TABLE 10

Effect of O-linked glycans on P. falciparum RBC invasion

Antigen(s)O-linked glycan structureSusceptibility to P. falciparumaDescription
M/NEBA-175 receptorSensitive>70% O-glycan on GYPA, GYPB
NeuAcα2→3Galβ1→3GalNAc-O-Ser/Thr Epitope anti-Pr
↑6
NeuAcα2
Can, Tm, M1, SjNeuAcα1→3Galβ1-3GalNAc-O-Ser/ThrUnknownBlacks > whites
↑6
(±Fuc-)Galβ1-3/4GlcNAcβ1
CadGalNAcβ1-4ResistantRare, GM2 active
〉 Galβ1→3GalNAc-O-Ser/Thr
NeuAcα2-3 ↑6
NeuAcα2
TGalβ1→3GalNAc-O-Ser/ThrResistantNeuraminidase
TnGalNAc-O-Ser/ThrResistantRare
  • a Sensitivity of red cells to P. falciparum infection in vitro.