TABLE 6.

Clinically identified complex mutants of TEM (CMT) β-lactamasesa

β-LactamaseAmino acid at positionb:
3969104130164237238240244265275276284
TEM-1GlnMetGluSerArgAlaGlyGluArgThrArgAsnAla
TEM-50 (CMT-1)LeuLysSerAsp
TEM-68SerLysMetLeu
TEM-89 (CMT-3)LysLysGlySer
TEM-109 (CMT-5)LeuLysHisCys
TEM-121 (CMT-4)LysLysSerThrLysSer
TEM-151ValHisAspGly
TEM-152ValHisLysAsp
TEM-154LeuSer
TEM-158 (CMT-9)LeuSerAsp