveland Clinic, Cleveland, Ohio, USA
  24. xUniversity of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
  • Address correspondence to Colleen S. Kraft, colleen.kraft{at}emory.edu, or James W. Snyder, jwsnyd01{at}louisville.edu.
  • Citation Kraft CS, Parrott JS, Cornish NE, Rubinstein ML, Weissfeld AS, McNult P, Nachamkin I, Humphries RM, Kirn TJ, Dien Bard J, Lutgring JD, Gullett JC, Bittencourt CE, Benson S, Bobenchik AM, Sautter RL, Baselski V, Atlas MC, Marlowe EM, Miller NS, Fischer M, Richter SS, Gilligan P, Snyder JW. 2019. A laboratory medicine best practices systematic review and meta-analysis of nucleic acid amplification tests (NAATs) and algorithms including NAATs for the diagnosis of Clostridioides (Clostridium) difficile in adults. Clin Microbiol Rev 32:e00032-18. https://doi.org/10.1128/CMR.00032-18.

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A Laboratory Medicine Best Practices Systematic Review and Meta-analysis of Nucleic Acid Amplification Tests (NAATs) and Algorithms Including NAATs for the Diagnosis of Clostridioides (Clostridium) difficile in Adults
Colleen S. Kraft, J. Scott Parrott, Nancy E. Cornish, Matthew L. Rubinstein, Alice S. Weissfeld, Peggy McNult, Irving Nachamkin, Romney M. Humphries, Thomas J. Kirn, Jennifer Dien Bard, Joseph D. Lutgring, Jonathan C. Gullett, Cassiana E. Bittencourt, Susan Benson, April M. Bobenchik, Robert L. Sautter, Vickie Baselski, Michel C. Atlas, Elizabeth M. Marlowe, Nancy S. Miller, Monika Fischer, Sandra S. Richter, Peter Gilligan, James W. Snyder
Clinical Microbiology Reviews May 2019, 32 (3) e00032-18; DOI: 10.1128/CMR.00032-18

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A Laboratory Medicine Best Practices Systematic Review and Meta-analysis of Nucleic Acid Amplification Tests (NAATs) and Algorithms Including NAATs for the Diagnosis of Clostridioides (Clostridium) difficile in Adults
Colleen S. Kraft, J. Scott Parrott, Nancy E. Cornish, Matthew L. Rubinstein, Alice S. Weissfeld, Peggy McNult, Irving Nachamkin, Romney M. Humphries, Thomas J. Kirn, Jennifer Dien Bard, Joseph D. Lutgring, Jonathan C. Gullett, Cassiana E. Bittencourt, Susan Benson, April M. Bobenchik, Robert L. Sautter, Vickie Baselski, Michel C. Atlas, Elizabeth M. Marlowe, Nancy S. Miller, Monika Fischer, Sandra S. Richter, Peter Gilligan, James W. Snyder
Clinical Microbiology Reviews May 2019, 32 (3) e00032-18; DOI: 10.1128/CMR.00032-18
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    • SUMMARY
    • INTRODUCTION
    • METHODS
    • RESULTS
    • ADDITIONAL CONSIDERATIONS
    • FUTURE RESEARCH
    • CONCLUSIONS
    • APPENDIX
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
    • Author Bios
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KEYWORDS

C. difficile infection
diagnostic accuracy
laboratory diagnosis
meta-analysis
systematic review

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