TABLE 2

Model inputs and baseline estimates for probabilities, lengths of stay, and costs

InputMean base-case value (range)Type of distribution (range or mean [SD])Reference(s)
Mortality probabilities
    mRDT0.11 (0.08–0.14)Uniform (0.08–0.14)9, 1725, 34, 3645
    Conventional laboratory methods0.16 (0.12–0.19)Uniform (0.12–0.19)9, 1725, 34, 3645
    mRDT with ASP (A)0.11 (0.08–0.15)Uniform (0.08–0.15)9, 1723, 25, 34, 36, 37, 3942, 44, 45
    mRDT without ASP (B)0.10 (0.07–0.14)Uniform (0.07–0.14)24, 38, 43
    Conventional laboratory methods with ASP (C)0.16 (0.12–0.20)Uniform (0.12–0.20)9, 1723, 25, 34, 36, 37, 3942, 44, 45
    Conventional laboratory methods without ASP (D)0.15 (0.11–0.19)Uniform (0.11–0.19)24, 38, 43
    PCR with ASP (A1)0.12 (0.05–0.22)Uniform (0.05–0.22)9, 18, 25, 44
    MALDI-TOF analysis with ASP (A2)0.08 (0.04–0.12)Uniform (0.04–0.12)17, 23, 37, 39
    PNA-FISH with ASP (A3)0.15 (0.03–0.33)Uniform (0.03–0.33)20-22, 36
    BC-GP with ASP (A4)0.16 (0.04–0.33)Uniform (0.04–0.33)19, 40, 45
    BC-GN with ASP (A5)0.08 (0.04–0.12)Uniform (0.04–0.12)34, 41, 42
    PCR without ASP (B1)0.12 (0.07–0.18)Uniform (0.07–0.18)38, 43
    PNA-FISH without ASP (B2)0.08 (0.03–0.15)Uniform (0.03–0.15)24
Length of stay (days)
    mRDT11.58 (9.44–13.72)Gamma (11.58 [0.71])1719, 22, 23, 34, 37, 38, 40, 55
    Conventional laboratory methods14.02 (11.23–16.80)Gamma (14.02 [0.93])1719, 22, 23, 34, 37, 38, 40, 55
    mRDT with ASP (A)9.89 (8.04–11.74)Gamma (9.89 [0.62])1719, 22, 23, 34, 37, 40
    mRDT without ASP (B)18.37 (13.79–22.97)Gamma (18.37 [1.53])38, 55
    Conventional laboratory methods with ASP (C)13.31 (10.42–16.19)Gamma (13.31 [0.96])1719, 22, 23, 34, 37, 40
    Conventional laboratory methods without ASP (D)17.98 (8.99–35.96)Gamma (17.89 [4.50])38, 55
    PCR with ASP (A1)15.30 (12.25–18.35)Gamma (15.30 [1.02])18
    MALDI-TOF analysis with ASP (A2)8.97 (5.84–12.09)Gamma (8.97 [1.04])23, 28, 37
    PNA-FISH with ASP (A3)17.00 (9.86–24.14)Gamma (17.00 [2.38])22
    BC-GP with ASP (A4)7.82 (6.90–8.75)Gamma (7.82 [0.31])19, 40
    BC-GN with ASP (A5)10.67 (7.46–13.88)Gamma (10.67 [1.07])34
    PCR without ASP (B)15.20 (8.83–21.57)Gamma (15.20 [2.12])38
    PNA-FISH without ASP (B2)18.70 (15.47–21.93)Gamma (18.70 [1.0])55
Costs (US$)
    Blood culture178.05 (89.03–356.10)Gamma (178.05 [44.51])65
    PCR67.90 (33.95–135.80)Gamma (67.90 [16.98])68
    BC-GP99.61 (49.81–199.22)Gamma (99.61 [24.90])69
    BC-GN105.89 (52.95–211.78)Gamma (105.89 [26.47])42
    PNA-FISH139.05 (69.53–278.10)Gamma (139.05 [34.76])70
    MALDI-TOF analysis45.99 (23.00–91.98)Gamma (45.99 [11.50])71
    Conventional laboratory methods5.09 (2.55–10.18)Gamma (5.09 [1.27])30
    mRDT91.69 (45.85–183.38)Gamma (91.69 [22.92])42, 6871
    ASP per patient179.29 (89.65–358.58)Gamma (179.29 [44.82])31
    In-patient hospitalization per day for Rhode Island, 20153,080.80 (1,540.40–6,161.60)Gamma (3,080.80 [770.20])32