MBL polymorphisms and infections with Mycobacterium tuberculosis

Study descriptionReference
MBL mutations compared in 277 patients with pulmonary tuberculosis (TB) and 288 household contacts; HYA/HYA subjects
    were protected against tuberculosis (OR, 0.09; P < 1 × 10−6); LYB/LYD subjects were susceptible to disease (OR, 49;
    P < 1 × 10−6)52
Relationships between the susceptibility to TB exon 1 mutations and MBL levels in Turkish children; 27 children with
    pulmonary TB and 17 with extrapulmonary TB compared to 99 age-matched healthy controls; AB genotype (low MBL
    level) significantly lower in patients (9.1%) than in controls (27.3%) (P < 0.011); Median MBL levels significantly lower in
    the control group than in cases73
Study of MBL levels and MBL2 gene polymorphisms in HIV-1-infected patients without TB (HIV+ TB) (n = 151) and with
    TB (HIV+ TB+) (n = 109), HIV TB+ patients (n = 148), and healthy controls (n = 146); MBL levels significantly higher
    among HIV TB+ and HIV+ TB+ patients than controls and HIV+ TB patients (P < 0.05); increased frequency of O/O
    genotype and YY genotype among HIV TB+ patients than controls; HIV+ TB+ patients had significantly increased
    frequency of YA/YA diplotype (high MBL levels) compared to controls (P = 0.03); HIV+ TB+ patients had significantly
    decreased frequency of medium MBL expression diplotypes (XA/XA and YA/YO) compared to HIV+ TB patients and
    healthy controls; YA/YA diplotype (high MBL) may predispose HIV+ patients to TB, while O/O genotype (low MBL) may
    predispose to TB in HIV individuals; medium MBL expression diplotypes may protect against TB in HIV patients2
Six MBL SNPs (A/B, A/C, A/D, H/L, Y/X, and P/Q) studied in 152 Chinese males with pulmonary TB vs 293 healthy
    controls; none of the variants individually contributed to risk of TB, although there was a slightly increased risk with XB
    (low MBL) haplotype258
MBL-2 structural and promoter polymorphisms in HIV infection and TB in a white Spanish population; 615 HIV+ with and
    without TB, 127 HIV TB+ patients, 142 TB household contacts, and 344 controls; frequency of low producer or
    nonproducer mbl-2 genotypes lower in HIV patients than controls; HIV TB+ patients had lower frequencies of low
    producer or nonproducer alleles and genotypes than HIV+ TB patients and controls; positive correlation between
    incidence of TB and frequency of nonproducer mbl-2 alleles in Western Europe; MBL deficiency associated with lower risk
    of TB in HIV patients148
MBL B allele frequency lower in controls than TB cases among African-Americans (P < 0.01) but no differences found
    between cases and controls of white and Hispanic ethnicity112
Study of MBL alleles in 109 TB+ (and HIV-uninfected) patients living in Denmark and 250 white control subjects; low-
    expressing MBL genotype more frequent in controls than in white patients; similar trend in patients of other ethnic origin;
    heterozygosity for MBL variant alleles (low serum MBL) associated with protection against TB413
No significant difference in frequency of MBL variant alleles in Turkish population with or without TB334
Study of role of MBL in HIV and TB in Tanzania; HIV+ TB+ patients (n = 150) vs HIV TB+ patients (n = 94) vs HIV
    TB controls (n = 113); HIV TB+ patients had significantly higher MBL levels than controls, HIV+ TB+, and HIV+
    TB patients; low MBL associated with HIV risk; high MBL associated with TB risk154
MBL alleles and TB in South African population; MBL B allele found in 22 of 79 (28%) of TB-negative controls compared
    with 12 of 91 (13%) of patients with pulmonary TB (P < 0.017) and 5 of 64 (8%) of patients with TB meningitis
    (P < 0.002); significantly lower serum MBL in TB-negative controls than in successfully treated
    TB patients (P < 0.004)190
Correlation between B and C alleles (prevalence in sub-Saharan Africans, 29%) and TB infection; areas with high prevalence
    of variant alleles (low MBL) have higher incidence of TB; high incidence of TB may select for low-MBL-expressing alleles305
No correlation between variant MBL alleles and TB in West African population25