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Review

Understanding the Impact of Resistance to Influenza Antivirals

Edward C. Holmes, Aeron C. Hurt, Zuzana Dobbie, Barry Clinch, John S. Oxford, Pedro A. Piedra
Edward C. Holmes
aMarie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences, The University of Sydney, Sydney, Australia
bMarie Bashir Institute for Infectious Diseases and Biosecurity, School of Medical Sciences, The University of Sydney, Sydney, Australia
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Aeron C. Hurt
cF. Hoffmann-La Roche Ltd., Basel, Switzerland
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Zuzana Dobbie
cF. Hoffmann-La Roche Ltd., Basel, Switzerland
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Barry Clinch
dRoche Products Ltd., Welwyn Garden City, United Kingdom
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John S. Oxford
eBlizzard Institute, Queen Mary College, London, United Kingdom
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Pedro A. Piedra
fDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
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DOI: 10.1128/CMR.00224-20
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Article Information

DOI 
https://doi.org/10.1128/CMR.00224-20
PubMed 
33568554

Published By 
American Society for Microbiology Journals
History 
  • Published online February 10, 2021.

Copyright & Usage 
Copyright © 2021 American Society for Microbiology. All Rights Reserved.

Author Information

  1. Edward C. Holmesa,b,
  2. Aeron C. Hurtc,
  3. Zuzana Dobbiec,
  4. Barry Clinchd,
  5. John S. Oxforde and
  6. Pedro A. Piedraf
  1. aMarie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences, The University of Sydney, Sydney, Australia
  2. bMarie Bashir Institute for Infectious Diseases and Biosecurity, School of Medical Sciences, The University of Sydney, Sydney, Australia
  3. cF. Hoffmann-La Roche Ltd., Basel, Switzerland
  4. dRoche Products Ltd., Welwyn Garden City, United Kingdom
  5. eBlizzard Institute, Queen Mary College, London, United Kingdom
  6. fDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
  • Address correspondence to Edward C. Holmes, edward.holmes{at}sydney.edu.au.
  • Citation Holmes EC, Hurt AC, Dobbie Z, Clinch B, Oxford JS, Piedra PA. 2021. Understanding the impact of resistance to influenza antivirals. Clin Microbiol Rev 34:e00224-20. https://doi.org/10.1128/CMR.00224-20.

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Understanding the Impact of Resistance to Influenza Antivirals
Edward C. Holmes, Aeron C. Hurt, Zuzana Dobbie, Barry Clinch, John S. Oxford, Pedro A. Piedra
Clinical Microbiology Reviews Feb 2021, 34 (2) e00224-20; DOI: 10.1128/CMR.00224-20

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Understanding the Impact of Resistance to Influenza Antivirals
Edward C. Holmes, Aeron C. Hurt, Zuzana Dobbie, Barry Clinch, John S. Oxford, Pedro A. Piedra
Clinical Microbiology Reviews Feb 2021, 34 (2) e00224-20; DOI: 10.1128/CMR.00224-20
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  • Top
  • Article
    • SUMMARY
    • INTRODUCTION
    • THE EVOLUTION OF DRUG RESISTANCE
    • CLINICAL IMPACT OF ANTIVIRAL RESISTANCE
    • FITNESS AND TRANSMISSION OF RESISTANT VIRUSES
    • MONITORING RESISTANCE
    • CONCLUSIONS
    • ACKNOWLEDGMENTS
    • REFERENCES
    • Author Bios
  • Figures & Data
  • Info & Metrics
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KEYWORDS

Antiviral Agents
drug resistance evolution
influenza

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