TABLE 3

Clinical and demographic characteristics of large cohorts of patients with S. aureus infective endocarditisi

CharacteristicValue reported in reference:
125170146173171172
No. of patients558260133746127
RegionMultinationalDenmarkSpainFinlandFranceAustralia
Study typeMulticenterMulticenterSingle centerMulticenterSingle centerSingle center
Period (yr)2000–20031982–19911985–20061999–20021990–20001991–2006
Age (yr)57a 68a NA55b 57b 64a
No. (%) of patients
    Males341 (61)145 (56)89 (77)47 (64)42 (69)18 (67)
    With acquisition type
        HCA218 (39)88c (33)29c (22)34c (46)NA26 (96)
Community326 (58)172 (67)104 (78)40 (54)NA1 (4)
    IDU117 (21)0d (0)62 (47)20 (27)NA1 (4)
    On dialysis79 (14)NANA6 (8)7 (11)1 (4)
    With diabetes110 (20)35 (13)2 (6)19 (26)12 (20)8 (30)
    With intravascular device159 (28)23 (9)NA10 (14)11 (17)14 (52)
    With native valve401 (72)215 (83)113 (85)57 (77)55 (90)17 (63)
    With prosthetic valve86 (15)24 (9)20 (15)17 (23)6 (10)10 (37)
    With location of vegetations
        Aortic143 (29)84 (32)21 (16)26 (35)22 (36)6 (22)
        Mitral224 (46)100 (38)42 (32)22 (30)28 (46)15 (56)
        Tricuspid/pulmonary132 (27)13 (5)58 (47)16 (22)11 (18)2 (7)
    With MRSA283/424 (67)0 (0)8 (6)0e (0)NA27f (100)
    With complication
        Stroke119 (21)91 (35)30 (23)13 (18)21 (34)9 (35)
        Cardiac failure161 (29)139 (53)36 (27)NA19 (31)4 (15)
        Intracardiac abscess71 (13)NA12 (9)3 (4)14 (23)3 (12)
    With in-hospital mortality125 (22)164g (63)37 (28)17h (23)21 (34)15 (66)
    With surgery211 (38)27 (10)39 (29)7 (9)20 (33)16 (59)
  • a Median age.

  • b Mean age.

  • c For several studies, only nosocomial versus community-onset data were collected.

  • d IDUs were excluded from the study.

  • e MRSA was excluded from the study.

  • f Only MRSA was reported in this study.

  • g This study included 83 patients not clinically known to have S. aureus IE but who were subsequently diagnosed at autopsy.

  • h This study referred to 28-day mortality.

  • i HCA, health care associated; IDU, intravenous drug user; MRSA, methicillin-resistant S. aureus; NA, not available.