TABLE 1

Invasive early-onset a neonatal sepsis cases and deaths, Active Bacterial Core Surveillance Program, 2005 to 2008 b

Yr or pathogenTotal Black preterm c Black term d Nonblack preterm c Nonblack term d
No. of cases (no. of cases/1,000 live births)No. of deaths (CFR [%]) e No. of cases (no. of cases/1,000 live births)No. of deaths (CFR [%])No. of cases (no. of cases/1,000 live births)No. of deaths (CFR [%])No. of cases (no. of cases/1,000 live births)No. of deaths (CFR [%])No. of cases (no. of cases/1,000 live births)No. of deaths (CFR [%])
Yr
    All658 (0.77)72 (10.9)131 (5.14)32 (24.4)120 (0.89)2 (1.7)158 (2.27)34 (21.5)249 (0.040)4 (1.6)
    2005 f 122 (0.77)10 (8.2)23 (4.25)5 (21.7)30 (1.07)1 (3.3)26 (2.00)4 (15.4)43 (0.38)0 (0)
    2006185 (0.79)20 (10.8)30 (4.45)10 (33.3)39 (1.11)1 (2.6)47 (2.41)8 (17.0)69 (0.40)1 (1.4)
    2007174 (0.75)16 (9.2)40 (6.01)7 (17.5)25 (0.69)0 (0)39 (2.11)8 (20.5)70 (0.41)1 (1.4)
    2008177 (0.76)26 (14.7)38 (5.71)10 (26.3)26 (0.72)0 (0)46 (2.48)14 (30.4)67 (0.39)2 (3.0)
Pathogens
    GBS249 (0.29)17 (6.8)40 (1.57)9 (22.5)75 (0.55)0 (0)38 (0.55)8 (21.1)96 (0.15)0 (0)
    Escherichia coli 159 (0.19)39 (24.5)46 (1.81)17 (37.0)16 (0.12)1 (6.3)66 (0.95)19 (28.8)31 (0.05)2 (6.5)
    Ampr E. coli g 81 (0.09)16 (19.8)31 (1.22)9 (29.0)3 (0.02)0 (0)31 (0.45)6 (19.4)16 (0.03)1 (6.3)
    Viridans group streptococci118 (0.14)3 (2.5)16 (0.63)2 (12.5)16 (0.12)0 (0)18 (0.26)0 (0)68 (0.11)1 (1.5)
    Staphylococcus aureus 26 (0.03)2 (7.7)2 (0.08)1 (50.0)5 (0.04)1 (20.0)1 (0.01)0 (0)18 (0.03)0 (0)
    Haemophilus influenzae 26 (0.03)4 (15.4)10 (0.39)1 (10.0)0 (0)0 (0)12 (0.17)3 (25.0)4 (0.006)0 (0)
    Other h 80 (0.09)7 (8.8)17 (0.67)2 (11.8)8 (0.06)0 (0)23 (0.33)4 (17.4)32 (0.05)1 (3.1)
  • a Occurring in infants aged 0 to 2 days (0 to 72 h of life).

  • b Adapted from reference 12 with permission of the publisher.

  • c Preterm is classified as infants born at <37 weeks of gestation.

  • d Term infants are born at ≥37 weeks of gestation.

  • e CFR, case fatality ratio.

  • f Includes cases from Connecticut and selected counties in California and Georgia; statewide surveillance in Minnesota began in 2006.

  • g Ampr, ampicillin resistant. Antimicrobial susceptibility data was available for 121 (76%) of 159 E. coli cases; those with missing susceptibility information were excluded from incidence and case fatality ratio calculations for ampicillin-resistant E. coli.

  • h Other (n = 80) includes Enterococcus (n = 14), Listeria monocytogenes (n = 9), Streptococcus pneumoniae (n = 8), Citrobacter koseri (n = 7), group D streptococcus (n = 7), Klebsiella pneumoniae (n = 6), group A streptococcus (n = 3), Streptococcus bovis (n = 3), Streptococcus not otherwise identified to the species level (n = 3), Bacteroides fragilis (n = 2), group G streptococcus (n = 2), Peptostreptococcus (n = 2), Streptococcus not group D (n = 2), and 1 each for the following pathogens: Aerococcus viridans, Actinomyces, Clostridium septicum, Enterobacter aerogenes, Kingella denitrificans, Klebsiella ornithinolytica, Moraxella species, Pseudomonas aeruginosa, Pseudomonas oryzihabitans, Pseudomonas stutzeri, Serratia marcescens, and Shigella species.