TABLE 5

Relationship between Lewis and Secretor genotypes and phenotypes

Lewis phenotypeGeneaSecretor typebSecreted antigenc
FUT2FUT3LeaLebABO
Lewis positive
    Le(a+b−)0+N+00
    Le(a−b+)++Y+++
    Le(a+b+w)d + (Sew )+Y+
Lewis null
    Le(a−b−)+0Y00+
    Le(a−b−)00N000
  • a Inheritance of at least one functional glycosyltransferase gene.

  • b Ability to secrete ABH antigens in saliva and other secretions. N, nonsecretor; Y, secretor.

  • c Presence of Lewis and type 1 ABH antigens in saliva and other secretions.

  • d Very weak Leb expression due to inheritance of an SeW FUT2 allele. Le(a+b+) may reflect either the SeW /SeW or SeW /se genotype. SeW /se can also be typed as Lewis null.