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Review

Convalescent Plasma Therapy for COVID-19: State of the Art

Daniele Focosi, Arthur O. Anderson, Julian W. Tang, Marco Tuccori
Daniele Focosi
aNorth-Western Tuscany Blood Bank, Pisa University Hospital, Pisa, Italy
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  • ORCID record for Daniele Focosi
Arthur O. Anderson
bDepartment of Respiratory Mucosal Immunity, US Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA
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Julian W. Tang
cRespiratory Sciences, University of Leicester, Leicester, United Kingdom
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Marco Tuccori
dDivision of Pharmacology and Pharmacovigilance, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
eUnit of Adverse Drug Reaction Monitoring, Pisa University Hospital, Pisa, Italy
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DOI: 10.1128/CMR.00072-20
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SUMMARY

Convalescent plasma (CP) therapy has been used since the early 1900s to treat emerging infectious diseases; its efficacy was later associated with the evidence that polyclonal neutralizing antibodies can reduce the duration of viremia. Recent large outbreaks of viral diseases for which effective antivirals or vaccines are still lacking has renewed the interest in CP as a life-saving treatment. The ongoing COVID-19 pandemic has led to the scaling up of CP therapy to unprecedented levels. Compared with historical usage, pathogen reduction technologies have now added an extra layer of safety to the use of CP, and new manufacturing approaches are being explored. This review summarizes historical settings of application, with a focus on betacoronaviruses, and surveys current approaches for donor selection and CP collection, pooling technologies, pathogen inactivation systems, and banking of CP. We additionally list the ongoing registered clinical trials for CP throughout the world and discuss the trial results published thus far.

  • Copyright © 2020 American Society for Microbiology.

All Rights Reserved.

This article is made available via the PMC Open Access Subset for unrestricted noncommercial re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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Convalescent Plasma Therapy for COVID-19: State of the Art
Daniele Focosi, Arthur O. Anderson, Julian W. Tang, Marco Tuccori
Clinical Microbiology Reviews Aug 2020, 33 (4) e00072-20; DOI: 10.1128/CMR.00072-20

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Convalescent Plasma Therapy for COVID-19: State of the Art
Daniele Focosi, Arthur O. Anderson, Julian W. Tang, Marco Tuccori
Clinical Microbiology Reviews Aug 2020, 33 (4) e00072-20; DOI: 10.1128/CMR.00072-20
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  • Article
    • SUMMARY
    • INTRODUCTION
    • CP DONOR RECRUITMENT STRATEGIES
    • CONVALESCENT PLASMA AND PATHOGEN INACTIVATION
    • CP BANKING
    • LESSONS FROM SARS
    • LESSONS FROM MERS
    • CONVALESCENT PLASMA FOR COVID-19
    • MONITORING RESPONSE TO CP TREATMENT
    • CONCERNS
    • SIDE BENEFITS FROM CP IN COVID-19
    • CONCLUSIONS
    • REFERENCES
    • Author Bios
  • Figures & Data
  • Info & Metrics
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KEYWORDS

Ebola virus disease
Middle East respiratory syndrome
antibody-dependent enhancement
convalescent blood product
convalescent plasma
convalescent whole blood
coronavirus disease 2019
enzyme-linked immunosorbent assay
intravenous immunoglobulins
plaque reduction neutralization test
SARS

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