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Review

Progress and Challenges in the Prevention, Diagnosis, and Management of Cytomegalovirus Infection in Transplantation

Ajit P. Limaye, Tara M. Babu, Michael Boeckh
Ajit P. Limaye
aDivision of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA
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Tara M. Babu
bDivision of Infectious Diseases, University of Rochester Medical Center, Rochester, New York, USA
cDepartment of Infectious Diseases, Overlake Medical Center, Bellevue, Washington, USA
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Michael Boeckh
aDivision of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA
dVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
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DOI: 10.1128/CMR.00043-19
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SUMMARY

Hosts with compromised or naive immune systems, such as individuals living with HIV/AIDS, transplant recipients, and fetuses, are at the highest risk for complications from cytomegalovirus (CMV) infection. Despite substantial progress in prevention, diagnostics, and treatment, CMV continues to negatively impact both solid-organ transplant (SOT) and hematologic cell transplant (HCT) recipients. In this article, we summarize important developments in the field over the past 10 years and highlight new approaches and remaining challenges to the optimal control of CMV infection and disease in transplant settings.

FOOTNOTES

    • Published 28 October 2020.
  • Supplemental material is available online only.

  • Copyright © 2020 American Society for Microbiology.

All Rights Reserved.

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Progress and Challenges in the Prevention, Diagnosis, and Management of Cytomegalovirus Infection in Transplantation
Ajit P. Limaye, Tara M. Babu, Michael Boeckh
Clinical Microbiology Reviews Oct 2020, 34 (1) e00043-19; DOI: 10.1128/CMR.00043-19

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Progress and Challenges in the Prevention, Diagnosis, and Management of Cytomegalovirus Infection in Transplantation
Ajit P. Limaye, Tara M. Babu, Michael Boeckh
Clinical Microbiology Reviews Oct 2020, 34 (1) e00043-19; DOI: 10.1128/CMR.00043-19
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  • Top
  • Article
    • SUMMARY
    • INTRODUCTION
    • DIAGNOSTICS
    • PREVENTION: STRATEGIES
    • PREVENTION: NOVEL AGENTS AND APPROACHES
    • DRUG-RESISTANT/REFRACTORY CMV: IDENTIFICATION OF RESISTANCE AND ALGORITHMS FOR TREATMENT
    • NEWER DRUGS AND APPROACHES FOR RESISTANT/REFRACTORY CMV
    • ONGOING AND RECENTLY COMPLETED TRIALS
    • CONCLUSIONS AND FUTURE DIRECTIONS
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
    • Author Bios
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

Cytomegalovirus
Antiviral Agents
clinical trials
diagnostics
immune monitoring
immunocompromised hosts
transplant infectious diseases
Transplantation
Vaccines

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