TABLE 5.

Clinically identified inhibitor-resistant SHV β-lactamasesa

β-LactamaseAmino acid at positionb:
3569130140146187192193234238240
SHV-1LeuMetSerAlaAlaAlaLysLeuLysGlyGlu
SHV-10GlyArgAsnValSerLys
SHV-26Thr
SHV-49Ile
SHV-56GlnArg
SHV-72ValArg