TABLE 1.

Classes and representative antimalarial drugsa

Type of drugTargetClinical applicationProphylaxisLicensed drug(s)Experimental drug(s)
Blood schizontocideTrophozoite in bloodTreatment of acute malariaSuppressiveChloroquine, quinine, mefloquine, doxycycline, AV-PG, DH-PPTafenoquine, ACTs
Primary tissue schizontocideActive schizont in liverNoneCausalPrimaquineTafenoquine
HypnozoitocideDormant hypnozoite in liverPrevention of relapseNonePrimaquineTafenoquine, elubaquine
GametocytocideGametocyte in bloodPrevention of transmissionNonePrimaquineTafenoquine, artesunate, artemether
SporontocideForms in mosquito including sporozoitePrevention of transmissionCausal prophylaxisPrimaquineTafenoquine
  • a AV-PG, atovaquone-proguanil (Malarone); DH-PP, dihydroartemisinin-piperaquine (Artekin); ACTs, artemisinin combined therapies (many in evaluation).